Denosumab Use for Osteoporosis May Reduce Risk of Type 2 Diabetes

Close up of doctor holding syringe, denosumab medical injection concept

Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.


Transoral Outlet Reduction Plus Pharmacotherapy Superior to Either Alone for Treating Weight Regain After RYGB

Brigham and Women’s Hospital researchers, and colleagues investigated the effect of combining pharmacotherapy with transoral outlet reduction. They demonstrate the combination is superior to either therapy alone and provides similar efficacy to surgical revision for weight gain after Roux-en-Y gastric bypass.


Healthy Lifestyle Linked to Lower Risk of Microvascular Complications of Diabetes

Using two large prospective cohorts, Brigham and Women’s Hospital researchers have demonstrated that adherence to healthy practices both before and after a diabetes diagnosis is significantly associated with lower risk of microvascular complications.


Peak Total and Free Testosterone in Women of Reproductive Age Are Higher Than Previously Reported

3D rendering of testosterone molecule, ball-and-stick molecular model

Measuring serum testosterone (T) levels in women aids in the diagnosis of disorders of androgen excess. Brigham and Women’s Hospital researchers examined changes in T and dihydrotestosterone levels, reporting higher levels of total and free T and emphasizing the need for menstrual phase–specific reference ranges.


Safety and Tolerability of Semaglutide: Pooled Phase 3 Data

Close up of woman injecting insulin into stomach

Brigham and Women’s Hospital researchers report an integrated analysis of 18 randomized, controlled trials of semaglutide (17,639 patients), concluding its safety and tolerability are now well characterized—and similar for the subcutaneous and oral formulations.


Hyperkalemia During Renin–Angiotensin–Aldosterone System Inhibitor Therapy Linked To Poorer Outcomes

A photograph of a tall peak T type cardiac electrodes that can tell if a patient has Hyperkalemia.

Hyperkalemia is one of the most common adverse reactions to renin–angiotensin–aldosterone system inhibitor (RAASi) therapy. In a recent study, Brigham and Women’s Hospital researchers found that patients who develop hyperkalemia while receiving RAASi therapy have a higher risk of poor outcomes.


Review: Efficacy and Safety of Testosterone for Older Adults With Functional Limitations

Close up of old man's hands holding wooden cane, seated

Testosterone is a leading candidate for preventing and treating age-related loss of muscle mass, strength, power, and physical function. In this review, Brigham and Women’s Hospital researchers critically appraise several suppositions about using testosterone in older adults with functional limitations.


ENDO 2023: Brigham Leaders Present Latest Endocrinology Advancements

View from behind Audience at a conference hall, person presenting at podium

Leaders from the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital are honored to join international colleagues at the world’s premier event in endocrinology research and clinical care: the Endocrine Society Annual Meeting. ENDO 2023 takes place June 15–18 in Chicago, IL.


Embedding Diabetes Care in the Latino Community

Headshot of A. Enrique Caballero, MD on gray background

The Brigham’s new approach to providing diabetes care for Latino/Hispanic patients involves embedding diabetes specialists in community clinics and offering culturally and linguistically appropriate services to help patients control their disease and its complications, as A. Enrique Caballero, MD, explains.


Endoscopic Gastric Plication Reduces Fibrosis in Patients With Obesity and NAFLD

Close up Doctor point out the computer screen, report of gastrointestinal endoscopy, medical imaging EGD looking for structures in the esophagus.Medical image concept.

Researchers at Brigham and Women’s Hospital have linked endoscopic gastric plication (also called distal primary obesity surgery endoluminal, or POSE) to significant improvement in liver-related outcomes in patients with obesity, nonalcoholic fatty liver disease, and clinically significant hepatic fibrosis.