Mouse PLPP6 Regulates Allergen Sensitization
![Dendritic cell, antigen-presenting immune cell, 3D illustration](https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg)
Brigham and Women’s Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a polyisoprenyl diphosphate phosphatase that’s activated in dendritic cells after airway exposure to an aeroallergen. They suggest PLPP6 is likely a targetable regulatory checkpoint for allergic inflammation.
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