Low-Dose Interleukin 2 Shows Promise for Treatment of Ulcerative Colitis

Human interleukin-2 in complex with interleukin-2 receptor

Researchers at Brigham and Women’s Hospital recently published data from an open-label phase 1b/2a trial suggesting induction therapy with low-dose IL-2 is safe for patients with ulcerative colitis and suppresses the disease.


Brigham Presents at Transcatheter Cardiovascular Therapeutics 2023

Cardiovascular experts from Brigham and Women’s Hospital will present at this year’s Transcatheter Cardiovascular Therapeutics (TCT) Conference on interventional cardiology, held October 23–26 in San Francisco, CA.


Multiomics Approach Implicates Tissue Extracellular Vesicles in Atherosclerosis and Calcific Aortic Valve Stenosis

Using a novel method, Brigham and Women’s Hospital researchers completed the first comparative proteomics study of pathogenesis in calcified carotid arteries and aortic valves (AVs), identifying unique drivers of atherosclerosis versus AV stenosis and implicating extracellular vesicles in both diseases.


Study Shows How MTAP Influences Response to Immunotherapy Drugs

Immunotherapy drugs that harness a patient’s immune system to fight cancer have become an important treatment for a subset of patients with certain cancers. A team co-led by investigators from Brigham and Women’s Hospital has uncovered new findings about why some patients fail to respond to these drugs. The research suggests new approaches for making the medications more effective. Read More

Discussion Over Treatment vs. Surveillance for Screen-Detected Prostate Cancer

In October, The New England Journal of Medicine published a case vignette focusing on a 61-year-old man with prostate cancer. Two physicians—Anthony Victor D’Amico, MD, PhD, chief of Genitourinary Radiation Oncology at Dana-Farber Brigham Cancer Center, and Freddie Hamdy, FRCS(Urol.), FMedSci, of the Nuffield Department of Surgical Sciences at the University of Oxford—present evidence on the appropriate clinical care approach. NEJM readers can cast their vote on which direction they would take based on the two essays. Read More

Tumor Treating Fields Reconceptualized As Targeted Implanted Therapy for Complex High-Grade Glioma

Researchers at Brigham and Women’s Hospital believe an implanted intracranial stimulation system could increase both the strength and duration of tumor treating fields (TTF) delivery.


Could Shared Decision Making Eliminate Racial and Ethnic Disparities in Prostate Cancer Screening?

The efficacy of prostate-specific antigen (PSA) screening in reducing prostate cancer (PCa) mortality remains a matter of debate. Nonetheless, some racial and ethnic minority groups—particularly Black and Hispanic men—are less likely to receive prostate cancer screening and treatment. This discrepancy, in turn, may contribute to racial and ethnic disparities in PCa outcomes, including higher mortality rates. Read More

Case Study: Endobronchial Valve Placement in a Patient With an Incomplete Lobar Fissure

CT scan of lungs before and after endobronchial valve placement

A team at the Brigham’s Lung Center performed a complex, two-step procedure to place endobronchial valves in a 59-year-old woman who had hyperinflation of her lungs due to advanced COPD, combined with an incomplete lobar fissure. Interventional pulmonologist Majid Shafiq, MD, MPH, discusses this challenging case.


Why Do Some Patients Respond Better to Immunotherapy Than Others?

Immune-checkpoint blockade (ICB) therapy has been a life-changing advance for a subset of people with cancer, but additional research is needed to learn how to make these treatments more broadly effective and longer lasting. A team led by scientists at Brigham and Women’s Hospital has published a paper revealing new details about the tumor characteristics that facilitate a strong clinical response to these drugs. Read More