Vitamin D With or Without Omega 3 Fatty Acids Reduces Risk of Autoimmune Disease

Brown bottle of vitamin D and fish oil capsules spilling onto wooden surface

In the first randomized, controlled trial to investigate whether supplementation with vitamin D and/or fatty acids can reduce the risk of autoimmune disease, Brigham researchers report that fatty acids alone did not reduce risk, but vitamin D or a combination of vitamin D and fatty acids was protective.


Making Headway in Targeting Glioblastoma Multiforme

Brain MRI showing a needle inserted into a glioblastoma multiforme tumor highlighted in purple

Break Through Cancer is a foundation that brings together elite cancer research centers to collaborate on and accelerate research, clinical trials and cures for deadly cancers, including glioblastoma multiforme. The Brigham’s Nathalie Y. R. Agar, PhD, and E. Antonio Chiocca, MD, PhD, discuss this ambitious undertaking.


Leveling the Playing Field: The Importance of Graft Choice for ACL Reconstruction in Female Athletes

Graft for ACL Reconstruction

The Women’s Sports Medicine Program at the Brigham aims to narrow the disparity in outcomes between female and male athletes following anterior cruciate ligament injury. Program Chief Elizabeth G. Matzkin, MD, explains how determining the optimal graft size and source for surgical reconstruction can improve outcomes.


Complexity of the Geriatric Patient: Q&A With Dr. Houman Javedan

Close up of older patient holding cane and being helped by medical professional

In an effort to clearly define the role of a geriatrician and establish best practices for the treatment of geriatric patients, Houman Javedan, MD, clinical director for the Division of Aging, developed a Geriatrics Clinical Reasoning curriculum that has completely transformed geriatric care at the Brigham.


Complication Rates High When New Surgeons Treat Spinal Deformity

Close up of doctor holding an x-ray of the spine

Studies have established a relationship between surgeon volume and patient outcomes in spine surgery. Given the additional complexity of spinal deformity surgery, younger surgeons may be particularly disadvantaged. Caleb Yeung, MD, Melvin Makhni, MD, MBA, and colleagues conducted the first study on this question.


Reprogramming of Smooth Muscle Cells May Facilitate Blood Vessel Repair

Microscopic image of human heart muscle

Researchers at Brigham and Women’s Hospital have published a proof-of-principle study showing vascular smooth muscle cells themselves can be transformed into endothelial cells.


Plication Transoral Outlet Reduction Safely Treats Weight Regain After Gastric Bypass

Close up measuring waist with measuring tape

Endoscopists at Brigham and Women’s Hospital have conducted the first study in which plication endoscopic transoral gastric outlet reduction was combined with argon plasma coagulation to treat weight gain after Roux-en-Y gastric bypass.


Five Distinct Clusters of Patients With Laryngeal Symptoms Identified

Man holding chest with red highlight to indicate discomfort from reflux symptoms

In the first study of its kind, Walter W. Chan, MD, PhD, at Brigham and Women’s Hospital, and colleagues identified “clusters” of patients with laryngeal symptoms who were evaluated for reflux.


Sensitive Cognitive Outcomes Preclinical Alzheimer’s Disease Trials

3D rendering of Beta-amyloid found in Alzheimer's disease.

Kathryn V. Papp, PhD, and Reisa A. Sperling, MD, at Brigham and Women’s Hospital, and colleagues recently determined that very early Alzheimer’s disease is associated with a decline in existing measures of processing speed and memory retrieval.


Black Elders Show Greater Posttraumatic Growth During COVID-19 Than White Elders

Black older man sitting at edge of bed wearing COVID-19 mask

Patrizia Vannini, PhD, of the Department of Neurology, and colleagues conducted the first study of posttraumatic growth and other mental health factors related to COVID-19 among older adults. They describe how the pandemic affected Black and white older adults differently and name ways to foster posttraumatic growth.