Latest Clinical & Research News
Specialty: Rheumatology
Axial spondyloarthritis (axSpA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD). Anti-TNF agents are often used to treat concomitant axSpA and IBD. Brigham researchers have presented evidence that TNF inhibitors are less effective for axSpA than for IBD within one year.
Read More...Brigham scientists developed a method to simultaneously detect more than 2,000 CD1 lipid molecules that are displayed to T cells in the human immune system. This resulted in the first integrated CD1 lipidomic map, guiding the investigation of lipid T cell antigens and cleft blockers in any cellular system or disease.
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Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.
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Brigham orthopedist Christian Lattermann, MD, was the principal investigator of a study examining a possible connection between dysregulated inflammatory response and effusion synovitis after an ACL injury. He says risk stratification may help clinicians determine the appropriate treatment approach for each patient.
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In an observational study in “real-world” practice, Brigham and Women’s Hospital researchers did not identify significant differences in antibody response to COVID-19 vaccination among rheumatoid arthritis patients who held versus continued disease-modifying anti-rheumatic drugs for the last dose of the primary series.
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Michael E. Weinblatt, MD, and colleagues are conducting the first randomized, placebo-controlled study using an immunomodulator with pegloticase to increase urate-lowering response durability. Initial findings confirm the superiority of pegloticase plus methotrexate co-therapy to pegloticase monotherapy.
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Brigham rheumatologist and Lupus Program director Karen Costenbader, MD, MPH, helped develop a risk prediction model for systemic lupus erythematosus (SLE) incorporating genetic, environmental, and lifestyle risk factors, as well as family history. Clinicians one day may use the model to predict individuals’ SLE risks.
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Hydroxychloroquine and chloroquine (HCQ/CQ) have known cardiovascular adverse effects. However, Brigham and Women’s Hospital researchers found that before the COVID-19 pandemic, electrocardiograms were infrequently obtained prior to initiation of HCQ/CQ and even less often during follow-up.
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Researchers at Brigham and Women’s Hospital conducted the first randomized, active comparator trial to explore the effect of disease-modifying anti-rheumatic drugs on vascular inflammation in rheumatoid arthritis.
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Mass General Brigham clinicians and colleagues showed polarization-sensitive optical coherence tomography (PS-OCT) can be performed minimally invasively and report results from a pilot study that will inform a large clinical trial to determine whether PS-OCT can predict the development of osteoarthritis.
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