COVIDprotocols.org: A New Approach to Developing Clinical Guidelines During a Crisis

COVIDprotocols.org, the world’s first and most comprehensive searchable website for step-by-step COVID-19 clinical guidelines, has its roots at the Brigham. Managing editor Edy Yong Kim, MD, PhD, of the Division of Pulmonary Care and Critical Care Medicine, provides a behind-the-scenes look at this valuable resource.

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Technical Note: Thoracoscopic Radial Diaphragm Plication

Medical hand reaching for surgical tools

Numerous approaches to diaphragm plication procedures have been reported, with no consensus on the ideal technique. Surgeons at Brigham and Women’s Hospital have developed a radial diaphragm plication technique that makes use of thoracoscopic instruments to increase lung volume with long-term benefits.

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Novel Metrics for GERD Evaluation Have Prognostic Value in Idiopathic Pulmonary Fibrosis

Older woman holding chest, GERD symptoms/discomfort

Previous studies of GERD have relied on multichannel intraluminal impedance and pH testing, which has substantial limitations including the need to count reflux episodes. Now, researchers at Brigham and Women’s Hospital have linked more advanced impedance metrics to the prognosis of patients with IPF.

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Respiratory Tract Diseases May Increase Risk of RA Years Before Onset

Close up of hands affected by rheumatoid arthritis

There is growing evidence that rheumatoid arthritis (RA) originates in mucosal surfaces and a range of respiratory tract diseases are associated with RA. Now, researchers have demonstrated that the timing of respiratory tract disease diagnosis significantly affects the strength of each disease’s association with RA.

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High Prevalence of Parenchymal Lung Diseases in Patients With Rheumatoid Arthritis

CT scan of patient with emphysema in the lungs

Tracy J. Doyle, MD, Jeffrey A. Sparks, MD, MMSc, and colleagues identified a high prevalence of undiagnosed preclinical parenchymal lung disease in a rheumatoid arthritis cohort, with important clinical implications.

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Esophagectomy Complication Rate Higher with Low-volume Surgeons Even at the Same High-volume Center

Close up of two surgeons beginning thoracic surgery

A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.

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Preoperative Risk Factors Identified for Prolonged Air Leaks Requiring Intervention

X-ray of patient with upper lung resection

Researchers at the Brigham, including Matthew M. Rochefort, MD, and Aaron R. Dezube, MD, of the Division of Thoracic and Cardiac Surgery, and colleagues retrospectively studied a large series of patients undergoing lung resection to determine the incidence of severe prolonged air leaks and its risk factors.

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Sinonasal and Asthma Symptom Severities Correlated in Aspirin-exacerbated Respiratory Disease

Woman with asthma uses inhaler

Using prospectively collected registry data, researchers at Brigham and Women’s Hospital linked increased severity of sinonasal symptoms in patients with aspirin-exacerbated respiratory disease to both worse patient-reported asthma control and worse objectively measured lung function.

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Pulmonary Microbiome May Identify Patients With High-risk Lymphangioleiomyomatosis

CT Scan of a patient with LAM

Souheil Y. El-Chemaly, MD, and Julie Ng, MD, of Brigham and Women’s Hospital, and colleagues conducted the first study to examine the lung microbiome of patients with lymphangioleiomyomatosis (LAM) who were at high risk of disease progression or death.

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Active Lifestyle May Reduce Incidence of Obstructive Sleep Apnea

Yue Liu, MD, a research fellow at the Brigham, Tianyi Huang, ScD, an associate epidemiologist, and colleagues have linked physical inactivity and sedentary behavior with obstructive sleep apnea incidence, suggesting an active lifestyle may have a role in prevention.

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