Novel Method of Delivering Therapeutic CO Fights Inflammation

Medically accurate rendering of inside an inflammed colon

Giovanni Traverso, MD, PhD, MBBCH, of Brigham and Women’s Hospital and MIT, and colleagues have incorporated CO into gas-entrapping materials (GEMs) that can be delivered safely to the digestive tract.

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Oil-based Gels Are Versatile Drug Delivery Systems for Pediatric Applications

Male pediatrician listening to boy's heart through stethoscope in medical setting

Ameya Kirtane, PhD, and Giovanni Traverso MD, PhD, MBBCH, and colleagues have developed oleogels—gels made from food-based oils—that can be used to deliver drugs to children. They report oleogels may perform similarly to or better than commercial tablets.

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Telemedicine Extends Brigham’s Rich History of Neurosurgical Innovation to Underserved Areas

Woman wearing mask sitting on couch holding up tablet with female doctor on telemedicine video call

Advances in telemedicine are enabling the Brigham to bring high-quality neurosurgical care to patients nationally and internationally. Timothy R. Smith, MD, PhD, MPH, of the Department of Neurosurgery, discusses how these efforts reflect the broader movement to meet patients’ right to healthcare globally.

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STEMI Rare in Patients Hospitalized With COVID-19, but Prognosis Is Poor

Close up of white graph paper from electrocardiogram showing ST-elevation

Researchers at Brigham and Women’s Hospital recently completed the first large multicenter study of the incidence of ST-segment–elevation myocardial infarction (STEMI) as a complication of COVID-19. STEMI was rare in 0.35% of patients but was associated with poor in-hospital outcomes and high mortality.

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Higher-Dose Vupanorsen Significantly Reduces Non–HDL-C, Other Lipid Parameters

3D color molecular model rendering of ANGPTL3, an antisense oligonucleotide found in the liver

A potential cardiovascular benefit of vupanorsen would best be reflected by its effects on non–high-density lipoprotein cholesterol (non–HDL-C) and apolipoprotein B (ApoB). Brigham researchers studied vupanorsen at higher doses and observed significant reductions in non–HDL-C at all doses studied.

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Reduction of Atrial Fibrillation Burden Is a Worthwhile Therapeutic Target in HFpEF

ECG heart rhythm recording on white paper showing atrial flutter, with gold stethoscope on top

In a post hoc analysis of the PARAGON-HF trial, Scott D. Solomon, MD, of the Division of Cardiovascular Medicine at Brigham and Women’s Hospital, and colleagues evaluated how atrial fibrillation and atrial flutter affected the results.

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Review: Role of Pronator Quadratus Repair in Volar Locking Plate Treatment of Distal Radius Fractures

Rendering of human hand bones with pronator quadratus muscle in anterior compartment of the forearm

Surgeons in the Department of Orthopaedic Surgery at Brigham and Women’s Hospital recently reviewed the evidence for and against pronator quadratus (PQ) muscle repair.

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Could an Intranasal Vaccine Transform Alzheimer’s Prevention and Treatment?

Diagram of Alzheimer's disease with amyloid plaques, neurofilbrillary tangles, and neuronal loss

A groundbreaking intranasal vaccine for Alzheimer’s disease (AD) developed at Brigham shows tremendous promise in its first phase of human trials. Study leader Howard L. Weiner, MD, discusses the trial’s progress to date, planned future phases, and how the vaccine could shape the future of AD care.

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Icosapent Ethyl Reduces Risk of CV Events and Death in Patients With Prior MI

3D atomic rendering of icosapent ethyl

The REDUCE-IT trial found patients at risk had reduced important ischemic events with icosapent ethyl. Prakriti Gaba, MD, and Deepak L. Bhatt, MD, MPH, of Brigham and Women’s Hospital, and colleagues, conducted a post hoc analysis limited to patients in the trial who had a history of myocardial infarction (MI).

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