Latest Clinical & Research News
Specialty: Infectious Disease
Building on previous findings, Brigham and Women’s Hospital researchers report that the immunity imbalance predisposing to herpes simplex virus-2 (HSV-2) isn’t limited to the cervix but rather extends to the systemic circulation. HSV-2 may alter both mucosal and peripheral innate immunity to contribute to HIV-1 risk.
Read More...
The “glycemic gap” has previously been validated as a predictor of severe acute illness. Now, Brigham and Women’s Hospital researchers have extended the glycemic index’s utility to COVID-19.
Read More...
Delays in stroke treatment were inevitable during the early months of the COVID-19 epidemic, given virus-related precautions and the massive influx of COVID-19 patients into hospitals. Understanding the precise extent of those delays is important to learn what factors lead to late care.
Read More...
Brigham researchers believe a new host-directed treatment approach to secondary bacterial pneumonia, a serious and common complication of infection with the influenza A virus (IAV) that can also occur after SARS-CoV-2 infection, might complement antibiotic therapy.
Read More...
In COVID-PACT, a 2×2 factorial, randomized, controlled trial that enrolled critically ill patients with COVID-19, researchers at Brigham and Women’s Hospital determined full-dose anticoagulation was superior to standard-dose prophylaxis in reducing the proportion of patients experiencing a thrombotic event.
Read More...
Researchers at Brigham and Women’s Hospital analyzed whole-metagenome shotgun (WMS) sequencing data by reconstructing microbial population genomes directly from microbiome samples of COVID-19 patients and controls. They report the creation of the first high-quality COVID-19–related genome catalog of the gut microbiome.
Read More...
Researchers at Brigham and Women’s Hospital recently completed the first large multicenter study of the incidence of ST-segment–elevation myocardial infarction (STEMI) as a complication of COVID-19. STEMI was rare in 0.35% of patients but was associated with poor in-hospital outcomes and high mortality.
Read More...
Raina N. Fichorova, MD, PhD, and Hidemi S. Yamamoto, BA, of the Laboratory of Genital Tract Biology in the Department of Obstetrics and Gynecology at the Brigham, and colleagues have discovered concurrent exposure to Trichomonas vaginalis and bacterial vaginosis dysregulates the expression of galectins.
Read More...
Daniel H. Solomon, MD, MPH, Sara K. Tedeschi, MD, MPH, and colleagues surveyed patients with systemic rheumatic disease (SRD) about their attitudes toward COVID-19 vaccination. They report high interest and a high trust in physician recommendations about vaccination.
Read More...“Who knew that rheumatology patients would be right in the middle of the COVID-19 crisis?”
This question was posed by rheumatologist Karen H. Costenbader, MD, MPH, director of the Brigham and Women’s Hospital Lupus Program and chair of the Medical and Scientific Advisory Council for the Lupus Foundation of America. In these roles, she has found herself at the center of the controversy around the use of hydroxychloroquine (HCQ) and other rheumatology medications in COVID-19. Read More