Latest Clinical & Research News
Specialty: Rheumatology
Brigham researchers recently completed the first proteomic analysis in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD). They identify molecular signatures strongly associated with the presence and severity of RA-ILD and provide insight into unexplored disease pathways.
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In the first study of its kind, Brigham and Women’s Hospital researchers showed that individuals with rheumatic conditions residing in neighborhoods with high social or heat vulnerability have greater odds of recurrent hospitalization than those with lower vulnerability.
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Researchers at Brigham and Women’s Hospital identified three distinct groups of gout patients according to their patterns of total spending on health care. The team provides information on identifying patients with gout who could benefit from interventions to reduce long-term spending.
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Calcium pyrophosphate deposition (CPPD) disease affects 8-10 million adults in the U.S., yet knowledge of CPPD lags far behind that of gout and other types of inflammatory arthritis. The Brigham’s Sara Tedeschi, MD, MPH, and the research team are working to understand the disease better and improve patient care.
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Researchers at Brigham and Women’s Hospital found that among patients with rheumatoid arthritis (RA), patient-reported disease activity stayed stable around the time of an additional COVID-19 vaccination dose when disease-modifying anti-rheumatic drugs (DMARDs) were held.
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In the first randomized, controlled trial to investigate if supplementation with vitamin D and/or Omega 3 fatty acids reduces the risk of autoimmune disease, Brigham researchers report that Omega 3 fatty acids alone did not reduce risk, but vitamin D or a combination of vitamin D and Omega 3 fatty acids was protective.
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There is growing evidence that rheumatoid arthritis (RA) originates in mucosal surfaces and several respiratory tract diseases are associated with RA. Now, researchers have demonstrated that the timing of respiratory tract disease significantly affects the strength of each disease’s association with RA.
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Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.
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Tracy J. Doyle, MD, Jeffrey A. Sparks, MD, MMSc, and colleagues identified a high prevalence of undiagnosed preclinical parenchymal lung disease in a rheumatoid arthritis cohort, with important clinical implications.
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Immune checkpoint inhibitor (ICI) therapies have revolutionized the treatment of advanced cancers, but they have a downside. Rheumatologist Deepak A. Rao, MD, PhD, is part of a study examining the rheumatologic manifestation of checkpoint inhibitor-associated arthritis in patients treated with a specific ICI therapy.
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