Economic Burden of Neuromyelitis Optica Spectrum Disorders Quantified From Patient Point of View

Brigham and Women’s Hospital researchers recently conducted the first study of patient-reported data on the economic burden of neuromyelitis optica spectrum disorders (NMOSD). Specifically, they characterized the direct and indirect costs of relapse events (ED visits and hospitalizations).


People Have “Massive” Memory for Where and When They Saw Something

Researchers at Brigham and Women’s Hospital have shown more specifically that humans have a spatial massive memory—they can remember where they saw objects presented briefly—and a temporal massive memory—they can remember when they saw the objects.


Delirium Superimposed on Dementia During Hospitalization Has Complex Effect on Costs

senior male patient with IV

Tammy T. Hshieh, MD, MPH, and colleagues recently explored from a healthcare system perspective the direct costs of delirium in hospitalized patients with and without Alzheimer’s disease or a related disorder.


Somatic Variants in Supervillin Increase Susceptibility to Cerebral Aneurysms

Human brain 2d digital illustration

Researchers at Brigham and Women’s Hospital recently reported that somatic variants—specifically, in the supervillin (SVIL) gene—increase susceptibility to intracranial aneurysms through changes in vascular smooth muscle cells (vSMCs).


AAN 2023: Brigham Neurologists Present Latest Research

3d rendering of a brain

On April 22–27, 2023, the American Academy of Neurology hosts its 75th annual meeting in Boston, MA and virtually. Leaders from the Department of Neurology at Brigham and Women’s Hospital will present their latest research at the meeting alongside international colleagues.


Brigham Neurosurgery at the AANS 2023 Annual Scientific Meeting

Neurosurgeon in special surgery glasses performing operation

Experts from the Department of Neurosurgery at Brigham and Women’s Hospital join other neurosurgical leaders at this year’s AANS Annual Scientific Meeting, “Neurosurgeons as Advocates,” held April 21 – 24, 2023, in Los Angeles, CA.


Anterior Temporal Lobectomy Has Clear Utility in Medically Refractory Herpes Simplex Virus Encephalitis

Herpes simplex virus (HSV) is the most common cause of viral encephalitis. The brain lesions in HSV encephalitis (HSVE) primarily involve the temporal and frontal lobes. About half of patients develop seizures, which may progress to chronic seizure disorders or status epilepticus.


Palmitoylation of Syt11 Explains Parkinson’s Disease Risk, May Be Targetable

Gary P.H. Ho, MD, PhD, neurologist in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital, Dennis J. Selkoe, MD, co-director of the Center, and colleagues suspected there might be a functional link between Syt11 and αS in the context of Parkinson’s disease.


Novel Localization of MS-related Depression May Allow Therapeutic Brain Stimulation

Researchers at Brigham and Women’s Hospital recently demonstrated that lesions causing depression in patients with stroke or penetrating head trauma were functionally connected to a common brain circuit.


Review: Precision Medicine for Multiple Sclerosis

Key decision points in multiple sclerosis (MS) management would benefit from precision medicine—using information about an individual’s genomics, environment, and lifestyle, not just their signs and symptoms—to subtype their disease and make personalized decisions about their treatment.