Biodegradable Implantable Device Developed for Intravesical Therapy of Bladder Disorders

3D rendering of human bladder anatomy highlighted orange

Implantable devices for drug delivery to the bladder require surgical implantation and removal. Scientists at Brigham and Women’s Hospital have invented a biodegradable ring-shaped implantable device (BRID) for long-term and local drug delivery inside the bladder that does not require a retrieval procedure.

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Brigham Researchers Develop Efficient Method to Generate Ureteric Bud, First Human Functional Collecting Duct Principal and Intercalated Cells

Doctor holds anatomical model of a human kidney, pointing to it while seated at desk

Creating kidney organoids for preclinical research poses a challenge due to their complex architecture. Brigham researchers have developed an efficient method for generating functional ureteric bud and collecting ducts organoids, which drive the growth and radial organization of the developing kidney.

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CRP-to-Albumin Ratio Reflects Risk of Adverse Events After Spinal Epidural Abscess Treatment

MRI of cervical spine showing epidural abscess that causes spinal cord compression and paralysis

Matthew H. Lindsey, MD, Andrew J. Schoenfeld, MD, MSc, of the Department of Orthopaedic Surgery at Brigham and Women’s Hospital, and colleagues have published putative evidence that the C-reactive protein to albumin ratio can help predict adverse events after spinal epidural abscess treatment.

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Newly Identified Role of α-Synuclein May Lead to Novel Parkinson’s Disease Therapy

3d illustration of nerve cell with abnormal protein accumulations, lewy bodies

Vikram Khurana, MD, PhD, and colleagues have discovered an additional function of α-Synuclein—it modulates the stability of mRNA, thereby regulating gene expression. They explain the implications for understanding normal cellular physiology and developing therapies for Parkinson’s disease and related disorders.

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Addressing the FINER Points of Chronic Pain Management

Young woman sitting at desk in bright room uncomfortable from lower back pain

Brigham physiatrist Danielle L. Sarno, MD, is committed to reducing chronic pain among patient populations by increasing access to interdisciplinary pain care and linking patients to pain management resources. She and Jennifer Kurz, MD, established a program to help people find long-term solutions for chronic pain.

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Brain-derived Neurotrophic Factor Linked to Improved Cognitive Performance in Older Adults

Brain-derived neurotrophic factor protein molecule. Cartoon representation with gradient coloring

Kirk R. Daffner, MD, and colleagues found five weeks of cognitively stimulating activity by healthy older adults increased brain-derived neurotrophic factor (BDNF) levels and cognitive performance. They report evidence that the improvement in cognition with training was mediated by increases in BDNF.

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Cost of Anterior Cervical Decompression and Fusion Are Highly Variable in Healthcare Systems

Lateral projection cervical spine x-ray showing anterior cervical discectomy and fusion or ACDF procedure.

Hospital costs associated with anterior cervical decompression and fusion (ACDF) are highly heterogeneous. Andrew K. Simpson, MD, MBA, MHS, the Department of Orthopaedic Surgery at Brigham and Women’s Hospital, and colleagues conducted the first rigorous analysis of the relative drivers of ACDF costs.

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Brigham Cardiovascular Experts Attend AHA Scientific Sessions 2022

Audience seated looking up at male presenter at a conference

On November 5—7, 2022, experts from the Brigham’s Heart and Vascular Center will join thousands of colleagues in raising awareness and improving cardiovascular health at this year’s American Heart Association (AHA) Scientific Sessions.

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Neighborhood Vulnerability to Heat Affects Risk of Recurrent Hospitalization in Individuals With Rheumatic Conditions

Young man standing under hot bright sun and clear sky, wiping sweat from forehead

In the first study of its kind, Brigham and Women’s Hospital researchers showed that individuals with rheumatic conditions residing in neighborhoods with high social or heat vulnerability have greater odds of recurrent hospitalization than those with lower vulnerability.

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Transoral Incisionless Fundoplication Cost-Effective for Treatment of GERD

Blue outline of human anatomy showing GERD highlighted red, acid reflux in stomach

Thomas R. McCarty, MD, MPH, Christopher C. Thompson, MD, and colleagues recently constructed a computer model to evaluate the cost-effectiveness of various strategies for treating gastroesophageal reflux disease (GERD) that is refractory to standard-dose proton pump inhibitor (PPI) therapy.

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