Translating Discoveries Into Better Treatments for Inflammatory Bowel Disease

Profile photo of Scott B. Snapper, MD, PhD

Developing better treatments for IBD requires understanding the underlying biological causes driving different forms of the disease. The Brigham’s Scott B. Snapper, MD, PhD, has devoted his research to this topic, which currently ranges from the creation of better mouse models to fostering early-stage clinical trials.

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Novel Metrics for GERD Evaluation Have Prognostic Value in Idiopathic Pulmonary Fibrosis

Older woman holding chest, GERD symptoms/discomfort

Previous studies of GERD have relied on multichannel intraluminal impedance and pH testing, which has substantial limitations including the need to count reflux episodes. Now, researchers at Brigham and Women’s Hospital have linked more advanced impedance metrics to the prognosis of patients with IPF.

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Long-term Infliximab Does Not Contribute to Weight Gain in Patients With IBD

3D rendering of Tumor Necrosis Factor (TNF)-α Inhibitor molecule

Rachel W. Winter, MD, MPH, at Brigham and Women’s Hospital, and colleagues in Denmark conducted the largest study ever to evaluate weight change during TNF inhibitor therapy for patients with inflammatory bowel disease and report low weight gain overall with infliximab.

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Adjustable Intragastric Balloon Permits Individualized Weight Loss Therapy

3D rendering concept of a gastric balloon inside a stomach

In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.

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Researchers Probe Links Between Colorectal Cancer, Bariatric Surgery and the Microbiota

Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.

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Endoscopic Ultrasound–guided Gastroenterostomy Is a Viable Option for Palliation of Gastric Outlet Obstruction

Medical professional holding instrument for endoscopy with purple gloves

Ali Abbas, MD, MPH, Christopher C. Thompson, MD, MSc, and colleagues report similar technical success rates for endoscopic ultrasound–guided gastroenterostomy (EUS-GE) and surgical gastrojejunostomy, despite more advanced cancer stage and worse performance status in the EUS-GE cohort.

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Novel Treatment May Improve Transplant Outcomes in Patients With Obesity

Bariatric surgery in operating room with surgeon looking at monitor

In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.

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Working Outside of the Operating Room to Advance Surgical Care

Headshot of Douglas S. Smink, MD, MPH

Having dedicated his career to patient care, education and research, Douglas S. Smink, MD, MPH, embodies the classic tripartite mission of an academic medical center. He discusses his experience leading the Association of Program Directors in Surgery as well as his research on innovative gastrointestinal training.

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Oral Drug Developed at the Brigham Replicates Metabolic Benefits of Gastric Bypass

3d Rendering of gastric bypass on red background

Since many patients with diabetes are ineligible for RYGB or decline it, researchers at Brigham and Women’s Hospital developed an orally administered gut barrier coating for improving glucose homeostasis.

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