Making Progress in Creating a New Standard of Care for Essential Tremor

Woman sitting on bed holding glass with shaking hand, suffering from essential tremor

Propranolol, the current standard of care for essential tremor (ET), has significant shortcomings in efficacy and safety. As medicinal chemist Kevin Hodgetts, PhD, explains, Brigham investigators are developing novel therapies for ET patients by applying innovative drug design concepts to validated disease targets.


Brigham Leads Development of Surgical Techniques for Treating AVM

<em>4 Angiograms and MRI images show an arteriovenous malformation (AVM) in a patient before surgery</em>

The Brigham’s AVM Program aims to provide the best possible nonsurgical and surgical treatment options for people with brain arteriovenous malformations (AVMs). Director Nirav J. Patel, MD, discusses his team’s use of an innovative surgical technique to treat AVM and efforts to set up similar programs internationally.


Focused Ultrasound Facilitates Delivery of Anti-Amyloid Antibody in Mouse Model of Alzheimer’s Disease

Amyloid plaques forming between neurons in a brain with Alzheimer's disease

Researchers at Brigham and Women’s Hospital are investigating therapeutic focused ultrasound to enhance antibody delivery to the brain when treating Alzheimer’s disease.


Meta-analysis: Stroke Response Times Early in COVID-19 Depended on Metric, Type of Center

Elderly man in wheelchair in front of hospital windows, with female nurse wearing mask and gloves

Delays in stroke treatment were inevitable during the early months of the COVID-19 epidemic, given virus-related precautions and the massive influx of COVID-19 patients into hospitals. Understanding the precise extent of those delays is important to learn what factors lead to late care.


Cognitive Deficits Present Across Domains in Schizophrenia and Relate to Positive Symptoms

Young woman on couch, emotional, talking with female researcher or doctor who holds a clipboard

Johanna Seitz-Holland, PhD, Marek Kubicki, MD, PhD, of the Department of Psychiatry at the Brigham, and colleagues recently became the first to investigate cognitive deficits in schizophrenia in a large-scale, thoroughly harmonized sample.


Penetrating the Blood-Brain Barrier to Improve Efficiency of Gene Therapy Delivery

3D illustration of adeno-associated viruses, used in gene cell therapy

The Brigham’s Fengfeng Bei, PhD, and team have reported on a new adeno-associated virus variant that delivers gene therapy across the blood-brain barrier in non-human primates more efficiently than previously developed vehicles. It could have implications for treating neurodegenerative diseases including Alzheimer’s.


Both Clinical Features, Assay Results Need Consideration in Diagnosis of MOG-AD

Demyelination of neuron, the damage of the neuron myelin sheath seen in demyelinating diseases

Giovanna S. Manzano, MD, of the Department of Neurology at Brigham and Women’s Hospital, Marcelo Matiello, MD, of Massachusetts General Hospital, and colleagues determined positive predictive values of a live cell–based serum assay that detects the diagnostic biomarker for MOG-AD in a real-world cohort.


New Cell Atlas Poised to Support Development of Migraine Therapies

Young woman gripping head in pain from migraine, in home office

Brigham investigators have mapped out a group of cells in the trigeminal ganglia that drive migraine pain, allowing them to further characterize the cells in a way that holds promise for developing new therapeutics. Neurologist and lead author William R. Renthal, MD, PhD, elaborates on the study.


CRP-to-Albumin Ratio Reflects Risk of Adverse Events After Spinal Epidural Abscess Treatment

MRI of cervical spine showing epidural abscess that causes spinal cord compression and paralysis

Matthew H. Lindsey, MD, Andrew J. Schoenfeld, MD, MSc, of the Department of Orthopaedic Surgery at Brigham and Women’s Hospital, and colleagues have published putative evidence that the C-reactive protein to albumin ratio can help predict adverse events after spinal epidural abscess treatment.


Newly Identified Role of α-Synuclein May Lead to Novel Parkinson’s Disease Therapy

3d illustration of nerve cell with abnormal protein accumulations, lewy bodies

Vikram Khurana, MD, PhD, and colleagues have discovered an additional function of α-Synuclein—it modulates the stability of mRNA, thereby regulating gene expression. They explain the implications for understanding normal cellular physiology and developing therapies for Parkinson’s disease and related disorders.