Exploring the Role of Neurons in the Tumor Microenvironment that Drive Cancer Growth

Humsa Venkatesh, PhD, a cancer biologist, is studying the neural regulation of cancer and how nervous system cells found within the tumor microenvironment drive tumor growth. Her research has implications for primary brain tumors such as gliomas and for tumors that metastasize to the brain from other parts of the body.

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WEB Embolization: Transradial and Transfemoral Access Are Comparably Safe, Effective

CT Scan Axial View of Brain to Detect Aneurysm

Mahmoud Dibas, MD, and Adam A. Dmytriw, MD, MPH, MSc, at Brigham and Women’s Hospital, and colleagues used data from a large multicenter study to compare transradial access with transfemoral access for WEB embolization. They report the two approaches were associated with comparable radiologic and clinical outcomes.

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Cranial Nerve Imaging Abnormalities in Patients With Hereditary Neuropathies Can Mimic Otolaryngologic Problems

Doctor points to brain scan images to detect abnormalities

C. Eduardo Corrales, MD, Ryan A. Bartholomew, MD, and colleagues detected a 21% prevalence of radiologic cranial nerves abnormalities in patients with hereditary neuropathies who underwent MRI. They caution physicians not to assume these findings represent pathologies requiring intervention by an otolaryngologist.

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Novel Transcranial Doppler Screening Approach Identifies Risk of Radiological Delayed Cerebral Ischemia

Transcranial Doppler examination searching for vasospasm after subarachnoid hemorrhage

Samuel B. Snider, MD, Ibrahim Migdady, MBBS, Rose Du, MD, PhD, of Brigham and Women’s Hospital, and colleagues found the severity of transcranial doppler screening-measured vasospasm predicts radiological delayed cerebral ischemia in a vessel-specific manner.

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Brigham Neurosurgery Leads Revival in the Use of Ultrasound for Brain Tumor Resection

Dr. Golby and Team Using Ultrasound in Operating Room

Intraoperative magnetic resonance imaging is an extremely useful tool in guiding surgical brain tumor resection but also has significant drawbacks. The Brigham’s Department of Neurosurgery is turning to an older alternative: ultrasound. Alexandra J. Golby, MD, director of image-guided neurosurgery, explains.

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Brain Circuit Mapping Refines Targets for Neurostimulation

Researchers at Brigham and Women’s Hospital have developed a novel brain mapping method that suggests lesions, TMS and DBS converge on a common brain circuit for depression—which may represent a better target for therapeutic neurostimulation. The approach seems to be generalizable to other neuropsychiatric diseases.

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Stem Cell-derived Neurons Facilitate Study of Alzheimer’s Disease Mechanisms, Treatments

3D rendering of pluripotent stem cells

Tracy Young-Pearse, PhD, Valentina Lagomarsino, Richard V. Pearse II, PhD, and colleagues have created a system that fills the gap between autopsy studies and genetic studies. They’ve shown that neurons derived from induced pluripotent stem cells (iPSCs) reflect molecular mechanisms underlying late-onset AD.

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“Self-tunable” Engineered Yeast Probiotics May Allow Precision Treatment of IBD

Francisco J. Quintana, PhD, Cristina Gutiérrez-Vázquez, PhD, and colleagues engineered yeasts that generate an immunosuppressive molecule in direct proportion to the amount of a pro-inflammatory metabolite produced in the inflamed gut. They describe their new treatment platform and the results.

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What Are the Best Treatment Options for Epilepsy That Doesn’t Respond to Medications?

3-D segmented coronal MRI demonstrating bilateral deep brain stimulation.

Physicians at the Brigham are developing various treatments to improve seizure control for patients with epilepsy. As Garth Rees Cosgrove, MD, director of epilepsy and functional neurosurgery, explains, these therapies require a great deal of diagnostic and surgical expertise along with the latest cutting-edge tools.

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Case Series: MRI-guided Focused Ultrasound Thalamotomy

David J. Segar, MD, and G. Rees Cosgrove, MD, at Brigham and Women’s Hospital, and colleagues have reported the largest single-surgeon series of focused ultrasound thalamotomy to date. They demonstrate tremor relief and adverse event rates consistent with previous reports and present new information about predictors…

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