Can a Fatty Acid Supplement Improve Outcomes in Obese People With Prediabetes?

Yellow oil capsules spilling out of brown bottle onto table

Brigham researchers are looking at novel ways to boost natural mechanisms that the body uses to counteract the pathogenesis of obesity and its complications. An upcoming clinical trial led by Mehmet Furkan Burak, MD, explores the impact of dietary supplementation with palmitoleic acid in obese, prediabetic individuals.


Up to One-Half of Runners Return to Running One Year After Arthroscopic Partial Meniscectomy

3D rendering of human knee bone and cartilage with meniscus tear highlighted red

Researchers at Brigham and Women’s Hospital determined that within one year after arthroscopic partial meniscectomy (APM), approximately 50% of runners return to their preoperative running frequency.


Symptoms of Suspected Laryngopharyngeal Reflux Correlate Poorly With Hypopharyngeal–Esophageal Multichannel Intraluminal Impedance–pH

Woman sitting holding chest and stomach, red highlight on upper chest for reflux discomfort

Sanjay Salgado, MD, Walter W. Chan, MD, PhD, and colleagues recently found no correlation between suspected laryngopharyngeal reflux symptoms and hypopharyngeal–esophageal multichannel intraluminal impedance–pH (HEMII-pH) results.


Novel Method of Delivering Therapeutic CO Fights Inflammation

Medically accurate rendering of inside an inflammed colon

Giovanni Traverso, MD, PhD, MBBCH, of Brigham and Women’s Hospital and MIT, and colleagues have incorporated CO into gas-entrapping materials (GEMs) that can be delivered safely to the digestive tract.


Oil-based Gels Are Versatile Drug Delivery Systems for Pediatric Applications

Male pediatrician listening to boy's heart through stethoscope in medical setting

Ameya Kirtane, PhD, and Giovanni Traverso MD, PhD, MBBCH, and colleagues have developed oleogels—gels made from food-based oils—that can be used to deliver drugs to children. They report oleogels may perform similarly to or better than commercial tablets.


Telemedicine Extends Brigham’s Rich History of Neurosurgical Innovation to Underserved Areas

Woman wearing mask sitting on couch holding up tablet with female doctor on telemedicine video call

Advances in telemedicine are enabling the Brigham to bring high-quality neurosurgical care to patients nationally and internationally. Timothy R. Smith, MD, PhD, MPH, of the Department of Neurosurgery, discusses how these efforts reflect the broader movement to meet patients’ right to healthcare globally.


STEMI Rare in Patients Hospitalized With COVID-19, but Prognosis Is Poor

Close up of white graph paper from electrocardiogram showing ST-elevation

Researchers at Brigham and Women’s Hospital recently completed the first large multicenter study of the incidence of ST-segment–elevation myocardial infarction (STEMI) as a complication of COVID-19. STEMI was rare in 0.35% of patients but was associated with poor in-hospital outcomes and high mortality.


Higher-Dose Vupanorsen Significantly Reduces Non–HDL-C, Other Lipid Parameters

3D color molecular model rendering of ANGPTL3, an antisense oligonucleotide found in the liver

A potential cardiovascular benefit of vupanorsen would best be reflected by its effects on non–high-density lipoprotein cholesterol (non–HDL-C) and apolipoprotein B (ApoB). Brigham researchers studied vupanorsen at higher doses and observed significant reductions in non–HDL-C at all doses studied.


Reduction of Atrial Fibrillation Burden Is a Worthwhile Therapeutic Target in HFpEF

ECG heart rhythm recording on white paper showing atrial flutter, with gold stethoscope on top

In a post hoc analysis of the PARAGON-HF trial, Scott D. Solomon, MD, of the Division of Cardiovascular Medicine at Brigham and Women’s Hospital, and colleagues evaluated how atrial fibrillation and atrial flutter affected the results.