Latest Clinical & Research News
Specialty: Endocrinology
A recent pooled analysis of randomized trials co-led by Brigham and Women’s Hospital researchers indicates that patients with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to patients who received medical management plus lifestyle interventions.
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Vanita Aroda, MD, director of Diabetes Clinical Research at Brigham and Women’s Hospital, and colleagues report data from the latest study in the PIONEER clinical trial program that suggests higher doses of semaglutide are safe and efficacious for adults with type 2 diabetes who need additional glycemic control.
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Obstetrician Louise Wilkins-Haug, MD, PhD, and endocrinologist Ellen Seely, MD, are leaders at the Brigham’s Center for Connected Postpartum Care. The pair discusses the need for this center, its multidisciplinary approach to care, and its early successes in managing hypertensive patients postpartum.
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After analyzing data from pivotal trials, researchers at Brigham and Women’s Hospital believe treatment with a combination SGLT2i, GLP-1 RA, and nonsteroidal MRA has the potential to improve survival in patients with type 2 diabetes and at least moderately increased albuminuria.
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The Brigham was part of a trial that shows for the first time that the weight loss drug semaglutide lowers the incidence of death from cardiovascular causes in those with overweight or obesity but not diabetes. Jorge Plutzky, MD, discusses the findings and implications for clinical care.
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Using contemporary data sets reflecting current clinical practices, researchers at Brigham and Women’s Hospital developed the TIMI Risk Score for Atherothrombosis in Diabetes, which uses information readily available from the medical chart to predict atherothrombotic complications in patients with type 2 diabetes.
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Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.
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Brigham and Women’s Hospital researchers, and colleagues investigated the effect of combining pharmacotherapy with transoral outlet reduction. They demonstrate the combination is superior to either therapy alone and provides similar efficacy to surgical revision for weight gain after Roux-en-Y gastric bypass.
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Using two large prospective cohorts, Brigham and Women’s Hospital researchers have demonstrated that adherence to healthy practices both before and after a diabetes diagnosis is significantly associated with lower risk of microvascular complications.
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Measuring serum testosterone (T) levels in women aids in the diagnosis of disorders of androgen excess. Brigham and Women’s Hospital researchers examined changes in T and dihydrotestosterone levels, reporting higher levels of total and free T and emphasizing the need for menstrual phase–specific reference ranges.
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