Nationwide Study Clarifies Risk Factors for Sepsis After Vertebral Fracture Repair

CT Scan of head and spine with a vertebral fracture highlighted in red

No standardized risk tool is available for predicting the risk of sepsis in patients who undergo vertebral fracture repair for traumatic spinal injury. To address this knowledge gap, Hasan A. Zaidi, MD, and colleagues explored clinical correlates of sepsis in a large nationwide U.S. cohort.


Study Reveals Evidence of Peripheral Circadian Clocks in Humans

3D rendering of hypothalamus in brain where the suprachiasmatic nucleus is located

Brianne A. Kent, PhD, Steven W. Lockley, PhD, and colleagues hypothesize that peripheral clocks exist in humans. They report that the circadian rhythms of certain peripheral metabolic markers—lipids and liver proteins—differ from that of melatonin, a principal marker of central pacemaker activity.


22q11.2 Deletion, Duplication Linked to Opposing Changes in White Matter

3D color medical concept of human brain white matter

Ofer Pasternak, PhD, and Johanna Seitz-Holland, MD, PhD, of the Department of Psychiatry at Brigham and Women’s Hospital, and colleagues conducted the first study to compare white matter in 22q-del and 22q-dup, and report finding opposing abnormalities that might indicate distinct pathologies.


Exploring the Role of Neurons in the Tumor Microenvironment that Drive Cancer Growth

Humsa Venkatesh, PhD, a cancer biologist, is studying the neural regulation of cancer and how nervous system cells found within the tumor microenvironment drive tumor growth. Her research has implications for primary brain tumors such as gliomas and for tumors that metastasize to the brain from other parts of the body.


WEB Embolization: Transradial and Transfemoral Access Are Comparably Safe, Effective

CT Scan Axial View of Brain to Detect Aneurysm

Mahmoud Dibas, MD, and Adam A. Dmytriw, MD, MPH, MSc, at Brigham and Women’s Hospital, and colleagues used data from a large multicenter study to compare transradial access with transfemoral access for WEB embolization. They report the two approaches were associated with comparable radiologic and clinical outcomes.


Cranial Nerve Imaging Abnormalities in Patients With Hereditary Neuropathies Can Mimic Otolaryngologic Problems

Doctor points to brain scan images to detect abnormalities

C. Eduardo Corrales, MD, Ryan A. Bartholomew, MD, and colleagues detected a 21% prevalence of radiologic cranial nerves abnormalities in patients with hereditary neuropathies who underwent MRI. They caution physicians not to assume these findings represent pathologies requiring intervention by an otolaryngologist.


Novel Transcranial Doppler Screening Approach Identifies Risk of Radiological Delayed Cerebral Ischemia

Transcranial Doppler examination searching for vasospasm after subarachnoid hemorrhage

Samuel B. Snider, MD, Ibrahim Migdady, MBBS, Rose Du, MD, PhD, of Brigham and Women’s Hospital, and colleagues found the severity of transcranial doppler screening-measured vasospasm predicts radiological delayed cerebral ischemia in a vessel-specific manner.


Brigham Neurosurgery Leads Revival in the Use of Ultrasound for Brain Tumor Resection

Dr. Golby and Team Using Ultrasound in Operating Room

Intraoperative magnetic resonance imaging is an extremely useful tool in guiding surgical brain tumor resection but also has significant drawbacks. The Brigham’s Department of Neurosurgery is turning to an older alternative: ultrasound. Alexandra J. Golby, MD, director of image-guided neurosurgery, explains.


Brain Circuit Mapping Refines Targets for Neurostimulation

Researchers at Brigham and Women’s Hospital have developed a novel brain mapping method that suggests lesions, TMS and DBS converge on a common brain circuit for depression—which may represent a better target for therapeutic neurostimulation. The approach seems to be generalizable to other neuropsychiatric diseases.