Exploring How to Enhance Drug Delivery and Efficacy Through Nanoparticles and Macroscale Materials

Micrograph of a hydrogel, nanoparticle for gene delivery, and microneedle patch

Natalie Artzi, PhD, a principal investigator in the Brigham and Women’s Hospital Department of Medicine, has changed our basic understanding of biomaterials under different environmental and pathological states. Her lab is dedicated to designing smart biomaterial platforms and medical devices to improve human health.

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Million Veteran Program Affirms Advice to Limit Red Meat Intake

Using a very large U.S. prospective cohort from the Million Veteran Program, Brigham and Women’s Hospital researchers report that a higher intake of red meat, either processed or unprocessed, was associated with a higher risk of cardiovascular disease.

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Liposomal Bupivacaine Is Good Alternative to Thoracic Epidural Analgesia for Patients Undergoing Minimally Invasive Lung Resection

Namrata Patil, MD, MPH, Anupama Singh, MD, and team compared thoracic epidural analgesia with injection of liposomal bupivacaine (LB) under direct witness in patients undergoing minimally invasive lung resection. LB intercostal block reduced opioid use 48 hours postoperatively and had fewer postoperative complications.

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Implant Survival After TKA at Age 40 or Younger Is Comparable to Rates in Older Adults

Department of Orthopaedic Surgery researchers at Brigham and Women’s Hospital and colleagues recently completed a retrospective study of patients who underwent total knee arthroplasty (TKA) at age 40 or younger. They report that 15-year revision-free implant survival was comparable to rates in studies of older adults.

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Centrally Distributed Adiposity Linked to Higher Risk of Fecal Incontinence

Brigham and Women’s Hospital researchers and colleagues hypothesized that central adiposity, not elevated BMI alone, may have a role in fecal incontinence (FI). They report that waist circumference-to-height ratio (WtHR) is a stronger predictor of FI than BMI.

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Driving Innovation in Abdominal Wall Reconstruction

Throughout his career, new Brigham gastrointestinal surgeon O. Yusef Kudsi, MD, MBA, has embodied an entrepreneurial spirit most often seen in the business world. That characteristic helped him develop an international reputation as a hernia surgeon and a pioneer in robotic procedures for abdominal wall reconstruction.

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Noninvasive Prenatal Test Detects Fetal Antigens

Researchers have validated a next generation sequencing (NGS)-based noninvasive prenatal test that uses quantitative counting template technology to detect RhD, C, c, E, K (Kell), and Fya (Dufy) fetal antigengenotypes from maternal blood samples in the ethnically-diverse U.S. population.

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Certain Plasma Metabolites and Metabolite Classes Linked to Persistent Tinnitus

Mass General Brigham researchers recently completed the first human study that examined links between metabolites and persistent tinnitus. They say metabolomic profiling is a promising approach to pinpointing tinnitus biomarkers and should provide valuable insights into the pathophysiology of the disorder.

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Immunoprofiling Can Identify Immune Cell Abnormalities, Guide Care for Patients With Unusual Inflammatory Disease Presentations

Histology of skin human tissue , show epithelium tissue and connective tissue with microscope view

Alisa Mueller, MD, PhD, Takanori Sasaki, MD, PhD, Deepak Rao, MD, PhD, and colleagues have demonstrated that for patients with unusual autoimmune or inflammatory conditions, cellular and transcriptomic immunophenotyping can serve as complementary diagnostic tools and guide treatment decisions.

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Heart Rhythm 2024: Brigham Presents Electrophysiology Research

On May 16 – 19, 2024, faculty from the Heart & Vascular Center at Brigham and Women’s Hospital will join the international electrophysiology community and present their latest research at the Heart Rhythm 2024 annual meeting.

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