Latest Clinical & Research News
Rachel W. Winter, MD, MPH, at Brigham and Women’s Hospital, and colleagues in Denmark conducted the largest study ever to evaluate weight change during TNF inhibitor therapy for patients with inflammatory bowel disease and report low weight gain overall with infliximab.
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Researchers have shown that a novel molecular signature from a single blood sample can identify women at risk of preeclampsia months before presentation. They also report that molecular signatures accurately track gestational age, independently of clinical factors, and could advance the study of other complications.
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Robert R. Edwards, PhD, of the Center for Pain Management at Brigham and Women’s Hospital, and colleagues conducted the first multicenter study that comprehensively examined clinical, functional, psychosocial and sensory factors as predictors of pain and functional outcomes after total knee arthroplasty.
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There is growing evidence that rheumatoid arthritis (RA) originates in mucosal surfaces and a range of respiratory tract diseases are associated with RA. Now, researchers have demonstrated that the timing of respiratory tract disease diagnosis significantly affects the strength of each disease’s association with RA.
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Elena Aikawa, MD, PhD, Livia S.A. Passos, PhD, of the Heart and Vascular Center at Brigham and Women’s Hospital, and colleagues have identified a protein that contributes to chronic rheumatic heart valve disease (RHVD) immunopathogenesis and has a role in the female predisposition to RHVD.
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The Brigham’s new multidisciplinary Parent Mental Health Program, created by Cindy H. Liu, PhD, and Leena P. Mittal, MD, is designed to provide timely and consistent mental health services for parents and caregivers of infants hospitalized in the neonatal intensive care unit.
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When the COVID-19 lockdown began, the Brigham’s Diabetes Management Program developed a protocol for reaching out to patients whose routine clinic visits were abruptly canceled. A study led by Marie E. McDonnell, MD, revealed two-way communication was necessary to re-engage patients in diabetes care after disruption.
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In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.
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Brigham and Women’s Hospital researchers investigated the prognostic value of premature ventricular contractions (PVCs) in asymptomatic individuals not suspected of having heart disease. High-grade PVCs that occurred during recovery from stress testing were associated with long-term cardiovascular mortality.
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Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.
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