Case Reports: Novel Congenital Spinal Cord Malformation Not Requiring Neurosurgery

Double face. Split personality. Mood disorder. 2 Head silhouette.Psychology. Dual personality.

Physicians at Brigham and Women’s Hospital have encountered two newborn infants with a novel syndrome they believe arises from errors in notochord formation. They report its clinical and radiographic characteristics, describe their treatment approach and theorize about the embryogenesis of the malformation.


Use of Multiple Control Tissue Types Recommended for Molecular Studies of Cerebrovascular Diseases

3d rendered medically accurate illustration of the head anatomy

Researchers at Brigham and Women’s Hospital determined the middle cerebral artery, circle of Willis, and paired superficial temporal artery (STA) are all feasible control vessels for transcriptomic studies of cerebrovascular diseases.


Blood Tests May Identify Which Patients With Stable MS Can Discontinue Treatment

close up picture of dripping liquid from pipette into test tube

Serum biomarkers are becoming increasingly investigated for risk profiling in MS. Researchers at Brigham and Women’s Hospital have found that changes in two of them after treatment is stopped can signal impending disease activity.


Parkinson’s Disease Therapies: Genomic Insights and Stem-Cell Innovations

Clinicians and clinician-investigators in the Division of Movement Disorders in the Department of Neurology at Brigham and Women’s Hospital are taking various approaches to provide specialty care for patients facing a broad range of diseases that affect movement, including Parkinson’s disease.


Comprehensive Study Categorizes Economic Consequences of Stroke on the Global, Regional and Country Levels

Researchers at Brigham and Women’s Hospital recently completed the first study that assessed the macroeconomic consequences of stroke and its subtypes globally in a standardized way.


Preoperative Alzheimer’s Disease and Related Dementias Influence Outcomes of Colorectal Surgery

Joel S. Weissman, PhD, of Brigham and Women’s Hospital, Clancy J. Clark, MD, of Wake Forest Baptist Health, and colleagues say patients with ADRD required longer hospital stays, were more likely to be readmitted, and were more likely to have postoperative complications than patients with normal cognitive function.


Serum-based Assay Validated for Care of Patients With MS

Researchers at Brigham and Women’s Hospital developed the Multiple Sclerosis Disease Activity (MSDA) Test, a multiprotein, serum-based biomarker assay for MS diagnosis, and have reported clinical validation of the assay.


Tumor Treating Fields Reconceptualized As Targeted Implanted Therapy for Complex High-Grade Glioma

Researchers at Brigham and Women’s Hospital believe an implanted intracranial stimulation system could increase both the strength and duration of tumor treating fields (TTF) delivery.


Case Report: Closed-Loop Neurostimulation of Multiple Thalamic Nuclei Controls Seizures

Closed-loop systems allow for concurrent sampling and modulation of extended thalamic networks. Researchers at Brigham and Women’s Hospital have become the first to capture continuous recordings of seizure activity from multiple thalamic nuclei using a closed-loop neurostimulation system.