Extended Use of Apixaban Tied to Reduced Risk of Hospitalization for Recurrent VTE

3D structure of apixaban on white background

Researchers at Brigham and Women’s Hospital recently published a nationwide U.S. study of patients who received more than 90 days of oral anticoagulation after hospitalization for VTE. They found dispensing of apixaban, versus warfarin, was associated with a modestly lower hospitalization rate for recurrent VTE.

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Brigham Awarded First Three-Star STS Rating for Coronary Artery Bypass Grafting Procedures

Medical team works in modern operating room performing cardiac surgery

The Division of Cardiac Surgery earned a distinguished three-star rating from The Society of Thoracic Surgeons (STS) for patient care and outcomes in isolated coronary artery bypass grafting procedures. George Tolis, MD, section chief of Coronary Surgery and General Cardiac Surgery, explains the rating and its meaning.

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Dronedarone Safely Treats Concomitant AF and HF With Preserved or Mildly Reduced Ejection Fraction

ECG with supraventricular extrasystole and short paroxysm of atrial fibrillation

A post hoc analysis of the ATHENA trial has determined that dronedarone has benefits in patients whose atrial fibrillation or atrial flutter is complicated by heart failure with preserved ejection fraction or heart failure with mildly reduced ejection fraction.

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Reprogramming of Smooth Muscle Cells May Facilitate Blood Vessel Repair

Microscopic image of human heart muscle

Researchers at Brigham and Women’s Hospital have published a proof-of-principle study showing vascular smooth muscle cells themselves can be transformed into endothelial cells.

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New Treatment Strategy Proposed for Rheumatic Heart Valve Disease

Close up of valve replacement surgery where artificial valve is being implanted

Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.

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Timing of High-grade PVCs During Stress Testing Stratifies Risk of Cardiovascular Mortality

Electrocardiogram revealing premature ventricular contractions

Brigham and Women’s Hospital researchers investigated the prognostic value of premature ventricular contractions (PVCs) in asymptomatic individuals not suspected of having heart disease. High-grade PVCs that occurred during recovery from stress testing were associated with long-term cardiovascular mortality.

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Esophagectomy Complication Rate Higher with Low-volume Surgeons Even at the Same High-volume Center

Close up of two surgeons beginning thoracic surgery

A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.

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Exenatide Mini-Pump Demonstrates Cardiovascular Safety in Type 2 Diabetes

3D rendering of exenatide drug molecule

The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.

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Study Explains Why Patients With Diabetes Are Prone to Thrombosis, Suggests New Therapeutic Target

Man puts on compression socks for thrombosis

An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.

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“Enhanced Recovery After Surgery” Pathway Promising for Cardiac Surgery

Male patient lying in hospital bed recovering from surgery

In 2018, a multidisciplinary team at Brigham and Women’s Hospital developed a multimodal enhanced recovery after surgery (ERAS) program to optimize perioperative care in cardiac surgery. They report promising early results in Seminars in Thoracic and Cardiovascular Surgery.

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