Stark Differences Found in Hospital-level Patterns of Nonoperative Management for Low-risk Thyroid and Kidney Cancers

A growing set of low-risk cancers, including early-stage thyroid and kidney cancers, is associated with excellent outcomes regardless of management strategy. Given the risks associated with overtreatment of these cancers, it follows that many patients should be treated nonoperatively. Read More

Women Substantially More Likely Than Men to Decline Statin Therapy

Female doctor shows elderly female patient something on paper in doctor's office, diagnosis concept

In the first large, population-based cohort study of the issue, researchers at Brigham and Women’s Hospital found 22% of eligible patients declined statin therapy initially and 6% never accepted the recommendation. Results on both measures were significantly higher for women than men.


Primary Aldosteronism: A Prevalent, Yet Grossly Underrecognized Cause of Hypertension

Heart monitor measuring vital signs, 154 bpm, hypertension concept

The Brigham’s Anand Vaidya, MD, MMSc, and Jenifer Michelle Brown, MD, have led studies showing that primary aldosteronism (PA) is much more prevalent than assumed—and may be a causative mechanism for 15%–24% of primary hypertension cases. Now, they are expanding PA screening among high-risk patient populations.


Benefits of Electronic Health Records in the Management of Hypogonadal Men

Doctor working on laptop computer and medical stethoscope on clipboard on desk, EHR concept

Electronic health records (EHRs) have multiple benefits for both clinicians and patients, but can lead to clinician burnout. Martin Kathrins, MD, and Anna Goldman, MD, of Brigham and Women’s Hospital, discuss how EHRs can optimize the treatment of hypogonadal men.


LSD1 Modifies Aldosterone Synthesis in a Sex-specific Manner

3d rendered medical illustration of a woman's adrenal glands highlighted orange

Brigham researchers reinforce previous studies showing LSD1 heterozygote knockout mice displayed altered aldosterone secretion/MR activation in an age- and sex-dependent manner, and for the first time, they report that even at the level of aldosterone biosynthesis, there is an effect of biological sex.


Stepwise Approach for Use of Thyrotropin Receptor Antibody Tests

3D rendering of thyroid gland highlighted inside the neck

Researchers in the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital found thyroid-stimulating immunoglobulin bioassay (TSI) and thyrotropin-binding inhibitory immunoglobulin assay (TBII) performed similarly for discriminating Graves’ disease from other causes of thyrotoxicosis.


Novel Text Messaging Program Encourages Women With Gestational Diabetes to Self-Monitor Their Glucose

Over the shoulder view of woman outside texting on smartphone

Brigham and Women’s Hospital team has developed an automated two-way text messaging program designed to encourage self-monitoring of blood glucose in women with gestational diabetes mellitus.


The Brigham Presents Updates in Hypertension Among Older Adults at Medical Grand Rounds Panel

Doctor monitoring blood pressure of older male patient, hypertension concept

In this Medical Grand Rounds presentation, Naomi D.L. Fisher, MD, of Brigham and Women’s Hospital, joined a panel of colleagues from the Boston area to discuss recent developments in the diagnosis and treatment of hypertension among older adults.


Mineralocorticoid Receptor Antagonists Have No Meaningful Role in Treating Primary Hyperparathyroidism

Aldosterone scientific molecular model, 3D rendering

Colleagues from the Brigham’s Center for Adrenal Disorders assessed the efficacy of aldosterone antagonism with a mineralocorticoid receptor (MR) antagonist versus placebo in patients with primary hyperparathyroidism (P-HPT). They provide evidence that MR antagonists have no meaningful role in P‐HPT treatment.


MKRN3 Gene Linked to Delayed Puberty

3D rendering of colorful DNA sequences in and out of frame, gene concept

Based on findings from a novel mouse model, researchers at Brigham and Women’s Hospital led by Ursula B. Kaiser, MD, suggest that genetic variants resulting in increased MKRN3 expression may be a previously unrecognized cause of delayed puberty.