Increasing Clinical Trial Diversity With Federal Incentives and Regulations

Doctor In Blue Medical Gloves Taking Dose Of Vaccine From Vial With Syringe

Recent U.S. legislation requires clinical trial sponsors to submit a diversity action plan for pivotal studies of new drugs. Still, Thomas J. Hwang, MD, and a colleague propose a combination of federal incentives and regulations to advance clinical trial equity and resolve gaps in participant representation.


Brigham Urologists Present at AUA 2023

Audience listens to the speech of the lecturer in the conference hall

Leaders from the Division of Urology at Brigham and Women’s Hospital will present their latest research to international urologists at the American Urological Association’s (AUA) 2023 Annual Meeting, held April 28 – May 1 in Chicago, IL.


Feasibility Study: Multi-Section Robotic Ureteroscope Outperforms Flexible Scope

Anatomy structure of human kidneys

Researchers at Brigham and Women’s Hospital modified a robotic-assisted cardiac catheter ablation device to treat kidney stones and compared it with a standard flexible ureteroscope. They found the robotic device was more maneuverable and facilitated precision aim at targets in each renal calyx.


BPH Histopathologic Subtypes Do Not Influence Outcomes of TURP

Illustration showing healthy prostate and benign prostatic hyperplasia

In the first study of its kind, Brigham and Women’s Hospital researchers investigated whether the stromal‐predominant benign prostatic hyperplasia (BPH) subtype negatively affects outcomes of transurethral resection of the prostate, as reactive stromal myofibroblasts support a progressive inflammatory response.


Delay in Salvage Therapy Increases Risk of Death for Some Prostate Cancer Patients

Study led by Anthony Victor D'Amico, MD, PhD, chief of Genitourinary Radiation Oncology, Dana-Farber Brigham Cancer Center.

A recently approved and widely adopted imaging study that improves detection of prostate cancer recurrence in patients who have undergone radical prostatectomy is having an unintended effect of delaying potentially life-saving salvage treatment with radiation and androgen deprivation therapy, according to a study led by Anthony Victor D’Amico, MD, PhD, chief of Genitourinary Radiation Oncology, Dana-Farber Brigham Cancer Center.

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Benefits of Electronic Health Records in the Management of Hypogonadal Men

Doctor working on laptop computer and medical stethoscope on clipboard on desk, EHR concept

Electronic health records (EHRs) have multiple benefits for both clinicians and patients, but can lead to clinician burnout. Martin Kathrins, MD, and Anna Goldman, MD, of Brigham and Women’s Hospital, discuss how EHRs can optimize the treatment of hypogonadal men.


5-item Frailty Index Predicts Complications of Endoscopic Treatment for Benign Prostatic Obstruction

Urologist pointing to anatomical model of male reproductive system

The 5-item Frailty Index (5i-FI) accurately predicts morbidity and mortality after radical prostatectomy, cystectomy, and partial nephrectomy. Now, Brigham researchers report the 5i-FI is also useful for predicting surgical complications after endoscopic treatment for benign prostatic obstruction.


Pilot Study: Analyzing Urologists’ Efficiency During Ureteroscopy

Closeup Image of Flexible Ureteroscope Device in Container

Flexible ureteroscopy (URS) is the most commonly used surgical procedure to treat nephrolithiasis, and Brigham researchers have begun to evaluate how surgeon movements affect URS efficiency. They report results from a pilot study that should inform improvement in endoscopist training and evaluation.


Reducing Healthcare Disparities: Q&A With Quoc-Dien Trinh, MD, MBA

Female doctor showing tablet to black male patient in hospital bed

As part of the United Against Racism initiative, Mass General Brigham implemented outreach programs across the system to reduce healthcare disparities. Quoc-Dien Trinh, MD, MBA, discusses the program he co-founded and the research his team is doing to improve care for people of color at Brigham and Women’s Hospital.


Biodegradable Implantable Device Developed for Intravesical Therapy of Bladder Disorders

3D rendering of human bladder anatomy highlighted orange

Implantable devices for drug delivery to the bladder require surgical implantation and removal. Scientists at Brigham and Women’s Hospital have invented a biodegradable ring-shaped implantable device (BRID) for long-term and local drug delivery inside the bladder that does not require a retrieval procedure.