Prospective RCT Finds Full-Dose Anticoagulation Better Than Standard Dose in Severe COVID-19

Female patient on respirator in hospital bed with two doctors monitoring

In COVID-PACT, a 2×2 factorial, randomized, controlled trial that enrolled critically ill patients with COVID-19, researchers at Brigham and Women’s Hospital determined full-dose anticoagulation was superior to standard-dose prophylaxis in reducing the proportion of patients experiencing a thrombotic event.

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Brigham Researchers Create COVID-19 Genome Catalog of the Human Microbiome

3D rendering of the human gut microbiome, with different gut species

Researchers at Brigham and Women’s Hospital analyzed whole-metagenome shotgun (WMS) sequencing data by reconstructing microbial population genomes directly from microbiome samples of COVID-19 patients and controls. They report the creation of the first high-quality COVID-19–related genome catalog of the gut microbiome.

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STEMI Rare in Patients Hospitalized With COVID-19, but Prognosis Is Poor

Close up of white graph paper from electrocardiogram showing ST-elevation

Researchers at Brigham and Women’s Hospital recently completed the first large multicenter study of the incidence of ST-segment–elevation myocardial infarction (STEMI) as a complication of COVID-19. STEMI was rare in 0.35% of patients but was associated with poor in-hospital outcomes and high mortality.

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Video Decision Aids Plus Remote Clinician Training Improved Advance Care Planning During COVID-19

Doctor on video call with older female patient

The need for advance care planning (ACP) was especially heightened for older, Black, and Latino/a/x patients at the onset of the COVID-19 pandemic. Brigham researchers tested an ACP intervention with video decision aids and remote clinician training, reporting improved ACP documentation rapidly and efficiently.

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Holding DMARDs Not Associated With Greater RA Activity After Additional Dose of COVID-19 Vaccine

Doctor with blue gloves gives vaccine shot to shoulder of a woman

Researchers at Brigham and Women’s Hospital found that among patients with rheumatoid arthritis (RA), patient-reported disease activity stayed stable around the time of an additional COVID-19 vaccination dose when disease-modifying anti-rheumatic drugs (DMARDs) were held.

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COVIDprotocols.org: A New Approach to Developing Clinical Guidelines During a Crisis

COVIDprotocols.org, the world’s first and most comprehensive searchable website for step-by-step COVID-19 clinical guidelines, has its roots at the Brigham. Managing editor Edy Yong Kim, MD, PhD, of the Division of Pulmonary Care and Critical Care Medicine, provides a behind-the-scenes look at this valuable resource.

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Interest in COVID-19 Vaccination High Among Patients With Systemic Rheumatic Disease

Doctor administers COVID-19 vaccine to patient

Daniel H. Solomon, MD, MPH, Sara K. Tedeschi, MD, MPH, and colleagues surveyed patients with systemic rheumatic disease (SRD) about their attitudes toward COVID-19 vaccination. They report high interest and a high trust in physician recommendations about vaccination.

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Comprehensive Geriatric Assessment Successfully Adapted to Telehealth

Patient uses a tablet for telehealth visit with doctor

The COVID-19 pandemic had prompted a 130-fold increase in telehealth visits by U.S. Medicare recipients. The Division of Aging at the Brigham was part of that surge, adapting the comprehensive geriatric assessment (CGA) to be suitable for telephone and video visits.

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Clinical Use of Powered Air-Purifying Respirators Jeopardizes Communication, Hearing

Doctor wears personal protective equipment with hood in hospital

Emily Moldoff, NP, Carleton Eduardo Corrales, MD, and Jennifer J. Shin, MD, and colleagues have documented that the noise generated by powered air-purifying respirators creates a substantial barrier to communication during clinical interactions.

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COVID-19–related Psychological Factors Can Interfere with Mother–Infant Bonding

Mother holds and looks down at newborn infant

In a nationwide online survey of pregnant and postpartum women, Cindy H. Liu, PhD, and Carmina Erdei, MD, of Brigham and Women’s Hospital, and colleagues determined that psychological factors related to COVID-19, particularly grief, pose unique hazards to mother–infant bonding.

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