Latest Clinical & Research News
Total knee replacement (TKR) for the treatment of advanced knee osteoarthritis is an efficacious and cost-effective treatment, even for people with extreme obesity (defined as having a body mass index, or BMI, of 40 or higher). This finding from experts at Brigham and Women’s Hospital was published recently in the Annals of Internal Medicine.
The disparity in pay between gynecologic surgery and other surgical specialties has been well-established. In a recent commentary, faculty from Brigham and Women’s Hospital and Northwestern University describe the history of this issue and other influences that drive what they call “double discrimination” — lower pay in an area of surgery that has the largest proportion of female surgeons and one that serves primarily female patients.
PARP inhibitors have become an important part of the arsenal for treating cancers caused by BRCA mutations — including breast cancer. Recently, clinical trials have begun looking at the combination of PARP inhibitors and immune checkpoint inhibitors in breast cancer, with the goal of making treatment more effective and longer lasting.
Despite the formidable challenges created by the novel coronavirus pandemic, the Brigham and Women’s Hospital General and Gastrointestinal Surgery and Gastroenterology, Hepatology and Endoscopy divisions celebrated substantial achievements in 2020.
Immunotherapy with checkpoint inhibitor drugs is an emerging treatment for renal cell carcinoma. Now investigators from Brigham and Women’s Hospital have reported the results from lab research looking at a potential new way to boost the immune system’s ability to fight cancer.
A retrospective study published by JAMA and conducted by researchers at Brigham and Women’s Hospital found that transferring fresh embryos grown from freshly retrieved donor eggs resulted in a higher live birth rate compared to frozen (cryopreserved and thawed) embryos from freshly retrieved donor eggs.
Brigham and Women’s Hospital’s Division of Endocrinology, Diabetes and Hypertension cares for patients with a wide range of hormonal and other related disorders, including diabetes, hypertension and thyroid disease. Division Chief Ursula B. Kaiser, MD, recently discussed some of her group’s accomplishments and how the COVID-19 pandemic has affected physicians and other health care providers in the division.
Timely diagnosis of an acute aortic dissection is the first key step to saving a patient’s life. However, not all hospitals are equipped to handle the next critical step: administering timely treatment to reestablish true lumen flow in the aorta. In these cases, according to an invited expert review published in The Annals of Thoracic Surgery, rapid transfer of the patient to a center of excellence is advisable.
Today’s cancer therapies are helping patients live longer. However, treatments including surgery, radiation, chemotherapy and certain targeted and immunological therapies increase the risk of developing cancer-associated thrombosis (CAT). Physicians at Brigham and Women’s Hospital’s Heart & Vascular Center are working with colleagues at Dana-Farber Cancer Institute (DFCI) to help prevent CAT and minimize its effect on timely cancer care.
Since the beginning of the COVID-19 pandemic, Walter W. Chan, MD, MPH, director of the Center for Gastrointestinal Motility at Brigham and Women’s Hospital, and colleagues in the Division of Gastroenterology, Hepatology and Endoscopy, have led several clinical studies investigating COVID-19 infection presentation, risk factors and outcomes on the gastrointestinal (GI) system.