Scientific Statement: Disparities in Lupus Outcomes and the Role of Social Determinants of Health

A recent scientific statement by The Lupus Foundation of America’s Health Disparities Advisory Panel, which includes Karen Costenbader, MD, MPH, addresses the relationship between social determinants of health and racial and ethnic disparities in lupus. It also recommends potential interventions to reduce disparities.

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Patient-reported Autonomic Symptoms Do Not Correlate With Objective Dysfunction

Brigham and Women’s Hospital researchers have confirmed in a large cohort what previous research suggested: a lack of correlation between subjective dysautonomia and standardized objective testing.

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Deep Brain Stimulation Used to Map Therapeutic Targets for Four Brain Disorders

Using deep brain stimulation (DBS) as a research tool, Brigham and Women’s Hospital scientists have identified distinct neural circuits for Parkinson’s disease, dystonia, obsessive-compulsive disorder (OCD), and Tourette’s syndrome.

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Replacement of cTnI With hs-cTnI for Evaluation of Pulmonary Embolism May Misclassify Risk

Behnood Bikdeli, MD, MS, at Brigham and Women’s Hospital, David Jiménez, MD, PhD, at Hospital Ramón y Cajal in Madrid, and colleagues recently conducted the first study to compare the prognostic relevance of cTnI with hs-cTnI in patients with pulmonary embolism (PE).

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Lipidomics Team Receives Ammodo Science Award for Tuberculosis Research

A multi-institutional research group co-led by D. Branch Moody, MD, of Brigham and Women’s Hospital, received an Ammodo Science Award for their groundbreaking research on lipid molecules. Their goal is to develop effective diagnostic tests and vaccines against tuberculosis and other infectious diseases.

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Brigham Researchers Uncover Link Between Metformin and Appetite Suppression

Controlling a newly discovered pathway between the “anti-hunger” molecule N-lactoyl phenylalanine (Lac-Phe) and the widely prescribed diabetes drug metformin could lead to viable strategies to reduce body mass and improve health in millions of people. Lydia Lynch, PhD, and Marie McDonnell, MD, discuss their study.

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Disparities in Fertility Preservation Among Sexually and Gender Diverse Populations

A multidisciplinary team of Mass General Brigham and Harvard Medical School investigators are drawing attention to systemic barriers to fertility preservation among sexually and gender diverse populations.

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Endoscopic Sleeve Gastroplasty Saves Cost Compared With Semaglutide for Class II Obesity

A Brigham and Women’s Hospital study suggests endoscopic sleeve gastroplasty (ESG) is cost-saving compared with semaglutide for class II obesity due to greater effectiveness and lower costs of ESG and increased dropout rates over time with semaglutide.

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A Cellular Model Linking Impaired Neuronal Protein Turnover to Person-Specific Alzheimer’s Disease Risk

Researchers at Brigham and Women’s Hospital are using neurons derived from induced pluripotent stem cells (iNs) as a highly controlled, reproducible model system for understanding cellular pathways that mediate neuropathogenesis directly downstream of genetic risk factors.

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Complication Risk Higher for Patients Who Don’t Meet Clinical Guidelines for Total Joint Arthroplasty

Researchers at Brigham and Women’s Hospital have become the first to examine the sociodemographic characteristics of patients who don’t meet the total joint arthroplasty (TJA) clinical guidelines and their rates of postoperative complications.

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