Brain Lesions Associated With Addiction Remission Map to a Common Circuit

3D rendering of human head with brain activity colored fibers

It’s possible to link lesions in different brain locations to a common neuroanatomical substrate using the human connectome. Using this approach, Brigham researchers have identified specific testable targets for therapeutic neuromodulation of nicotine addiction.

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No Association Detected Between Cystic Lesions of the Pineal or Pituitary Gland

3D pink glowing outline of human brain with pineal gland highlighted

Because of imaging advances, incidental diagnosis of midline intracranial neuroendocrine cystic masses is increasingly common. Edward Laws, MD, of the Pituitary and Neuroendocrine Program at Brigham and Women’s Hospital, and colleagues examined whether there’s a link between Rathke cleft cysts and pineal gland cysts.

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Telemedicine Extends Brigham’s Rich History of Neurosurgical Innovation to Underserved Areas

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Advances in telemedicine are enabling the Brigham to bring high-quality neurosurgical care to patients nationally and internationally. Timothy R. Smith, MD, PhD, MPH, of the Department of Neurosurgery, discusses how these efforts reflect the broader movement to meet patients’ right to healthcare globally.

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Could an Intranasal Vaccine Transform Alzheimer’s Prevention and Treatment?

Diagram of Alzheimer's disease with amyloid plaques, neurofilbrillary tangles, and neuronal loss

A groundbreaking intranasal vaccine for Alzheimer’s disease (AD) developed at Brigham shows tremendous promise in its first phase of human trials. Study leader Howard L. Weiner, MD, discusses the trial’s progress to date, planned future phases, and how the vaccine could shape the future of AD care.

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Progressive Parental Leave Policy in the Mass General Brigham Neurology Residency

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Mass General Brigham Neurology Residency leaders recently revised its parental leave policy to better embody equity, fairness, transparency, and wellness values. They discuss the impact of the updated policy and offer suggestions for other programs that wish to implement a parental leave policy with similar goals.

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Glioblastoma: Creating a Viral Oasis in an Immune Desert

Dana-Farber Brigham Cancer Center is world-renowned for its commitment to cutting-edge research. Over the years, its researchers have turned scientific discoveries into life-saving treatments, contributing to the development of 35 of 75 cancer drugs recently approved by the FDA for use in cancer patients. Read More

New Tool Allows Early Prediction of Disease Course in Multiple Sclerosis

Rendering of orange microglia cells damaging the myelin sheath of neuron axons

Using machine learning, researchers in the Brigham Multiple Sclerosis Center and colleagues have developed a tool for predicting what the outcome of patients with recently diagnosed MS will be in 10 years.

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Adults With TBI May Benefit From Screening for Cardiometabolic Disease, Other Comorbidities

Female doctor shows brain scan images to older male patient in hospital bed

An analysis of prospectively collected data has demonstrated that adults who sustain traumatic brain injury (TBI), regardless of age and injury severity, are at higher risk of certain cardiovascular, endocrine, neurologic, and psychiatric disorders.

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Review: Targeting Oncometabolism to Maximize Immunotherapy in Brain Cancer

Cells stained with different colors in a false color image of a tumour sample

Joshua D. Bernstock, MD, PhD, in the Department of Neurosurgery at Brigham and Women’s Hospital, Gregory K. Friedman, MD, of the University of Alabama at Birmingham, and colleagues reviewed novel therapies that target oncometabolism and tumor immunometabolism.

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Traumatic Brain Injury: a Chronic Disease That Affects More Than the Brain

Scientists and clinicians are starting to recognize links between traumatic brain injury and comorbidities such as cardiometabolic disease. Brigham associate neurologist Saef Izzy, MD, MBChB, discusses what he has observed in studying these links as well as possible implications for clinical care.

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