Latest Clinical & Research News
A soon-to-be published study reports a high prevalence of interstitial lung abnormalities (ILA) and undiagnosed interstitial lung disease (ILD) among first-degree relatives of patients with familial pulmonary fibrosis (FPF) and sporadic idiopathic pulmonary fibrosis (IPF). Results suggest screening might be warranted for undiagnosed relatives to facilitate early detection of PF.
A research team from the Department of Neurosurgery at Brigham and Women’s Hospital has published its step-by-step “recipe” for combining microRNAs into genetic therapies. The new publication comes on the heels of earlier work that shows promise for a potential glioblastoma (GBM) gene therapy. In sharing their technique, the researchers hope to help others create transgenes that could target virtually any complex molecular pathway in a broad range of tumors and other disorders.
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Caring for a hospitalized older adult requires the coordinated efforts of various specialists and geriatricians throughout the patient’s hospital stay. At Brigham and Women’s Hospital, an attending physician in the Division of Aging is facilitating such collaboration by developing a co-management service that embeds geriatrics within the hospital’s internal medicine floors.
The Cardiac Amyloidosis Program at Brigham and Women’s Hospital was the first of its kind in the United States. Established 10 years ago by Rodney H. Falk, MD, a widely recognized expert in cardiac amyloidosis, the collaborative program has expanded to diagnose and treat every form of amyloidosis, involving experts from cardiology, cardiac pathology, gastroenterology, hematology, nephrology, oncology and neurology.
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The landmark National Lung Screening Trial found that in high-risk individuals, low-dose CT (LDCT) screening reduced lung cancer mortality by 20 percent relative to chest X-ray. Nine years after those results were published, lung cancer remains by far the leading cause of cancer-related death. And yet, screening for this dangerous disease is lagging.
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As people live longer and lead more active lives in their later years, many opt for elective surgeries to improve their quality of life. With more older people undergoing major surgeries, there has been a dramatic increase in the number of patients developing postoperative delirium and cognitive decline.
Since 2019, Antonia F. Chen, MD, MBA, and several orthopaedic surgeons at Brigham and Women’s Hospital have been performing partial and total knee replacements using robotic-arm assisted surgery.
Immune checkpoint inhibitors have transformed the management of patients with advanced kidney cancer. However, these therapies only work for a subset of patients with advanced disease and can be associated with substantial side effects. As a result, researchers are focused on new therapeutic combinations to boost the effectiveness of current immune therapies in renal cancer, including in patient populations with early-stage disease that is likely to recur.
Affecting more than half of adults in the United States, low back pain, osteoarthritis and musculoskeletal trauma are the three most common musculoskeletal conditions leading to emergency department and physician visits and hospital stays. Nearly $800 billion, or about 5 percent of the U.S. economy, goes towards diagnosing, treating and managing musculoskeletal conditions.
The Department of Orthopaedic Surgery at Brigham and Women’s Hospital is using an innovative digital care platform to manage patients undergoing total hip and knee replacement surgery. Used by several surgeons, including Jeffrey K. Lange, MD, the digital tool enhances clinicians’ ability to deliver comprehensive care around the time of joint replacement surgery by educating, monitoring, and communicating with patients from scheduling to recovery.