Johanna Seitz-Holland, MD, instructor in the Department of Psychiatry at Brigham and Women’s Hospital, and colleagues report that the senescence-associated secretory phenotype (SASP) index of 22 proteins suggests people with late-life depression are vulnerable to accelerated physical and cognitive decline.

Because of the size, shape, and location of the choroid plexus (ChP), it’s difficult to use automated MRI to determine its volume. Brigham and Women’s Hospital researchers developed the first MRI manual segmentation method for investigating ChP, and they observed significant ChP enlargement in early-course psychosis.

Researchers at Brigham and Women’s Hospital recently addressed neuroimaging research limitations. By coupling morphometric and brain lesion datasets with a “wiring” diagram of the brain, they derived a common brain network for psychiatric illness that is sensitive, specific, and robust.

Researchers at Brigham and Women’s Hospital have related acute neuroinflammatory response and changes in white matter structure after electroconvulsive therapy to each other and treatment outcomes.

To examine the value of large-scale collaboration, researchers at Brigham and Women’s Hospital and colleagues worldwide recently determined core predictors of functional outcome in bipolar disorder, independent of treatment organization or societal differences.