Adults With TBI May Benefit From Screening for Cardiometabolic Disease, Other Comorbidities

Female doctor shows brain scan images to older male patient in hospital bed

An analysis of prospectively collected data has demonstrated that adults who sustain traumatic brain injury (TBI), regardless of age and injury severity, are at higher risk of certain cardiovascular, endocrine, neurologic, and psychiatric disorders.


Rates of Spinal Symptoms and Spinal Surgery Are Lower After Bariatric Surgery

Doctor holds up x-ray of spine to show older patient

A study showed patients with a history of bariatric surgery had lower overall complication rates after spinal surgery than morbidly obese patients who did not have bariatric surgery. Now researchers report significant reductions in symptomatic spinal disorders and the need for spinal surgery after bariatric surgery.


Menopausal Hormone Therapy Linked to Increased Risk of Pituitary Adenoma

Woman sitting down holding a pack of menopausal hormone therapy pills

David J. Cote, MD, PhD, and Meir J. Stampfer, MD, DrPH, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, and colleagues have conducted the first prospective study of associations between pituitary adenoma and the use of oral contraceptives or menopausal hormone therapy.


Novel POSE Techniques Developed at the Brigham Are Safe and Effective

Close up of doctor holding endoscopic examination tool before surgery

In 2018, Pichamol Jirapinyo, MD, MPH, and Christopher C. Thompson, MD, developed a modified technique they call distal POSE—which involves placing plications primarily in the gastric body, sparing the fundus. They have published a one-year study, concluding distal POSE appears safe and effective for treating obesity.


The Prevention Sweet Spot: Optimizing Treatment for Type 2 Diabetes

A group of colleagues standing together at a conference

Vanita Aroda, MD, associate physician in the Division of Endocrinology, Diabetes and Hypertension, has served as a clinical researcher and clinical trialist for countless studies focused on preventing and treating type 2 diabetes. She discusses her involvement in the SELECT, PIONEER 1, REVITALIZE 1, and other trials.


Plication Transoral Outlet Reduction Safely Treats Weight Regain After Gastric Bypass

Close up measuring waist with measuring tape

Endoscopists at Brigham and Women’s Hospital have conducted the first study in which plication endoscopic transoral gastric outlet reduction was combined with argon plasma coagulation to treat weight gain after Roux-en-Y gastric bypass.


Blood Test Offers Better Prediction of Preeclampsia Risk

Researcher in lab setting selecting from upright plasma samples on table

Researchers have shown that a novel molecular signature from a single blood sample can identify women at risk of preeclampsia months before presentation. They also report that molecular signatures accurately track gestational age, independently of clinical factors, and could advance the study of other complications.


Two-Way Communication Necessary to Re-engage Patients in Diabetes Care After Major Disruption

Close up of woman typing on phone with agenda book open on table

When the COVID-19 lockdown began, the Brigham’s Diabetes Management Program developed a protocol for reaching out to patients whose routine clinic visits were abruptly canceled. A study led by Marie E. McDonnell, MD, revealed two-way communication was necessary to re-engage patients in diabetes care after disruption.


Adjustable Intragastric Balloon Permits Individualized Weight Loss Therapy

3D rendering concept of a gastric balloon inside a stomach

In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.


Study Reveals Evidence of Peripheral Circadian Clocks in Humans

3D rendering of hypothalamus in brain where the suprachiasmatic nucleus is located

Brianne A. Kent, PhD, Steven W. Lockley, PhD, and colleagues hypothesize that peripheral clocks exist in humans. They report that the circadian rhythms of certain peripheral metabolic markers—lipids and liver proteins—differ from that of melatonin, a principal marker of central pacemaker activity.