Latest Clinical & Research News
COVID-19 News
Quoc-Dien Trinh, MD, MBA, of the Department of Urology, and colleagues found that the usage of telehealth varied by surgical specialty during the COVD-19 pandemic, and their findings support previous data on socioeconomic disparities in telemedicine uptake.
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Jeffrey Sparks, MD, MMSc, and colleagues recently completed the first study of risk factors for repeat COVID-19 in an immunocompromised population. They report that use of rituximab, use of methotrexate, and younger age increased the risk of repeat COVID-19 among patients with systemic autoimmune rheumatic diseases.
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In a new study, a Brigham team determined how nasal foralumab modulates inflammation and describes a potential novel avenue for treating not just COVID-19 but also autoimmune diseases.
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A Mass General Brigham study suggests nirmatrelvir plus ritonavir (Paxlovid) reduces COVID-19 severity even in highly vaccinated adults over the age of 50. In this Q&A, Scott Dryden-Peterson, MD, MSc, and Ann Woolley, MD, MPH, discuss key takeaways from the study and describe best methods for prescribing Paxlovid.
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The “glycemic gap” has previously been validated as a predictor of severe acute illness. Now, Brigham and Women’s Hospital researchers have extended the glycemic index’s utility to COVID-19.
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Delays in stroke treatment were inevitable during the early months of the COVID-19 epidemic, given virus-related precautions and the massive influx of COVID-19 patients into hospitals. Understanding the precise extent of those delays is important to learn what factors lead to late care.
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In COVID-PACT, a 2×2 factorial, randomized, controlled trial that enrolled critically ill patients with COVID-19, researchers at Brigham and Women’s Hospital determined full-dose anticoagulation was superior to standard-dose prophylaxis in reducing the proportion of patients experiencing a thrombotic event.
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Researchers at Brigham and Women’s Hospital analyzed whole-metagenome shotgun (WMS) sequencing data by reconstructing microbial population genomes directly from microbiome samples of COVID-19 patients and controls. They report the creation of the first high-quality COVID-19–related genome catalog of the gut microbiome.
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Researchers at Brigham and Women’s Hospital recently completed the first large multicenter study of the incidence of ST-segment–elevation myocardial infarction (STEMI) as a complication of COVID-19. STEMI was rare in 0.35% of patients but was associated with poor in-hospital outcomes and high mortality.
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The need for advance care planning (ACP) was especially heightened for older, Black, and Latino/a/x patients at the onset of the COVID-19 pandemic. Brigham researchers tested an ACP intervention with video decision aids and remote clinician training, reporting improved ACP documentation rapidly and efficiently.
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