Pain and Impaired Function Soon After ACL Reconstruction Predict Altered Knee Mechanics at Six Months

Patient knee in surgery, surgeons preparing tendon for ACL reconstruction

Christian Lattermann, MD, Mass General Brigham director of Sports Medicine Research, Alexa K. Johnson, PhD, and colleagues recently conducted a pilot study of what factors contribute to altered loading after ACL reconstruction.


Review: Cerebrovascular Injuries in Traumatic Brain Injury

Traumatic cerebrovascular injury (TCVI)—blunt or penetrating injury to the carotid arteries, vertebral arteries, venous structures or a combination—can be a serious sequela of traumatic brain injury. TCVI may be obscured by nearby neurological injury and go undetected for weeks or even years after the initial injury.


Benefits of Electronic Health Records in the Management of Hypogonadal Men

Doctor working on laptop computer and medical stethoscope on clipboard on desk, EHR concept

Electronic health records (EHRs) have multiple benefits for both clinicians and patients, but can lead to clinician burnout. Martin Kathrins, MD, and Anna Goldman, MD, of Brigham and Women’s Hospital, discuss how EHRs can optimize the treatment of hypogonadal men.


Brigham Orthopaedics Present at AAOS 2023

3D illustration of human body with joints highlighted red, orthopedics concept

From March 7 – 11, leaders from the Department of Orthopaedic Surgery at Brigham and Women’s Hospital will present their latest advancements at the 2023 American Academy of Orthopaedic Surgeons Annual Meeting in Las Vegas, Nevada.


Multisystems Approach Identifies Environmental Chemicals That Promote Intestinal Inflammation

Researchers at Brigham and Women’s Hospital are using an integrated systems approach—a publicly available database, zebrafish chemical screens, machine learning and mouse models—to identify environmental chemicals that promote intestinal inflammation.


ACC 2023: Brigham Heart & Vascular Leaders Present Latest Research

Blue 3D illustration of holographic human heart in virtual reality

Cardiovascular experts from Brigham and Women’s Hospital will present their latest research and clinical advancements at this year’s American College of Cardiology Scientific Session & Expo on March 4 – 6, 2023, held virtually and in-person in New Orleans, LA.


Geographic Disparities Demonstrated in Outcomes After Orthopedic Trauma Surgery

Close up of person using crutches to walk with brace on ankle and leg, broken leg concept

It’s been established that unequal distribution of physicians contributes to overall healthcare disparities between urban and rural communities. Now, Brigham and Women’s Hospital researchers have demonstrated the same is true for orthopedic trauma outcomes.


ECG Testing Infrequent for Patients Receiving Hydroxychloroquine or Chloroquine

Woman holding glass of water and taking white pill, hydroxychloroquine medication concept

Hydroxychloroquine and chloroquine (HCQ/CQ) have known cardiovascular adverse effects. However, Brigham and Women’s Hospital researchers found that before the COVID-19 pandemic, electrocardiograms were infrequently obtained prior to initiation of HCQ/CQ and even less often during follow-up.


LSD1 Modifies Aldosterone Synthesis in a Sex-specific Manner

3d rendered medical illustration of a woman's adrenal glands highlighted orange

Brigham researchers reinforce previous studies showing LSD1 heterozygote knockout mice displayed altered aldosterone secretion/MR activation in an age- and sex-dependent manner, and for the first time, they report that even at the level of aldosterone biosynthesis, there is an effect of biological sex.


Tricortical Skull Anatomy Is a Potential Contraindication for MR-guided Focused Ultrasound

The human thalamus

Joshua D. Bernstock, MD, PhD, G. Rees Cosgrove, MD, and colleagues described unsuccessful thalamotomy in a patient who displayed hyperostosis calvariae diffusa—expansion of the frontal endocranium in addition to the bones within the skull—as well as tricortical osseous anatomy.