Latest Clinical & Research News
Specialty: Heart & Vascular
Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.
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Brigham and Women’s Hospital researchers investigated the prognostic value of premature ventricular contractions (PVCs) in asymptomatic individuals not suspected of having heart disease. High-grade PVCs that occurred during recovery from stress testing were associated with long-term cardiovascular mortality.
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A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.
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The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.
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An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.
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In 2018, a multidisciplinary team at Brigham and Women’s Hospital developed a multimodal enhanced recovery after surgery (ERAS) program to optimize perioperative care in cardiac surgery. They report promising early results in Seminars in Thoracic and Cardiovascular Surgery.
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Wide variability has been reported in the administrative and quality improvement databases that are used to guide evidence-based decision-making in vascular surgery. A Brigham team detected numerous differences in patient populations and outcomes between three national data repositories using OAAA repair as a model.
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Ariela Orkaby MD, MPH, of the Brigham’s Division of Aging, and colleagues report that increased frailty status as rated on the Clinical Frailty Scale is associated with increased mortality in older adults after in-hospital cardiopulmonary resuscitation.
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The Brigham’s Seoyoung C. Kim, MD, ScD, Michael E. Weinblatt, MD, Rishi J. Desai, PhD, and colleagues have analyzed new data that shows no increased risk of venous thromboembolism (VTE) in patients with rheumatoid arthritis who use tofacitinib.
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A Brigham and Women’s Hospital team reports most patients were unaware of the availability of unique device identifiers for documentation and tracking of their device, and they mistrust having it shared outside the health care system.
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