Studying New Approaches for Immunotherapy in Renal Cancer

illustration of organ

Immunotherapy with checkpoint inhibitor drugs is an emerging treatment for renal cell carcinoma. Now investigators from Brigham and Women’s Hospital have reported the results from lab research looking at a potential new way to boost the immune system’s ability to fight cancer.

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Using Nanoparticles to Target Renal Cell Carcinoma

nanoparticlesTargeted therapy has had much less success in treating renal cell carcinoma than in treating many other kinds of cancer. Physician-scientists at Brigham and Women’s Hospital are working on several innovative approaches to address this shortfall.

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Uncovering Risks for Severe AKI in COVID-19 Patients

Dialysis machine

Infection with SARS-CoV-2 can affect any organ system in the body, and acute kidney injury (AKI) is common in people with more severe cases of COVID-19. Researchers at Brigham and Women’s Hospital recently led a study that looked at critically ill patients with COVID-19 and identified both patient- and hospital-level risk factors for development of AKI treated with dialysis.

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Examining Impact of Race in Staging Chronic Kidney Disease

Patient getting dialysis

An equation used for over a decade to estimate kidney function and stage chronic kidney disease (CKD) can underestimate kidney function and lead to gaps in care delivery in African-American patients, according to research led by investigators at Brigham and Women’s Hospital.

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First Nationwide Study of Critically Ill COVID-19 Patients

anesthetist with patient

Investigators at Brigham and Women’s Hospital led the first study that offers national data on the factors that may increase the risk of complications or death in critically ill COVID-19 patients. David E. Leaf, MD, MMSc and Shruti Gupta, MD, MPH, physicians in the Brigham’s Division of Renal Medicine, led a team of more than 300 investigators from over 65 hospitals across the U.S. to examine the demographics, comorbidities, organ dysfunction, treatment and outcomes of patients with COVID-19 admitted to intensive care units (ICUs). Read More

Managing Acute Kidney Injury in COVID-19 Patients

 

machine hooked up to wiresAt Brigham and Women’s Hospital, nephrologists have observed an increased risk of acute kidney injury (AKI) in COVID-19 patients. Within the intensive care units (ICUs) at the Brigham, about 15 to 20 percent of COVID-19 patients have developed AKI. In some hospitals, the incidence of AKI has been reported to be as high as 25 percent.

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Strong Progress Made in Kidney Replacement Therapy Program

Three panel image of stereolithographic 3D bioprinting of a dog kidney
Stereolithographic 3D bioprinting (left two panels) of a dog kidney nephron (right panel).

The once-long road to developing a viable alternative to kidney dialysis has become a little shorter thanks to strides made by a unique public-private partnership.

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New Therapeutic Strategy for Toxic Proteinopathies

illustration of a small moleculeA small molecule discovered by researchers at Brigham and Women’s Hospital may hold promise for treating mucin-1 kidney disease (MKD) as well as other toxic proteinopathies of the brain, eye, lungs and liver. These diseases are driven by genetic mutations that result in misfolded, “toxic” proteins that in turn become trapped and accumulated in cells.

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Acute Kidney Injury Associated With Immune Checkpoint Inhibitors

acute kidney injury

Researchers at Brigham and Women’s Hospital have identified several links between the use of immune checkpoint inhibitors (ICPIs) and acute kidney injury (AKI). The risk factors, clinicopathologic features, treatment and long-term outcomes in patients with ICPI-associated AKI, as well as the risk of recurrent AKI with ICPI rechallenge, are detailed in a multicenter study recently published in the Journal of the American Society of Nephrology. These newly identified links will help guide oncologists in treating patients with ICPIs.

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Interventional Nephrology Service Speeds and Improves Care for Dialysis Patients

person receiving dialysis

Brigham and Women’s Hospital has been on the forefront of nephrology for decades: in 1954, the hospital was the site of the first successful living-donor kidney transplant. Today, the Brigham continues its legacy of innovation in kidney dialysis research and care through its Interventional Nephrology service at Brigham and Women’s Faulkner Hospital, one of the few programs of its kind in the country.

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