Exploring the Molecular Mechanisms of Age-Related Muscle Atrophy

Indirect immunofluorescence staining of laminin to assess myofiber morphology

Ronald L. Neppl, PhD, a molecular biologist in the Department of Orthopedic Surgery at Brigham and Women’s Hospital, studies the molecular mechanisms that regulate the balance between anabolic and catabolic processes, and how imbalances in these physiological processes may lead to muscle atrophy.

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Geriatric Co-Management Program for Total Joint Replacement Surgery

Senior woman speaking with doctorFor years, the American College of Surgeons has recommended that elderly patients undergo a geriatric assessment prior to total joint replacement, but many orthopaedic departments in the United States have been slow to adopt the practice.

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Total Hip Arthroplasty: Infection Rates Higher Using Direct Anterior Approach

Total Hip ArthroplastyIn March, the Hip Society presented the 2019 Frank Stinchfield Award to Richard Iorio, MD, and his co-authors, honoring research that compared prosthetic joint infection (PJI)  complication rates between the direct anterior approach (DA) and the non-anterior (NA) approach.

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Improving Perioperative Care in Foot and Ankle Surgery

Doctor giving a patient foot treatment

For over a decade, the Foot and Ankle Service in the Department of Orthopaedic Surgery at Brigham and Women’s Hospital has conducted research that places a strong emphasis on optimizing perioperative care for foot and ankle surgery patients.

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Lower Dose Opioid Regimen Shows Promise for Total Hip Replacement Patients

Senior Woman Taking Medication From Pill Box

In March, the Hip Society presented the 2019 Otto Aufranc Award to Antonia Chen, MD, MBA and her colleagues, honoring their research on opioid usage. Dr. Chen is the senior author of the award-winning paper, “Cluster-Randomized Trial of Opiate-Sparing Analgesia after Discharge from Elective Hip Surgery.”
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An Evidence-based Scoring System for Patients with Metastatic Spine Cancer

Female doctor writing medical records in the officeFor patients with spinal metastases, it remains challenging for providers to choose between operative and nonoperative treatments, especially when life expectancy and quality of life are difficult to predict. At Brigham and Women’s Hospital, Andrew J. Schoenfeld, MD, MSc, and investigators in the Department of Orthopaedic Surgery, are using the New England Spinal Metastasis Score (NESMS) to navigate this complex decision-making process.
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The Brigham Makes The Push Toward Same-Day Joint Replacement

"Arrow sign for outpatient parking in front of parking lot, horizontal with copy space to right."Five years ago, Vivek Shah, MD, a hip and knee replacement surgeon, replaced the right hip of an 85-year-old woman. After the routine surgery, she stayed in the hospital for three days. A few years later, she visited Dr. Shah when she needed her left hip replaced.
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Microendoscopic Surgery Offers Alternative for Spine Patients

microendoscopy image of a spineAt Brigham and Women’s Hospital, spine surgeon Andrew Simpson, MD, focuses a large portion of his practice on microendoscopic spine surgery, a minimally invasive technique used to treat patients with a range of spinal disorders—including disc herniation, spinal stenosis and sciatica.
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When is the Best Time to Measure Glucose During Total Joint Arthroplasty?

Study explores the optimal time to measure glucose levels after TJA

Mid section of doctor examining patient knee in clinic

A periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) is often a devastating experience for a patient, involving a long treatment process that dramatically reduces a patient’s quality of life.

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“Prehab” Program Lowers Length of Hospital Stay by 12 Hours

Closeup shot of an unrecognizable physiotherapist treating a patientFive years ago, Wolfgang Fitz, MD, a knee replacement surgeon in the Department of Orthopaedic Surgery, asked his patients to bridge the two-to-three months prior to surgery with physical conditioning, tailored to their activity levels and knee osteoarthritis.

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