Enzalutamide Shows Survival Benefit in Metastatic Prostate Cancer

urine test tubeThe androgen-receptor inhibitor enzalutamide already has established benefit in castration-resistant prostate cancer. Now the randomized phase III trial ENZAMET is exploring the impact of adding enzalutamide to testosterone suppression for metastatic hormone-sensitive prostate cancer (mHSPC). Interim analysis showed significantly prolonged overall survival with less cancer progression.
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Radiation No Longer Indicated for Most Retroperitoneal Sarcomas

PET scan image of Retroperitoneal SarcomaA study presented at the 2019 ASCO Annual Meeting showed that radiation therapy prior to surgery does not reduce the rate of local recurrence among most patients with retroperitoneal sarcoma (RPS). Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) was the only U.S. center to participate in the European trial of 256 patients.
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Link Found Between Immune Activation and Recurrence of HER2+ Breast Cancer

A scientist looking at a DNA sequence as part of the HER2 studyDana-Farber Cancer Institute physician-researcher Ian E. Krop, MD, PhD, has uncovered a promising way to identify patients who will respond well to certain adjuvant therapies for treating HER2+ breast cancer. He presented the findings of his biomarker analysis at the 2019 ASCO Annual Meeting.

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Improving Survival Benefit in Glioblastoma Patients with Neoadjuvant Immunotherapy

MR images of a brain at baseline vs. ONC201, a  Neoadjuvant ImmunotherapyA new study featured on the cover of the March issue of Nature Medicine offers hope for treating patients with glioblastoma. In a small randomized controlled clinical trial, patients with recurrent glioblastoma lived nearly twice as long if they received an immunotherapy drug prior to and following surgery, compared to patients who only received the drug after surgery.
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MR-Guided Radiation Therapy: A More Precise Way to See, Track and Treat Tumors

New MR-Imaging (Left) – Traditional Cone-beam CT (Right)
New MR-Imaging (Left) – Traditional Cone-beam CT (Right)

For the first time, cancer patients in New England will have a cutting-edge option for radiation treatment of soft-tissue tumors. The new MR-Guided Radiation Therapy (MR-RT) treatment at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), launching this summer, will give physicians real-time, pinpoint accuracy for radiation planning and treatment.
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New Hope for Late-Stage Endometrial Cancer Patients

drawing of DNA double helix with the phrase Novel therapies in Endometrial CancerWhen diagnosed and treated in its early stages, endometrial cancer is largely curable. However, for the 10 to 15 percent of patients diagnosed with late-stage disease, standard therapy does not lead to a cure.
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Leading the Country in the Care of Patients with Hereditary GI Cancers

Blood samples in laboratory (coagulation test)Over the past two decades, the Dana-Farber/Brigham and Women’s Cancer Center  (DF/BWCC) has become a national leader in the care of patients with hereditary gastrointestinal cancers, from Lynch syndrome to polyposis syndromes.
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Neurotoxicity Associated With CAR T Cell Therapy

drawing of a Chimirc Antigen ReceptorChimeric antigen receptor T (CAR T) cell therapy has become an important tool in the treatment of relapsed and refractory malignancy. However, it is associated with significant and unique neurological toxicities.

A multidisciplinary team of clinicians at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) are among the first in the nation to study this issue as a team prospectively; their findings are about to be published in the journal Brain.
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New Center Addresses Research and Treatment Challenges in Young-Onset Colorectal Cancer

colorectal cancer cells stained under a microscopeColorectal cancer remains a major health problem in the United States. It’s the third most common type of cancer and the second leading cause of cancer death.

While the incidence of colorectal cancer is decreasing somewhat in the population, it has increased by 51 percent in people under the age of 50. This trend is expected to continue, with an estimated 90 percent increase in colon cancer incidence and 124 percent increase in rectal cancer incidence by 2030.
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Expanding the Frontiers of Breast Cancer Immunotherapy

Pipette dropping stem cell research fluid on pcr plate. Medical Dropper

Elizabeth A. Mittendorf, MD, PhD, a breast cancer surgeon and international leader in breast cancer vaccines, recently joined Brigham and Women’s Hospital (BWH) from the MD Anderson Cancer Center in Houston, where her research focused on vaccines that target the HER2 protein expressed on many breast tumors. At the Brigham, her work focuses on advancing our understanding of breast cancer immunotherapies.

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