Latest Clinical & Research News
Specialty: Rheumatology
Brigham rheumatologist and Lupus Program director Karen Costenbader, MD, MPH, helped develop a risk prediction model for systemic lupus erythematosus (SLE) incorporating genetic, environmental, and lifestyle risk factors, as well as family history. Clinicians one day may use the model to predict individuals’ SLE risks.
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Hydroxychloroquine and chloroquine (HCQ/CQ) have known cardiovascular adverse effects. However, Brigham and Women’s Hospital researchers found that before the COVID-19 pandemic, electrocardiograms were infrequently obtained prior to initiation of HCQ/CQ and even less often during follow-up.
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Researchers at Brigham and Women’s Hospital conducted the first randomized, active comparator trial to explore the effect of disease-modifying anti-rheumatic drugs on vascular inflammation in rheumatoid arthritis.
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Mass General Brigham clinicians and colleagues showed polarization-sensitive optical coherence tomography (PS-OCT) can be performed minimally invasively and report results from a pilot study that will inform a large clinical trial to determine whether PS-OCT can predict the development of osteoarthritis.
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Members of the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital presented over 120 lectures and poster presentations at the 2022 American College of Rheumatology’s annual convergence conference. Learn more about a few of their cutting-edge presentations.
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Brigham researchers recently completed the first proteomic analysis in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD). They identify molecular signatures strongly associated with the presence and severity of RA-ILD and provide insight into unexplored disease pathways.
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In the first study of its kind, Brigham and Women’s Hospital researchers showed that individuals with rheumatic conditions residing in neighborhoods with high social or heat vulnerability have greater odds of recurrent hospitalization than those with lower vulnerability.
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Researchers at Brigham and Women’s Hospital identified three distinct groups of gout patients according to their patterns of total spending on health care. The team provides information on identifying patients with gout who could benefit from interventions to reduce long-term spending.
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Calcium pyrophosphate deposition (CPPD) disease affects 8-10 million adults in the U.S., yet knowledge of CPPD lags far behind that of gout and other types of inflammatory arthritis. The Brigham’s Sara Tedeschi, MD, MPH, and the research team are working to understand the disease better and improve patient care.
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Researchers at Brigham and Women’s Hospital found that among patients with rheumatoid arthritis (RA), patient-reported disease activity stayed stable around the time of an additional COVID-19 vaccination dose when disease-modifying anti-rheumatic drugs (DMARDs) were held.
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