Long-term Infliximab Does Not Contribute to Weight Gain in Patients With IBD

3D rendering of Tumor Necrosis Factor (TNF)-α Inhibitor molecule

Rachel W. Winter, MD, MPH, at Brigham and Women’s Hospital, and colleagues in Denmark conducted the largest study ever to evaluate weight change during TNF inhibitor therapy for patients with inflammatory bowel disease and report low weight gain overall with infliximab.


Blood Test Offers Better Prediction of Preeclampsia Risk

Researcher in lab setting selecting from upright plasma samples on table

Researchers have shown that a novel molecular signature from a single blood sample can identify women at risk of preeclampsia months before presentation. They also report that molecular signatures accurately track gestational age, independently of clinical factors, and could advance the study of other complications.


Presurgical Physical, Psychosocial and Sensory Factors All Influence Total Knee Arthroplasty Outcomes

Doctor evaluates patient knee suture scar after total knee arthroplasty

Robert R. Edwards, PhD, of the Center for Pain Management at Brigham and Women’s Hospital, and colleagues conducted the first multicenter study that comprehensively examined clinical, functional, psychosocial and sensory factors as predictors of pain and functional outcomes after total knee arthroplasty.


Respiratory Tract Diseases May Increase Risk of RA Years Before Onset

Close up of hands affected by rheumatoid arthritis

There is growing evidence that rheumatoid arthritis (RA) originates in mucosal surfaces and a range of respiratory tract diseases are associated with RA. Now, researchers have demonstrated that the timing of respiratory tract disease diagnosis significantly affects the strength of each disease’s association with RA.


New Treatment Strategy Proposed for Rheumatic Heart Valve Disease

Close up of valve replacement surgery where artificial valve is being implanted

Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.


Inside the NICU: When the Parent Becomes the Patient

Close up of doctor's hands holding a newborn in the NICU

The Brigham’s new multidisciplinary Parent Mental Health Program, created by Cindy H. Liu, PhD, and Leena P. Mittal, MD, is designed to provide timely and consistent mental health services for parents and caregivers of infants hospitalized in the neonatal intensive care unit.


Two-Way Communication Necessary to Re-engage Patients in Diabetes Care After Major Disruption

Close up of woman typing on phone with agenda book open on table

When the COVID-19 lockdown began, the Brigham’s Diabetes Management Program developed a protocol for reaching out to patients whose routine clinic visits were abruptly canceled. A study led by Marie E. McDonnell, MD, revealed two-way communication was necessary to re-engage patients in diabetes care after disruption.


Adjustable Intragastric Balloon Permits Individualized Weight Loss Therapy

3D rendering concept of a gastric balloon inside a stomach

In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.


Timing of High-grade PVCs During Stress Testing Stratifies Risk of Cardiovascular Mortality

Electrocardiogram revealing premature ventricular contractions

Brigham and Women’s Hospital researchers investigated the prognostic value of premature ventricular contractions (PVCs) in asymptomatic individuals not suspected of having heart disease. High-grade PVCs that occurred during recovery from stress testing were associated with long-term cardiovascular mortality.


Researchers Probe Links Between Colorectal Cancer, Bariatric Surgery and the Microbiota

Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.