New Treatment Strategy Proposed for Rheumatic Heart Valve Disease

Close up of valve replacement surgery where artificial valve is being implanted

Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.


Timing of High-grade PVCs During Stress Testing Stratifies Risk of Cardiovascular Mortality

Electrocardiogram revealing premature ventricular contractions

Brigham and Women’s Hospital researchers investigated the prognostic value of premature ventricular contractions (PVCs) in asymptomatic individuals not suspected of having heart disease. High-grade PVCs that occurred during recovery from stress testing were associated with long-term cardiovascular mortality.


Esophagectomy Complication Rate Higher with Low-volume Surgeons Even at the Same High-volume Center

Close up of two surgeons beginning thoracic surgery

A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.


Exenatide Mini-Pump Demonstrates Cardiovascular Safety in Type 2 Diabetes

3D rendering of exenatide drug molecule

The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.


Study Explains Why Patients With Diabetes Are Prone to Thrombosis, Suggests New Therapeutic Target

Man puts on compression socks for thrombosis

An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.


“Enhanced Recovery After Surgery” Pathway Promising for Cardiac Surgery

Male patient lying in hospital bed recovering from surgery

In 2018, a multidisciplinary team at Brigham and Women’s Hospital developed a multimodal enhanced recovery after surgery (ERAS) program to optimize perioperative care in cardiac surgery. They report promising early results in Seminars in Thoracic and Cardiovascular Surgery.


Fundamental Differences Detected Between National Databases in Outcomes of OAAA Repair

Close up of abdominal surgery

Wide variability has been reported in the administrative and quality improvement databases that are used to guide evidence-based decision-making in vascular surgery. A Brigham team detected numerous differences in patient populations and outcomes between three national data repositories using OAAA repair as a model.


Frailty Status Predicts Mortality After In-hospital CPR

Hands of senior woman resting on cane handle

Ariela Orkaby MD, MPH, of the Brigham’s Division of Aging, and colleagues report that increased frailty status as rated on the Clinical Frailty Scale is associated with increased mortality in older adults after in-hospital cardiopulmonary resuscitation.


No Increased Risk of VTE With Tofacitinib vs. TNF Inhibitors in Routine Care

3D Rendering of Tofacitinib Drug Molecule

The Brigham’s Seoyoung C. Kim, MD, ScD, Michael E. Weinblatt, MD, Rishi J. Desai, PhD, and colleagues have analyzed new data that shows no increased risk of venous thromboembolism (VTE) in patients with rheumatoid arthritis who use tofacitinib.


Patients Receiving Implanted Devices Need Better Education About Device Documentation, Tracking

X-ray of a permanent pacemaker implant in the chest

A Brigham and Women’s Hospital team reports most patients were unaware of the availability of unique device identifiers for documentation and tracking of their device, and they mistrust having it shared outside the health care system.