Nasal Monoclonal Antibody Suppresses Inflammatory Response in COVID-19

In a new study, a Brigham team determined how nasal foralumab modulates inflammation and describes a potential novel avenue for treating not just COVID-19 but also autoimmune diseases.


Review: Myelin Oligodendrocyte Glycoprotein Antibody Disease

Various demyelinating diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis (ADEM), and cerebral cortical encephalitis, are now recognized as a spectrum of diseases associated with high titers of autoantibodies that target myelin oligodendrocyte glycoprotein (MOG).


Economic Burden of Neuromyelitis Optica Spectrum Disorders Quantified From Patient Point of View

Brigham and Women’s Hospital researchers recently conducted the first study of patient-reported data on the economic burden of neuromyelitis optica spectrum disorders (NMOSD). Specifically, they characterized the direct and indirect costs of relapse events (ED visits and hospitalizations).


Variants of AAV9 Efficiently Cross the Blood–Brain Barrier in Non-Human Primates

Researchers at Brigham and Women’s Hospital have designed two promising AAV9 variants that are much more effective than the parent vector for delivering therapeutic transgenes into the central nervous system of mice and macaques.


People Have “Massive” Memory for Where and When They Saw Something

Researchers at Brigham and Women’s Hospital have shown more specifically that humans have a spatial massive memory—they can remember where they saw objects presented briefly—and a temporal massive memory—they can remember when they saw the objects.


Delirium Superimposed on Dementia During Hospitalization Has Complex Effect on Costs

senior male patient with IV

Tammy T. Hshieh, MD, MPH, and colleagues recently explored from a healthcare system perspective the direct costs of delirium in hospitalized patients with and without Alzheimer’s disease or a related disorder.


Somatic Variants in Supervillin Increase Susceptibility to Cerebral Aneurysms

Human brain 2d digital illustration

Researchers at Brigham and Women’s Hospital recently reported that somatic variants—specifically, in the supervillin (SVIL) gene—increase susceptibility to intracranial aneurysms through changes in vascular smooth muscle cells (vSMCs).


AAN 2023: Brigham Neurologists Present Latest Research

3d rendering of a brain

On April 22–27, 2023, the American Academy of Neurology hosts its 75th annual meeting in Boston, MA and virtually. Leaders from the Department of Neurology at Brigham and Women’s Hospital will present their latest research at the meeting alongside international colleagues.


Brigham Neurosurgery at the AANS 2023 Annual Scientific Meeting

Neurosurgeon in special surgery glasses performing operation

Experts from the Department of Neurosurgery at Brigham and Women’s Hospital join other neurosurgical leaders at this year’s AANS Annual Scientific Meeting, “Neurosurgeons as Advocates,” held April 21 – 24, 2023, in Los Angeles, CA.


Anterior Temporal Lobectomy Has Clear Utility in Medically Refractory Herpes Simplex Virus Encephalitis

Herpes simplex virus (HSV) is the most common cause of viral encephalitis. The brain lesions in HSV encephalitis (HSVE) primarily involve the temporal and frontal lobes. About half of patients develop seizures, which may progress to chronic seizure disorders or status epilepticus.