Nuclear Function Identified for an Oncogenic MicroRNA
Brigham researchers found that miR-10b seems to regulate mRNA splicing, suggesting an exciting new approach to research not just in glioma but in cancer more generally.
Read More...Category: Cancer
Specialty: Oncology
Making Headway in Targeting Glioblastoma Multiforme
Break Through Cancer is a foundation that brings together elite cancer research centers to collaborate on and accelerate research, clinical trials and cures for deadly cancers, including glioblastoma multiforme. The Brigham’s Nathalie Y. R. Agar, PhD, and E. Antonio Chiocca, MD, PhD, discuss this ambitious undertaking.
Read More...Researchers Probe Links Between Colorectal Cancer, Bariatric Surgery and the Microbiota
Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.
Read More...Role of DNA Damage Response Genes in Prostate Cancer Similar for African Americans, European Americans
Adam S. Kibel, MD, and Anna Plym, PhD, of the Division of Urology, and colleagues conducted the most comprehensive study to date on the role of inherited DNA damage response (DDR) genes in aggressive prostate cancer. They report high carrier frequency of DDR gene alterations in lethal cases irrespective of ancestry.
Read More...Endoscopic Ultrasound–guided Gastroenterostomy Is a Viable Option for Palliation of Gastric Outlet Obstruction
Ali Abbas, MD, MPH, Christopher C. Thompson, MD, MSc, and colleagues report similar technical success rates for endoscopic ultrasound–guided gastroenterostomy (EUS-GE) and surgical gastrojejunostomy, despite more advanced cancer stage and worse performance status in the EUS-GE cohort.
Read More...Esophagectomy Complication Rate Higher with Low-volume Surgeons Even at the Same High-volume Center
A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.
Read More...Survival Similar Whether Patients With Spinal Metastases Have Surgery or Not
Researchers at Brigham and Women’s Hospital examined the two-year natural history of spinal metastases in cancer patients treated operatively or non-operatively and found that both types of treatment yielded improvements in health-related quality of life, but there was no survival advantage with surgery.
Read More...Exploring the Role of Neurons in the Tumor Microenvironment that Drive Cancer Growth
Humsa Venkatesh, PhD, a cancer biologist, is studying the neural regulation of cancer and how nervous system cells found within the tumor microenvironment drive tumor growth. Her research has implications for primary brain tumors such as gliomas and for tumors that metastasize to the brain from other parts of the body.
Read More...Metabolic Syndrome and Its Treatment Affects Response to Androgen Deprivation Therapy in Metastatic Prostate Cancer
Adam S. Kibel, MD, and Jiun-Hung Geng, of the Brigham’s Division of Urology, and colleagues recently conducted the first study of how the combination of metabolic syndrome and its treatment affect response to androgen deprivation therapy in castration-sensitive prostate cancer.
Read More...Lower Steroid Dose for Initial Management of Hepatitis Secondary to Immune Checkpoint Inhibitors
Researchers at Brigham and Women’s Hospital conducted the first study to compare the outcomes of different steroid dosing regimens prescribed for patients with high-grade ICI hepatitis. Stephen D. Zucker, MD, Shilpa Grover, MD, MPH, Michael Li, MD, MPH, and colleagues present evidence for starting with the lower dose.
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