Elevated Estradiol on Day of Progesterone Initiation Is Detrimental After Frozen Embryo Transfer

Close up of green tray with researcher removing embryo frozen in liquid nitrogen for IVF procedure

Many IVF programs freeze embryos to mitigate risk of elevated estradiol levels that can negatively affect conception and live birth. However, Brigham researchers determined elevated estradiol levels at the time of progesterone initiation have similarly negative effects on outcomes after frozen embryo transfer cycles.


SGLT2 Inhibitors Should Be Considered Foundational Therapy in All Patients With Heart Failure

Young doctor pointing to illustration of heart anatomy to show a patient sitting in office

Scott D. Solomon, MD, director of the Clinical Trials Outcomes Center at Brigham and Women’s Hospital, and colleagues have concluded that SGLT2 inhibitors should be considered adjunctive therapy for all patients with heart failure, regardless of ejection fraction or care setting.


Dapagliflozin Safe and Effective After Hospitalization for Heart Failure With Mildly Reduced or Preserved Ejection Fraction

Male patient lying in hospital bed smiling up at doctor standing bedside

In a prespecified secondary analysis of the DELIVER trial, Scott D. Solomon, MD, at Brigham and Women’s Hospital, and colleagues found that starting dapagliflozin during or shortly after hospitalization for HF is safe and effective for patients with mildly reduced or preserved ejection fraction.


Both Clinical Features, Assay Results Need Consideration in Diagnosis of MOG-AD

Demyelination of neuron, the damage of the neuron myelin sheath seen in demyelinating diseases

Giovanna S. Manzano, MD, of the Department of Neurology at Brigham and Women’s Hospital, Marcelo Matiello, MD, of Massachusetts General Hospital, and colleagues determined positive predictive values of a live cell–based serum assay that detects the diagnostic biomarker for MOG-AD in a real-world cohort.


Vitamin C Modestly Reduces Risk of New Gout in Men

Vitamin c oval tablets spilling out of pill bottle into a wooden spoon and onto wooden surface

In a large randomized trial, Howard D. Sesso, ScD, MPH, associate director of the Division of Preventive Medicine, and colleagues determined vitamin C supplementation was associated with a lower risk of new gout diagnosis in adult men, whereas supplemental vitamin E had no effect.


Roux-en-Y Gastric Bypass May Not Be As Safe As Sleeve Gastrectomy for Black and Latino/a/x Patients

Black male patient sitting in hospital bed speaking to female doctor

Caroline M. Apovian, MD, and team determined that the variability of weight loss and hemoglobin A1C across racial/ethnic groups was small after Roux-en-Y gastric bypass (RYGB) compared with sleeve gastrectomy (SG). However, safety concerns were greater for Black and Latino patients after RYGB than SG.


Reducing Healthcare Disparities: Q&A With Quoc-Dien Trinh, MD, MBA

Female doctor showing tablet to black male patient in hospital bed

As part of the United Against Racism initiative, Mass General Brigham implemented outreach programs across the system to reduce healthcare disparities. Quoc-Dien Trinh, MD, MBA, discusses the program he co-founded and the research his team is doing to improve care for people of color at Brigham and Women’s Hospital.


Botox Injections Aid in Surgery to Repair Hernias in Abdominal Wall

CT scan of abdominal wall with blue arrows indicating position of needle injections

Select patients with complex ventral hernias may benefit from a technique that employs Botox injections to relax the abdominal muscles before surgery, enabling the surgeon to complete the hernia repair less invasively. The Brigham’s Eric G. Sheu, MD, PhD, and Daniel I. Glazer, MD, discuss the benefits of this approach.


Prospective RCT Finds Full-Dose Anticoagulation Better Than Standard Dose in Severe COVID-19

Female patient on respirator in hospital bed with two doctors monitoring

In COVID-PACT, a 2×2 factorial, randomized, controlled trial that enrolled critically ill patients with COVID-19, researchers at Brigham and Women’s Hospital determined full-dose anticoagulation was superior to standard-dose prophylaxis in reducing the proportion of patients experiencing a thrombotic event.


New Cell Atlas Poised to Support Development of Migraine Therapies

Young woman gripping head in pain from migraine, in home office

Brigham investigators have mapped out a group of cells in the trigeminal ganglia that drive migraine pain, allowing them to further characterize the cells in a way that holds promise for developing new therapeutics. Neurologist and lead author William R. Renthal, MD, PhD, elaborates on the study.