Sleep Discontinuity in Perimenopausal Women Linked to Female Reproductive Hormone Patterns

Woman in bed covering face, unable to sleep. Alarm clock on bed reads 3:41

The Brigham’s Jamie Coborn, PhD, Hadine Joffe, MD, and colleagues have published empirical evidence that changing hormone dynamics underlie awakenings in perimenopausal women, independent of vasomotor symptoms.


Cognitive Deficits Present Across Domains in Schizophrenia and Relate to Positive Symptoms

Young woman on couch, emotional, talking with female researcher or doctor who holds a clipboard

Johanna Seitz-Holland, PhD, Marek Kubicki, MD, PhD, of the Department of Psychiatry at the Brigham, and colleagues recently became the first to investigate cognitive deficits in schizophrenia in a large-scale, thoroughly harmonized sample.


Response to Electroconvulsive Therapy for Major Depressive Disorder May Be Mediated by IL-8, White Matter Alterations

Diffusion MRI of a human brain. Brain fibers are highlighted in blue, green, yellow and pink

Researchers at Brigham and Women’s Hospital have related acute neuroinflammatory response and changes in white matter structure after electroconvulsive therapy to each other and treatment outcomes.


Large-scale Collaborative Network Valuable for Research in Bipolar Disorder

Over the shoulder view of female psychiatrist writing on clipboard speaking with male patient

To examine the value of large-scale collaboration, researchers at Brigham and Women’s Hospital and colleagues worldwide recently determined core predictors of functional outcome in bipolar disorder, independent of treatment organization or societal differences.


Adults With TBI May Benefit From Screening for Cardiometabolic Disease, Other Comorbidities

Female doctor shows brain scan images to older male patient in hospital bed

An analysis of prospectively collected data has demonstrated that adults who sustain traumatic brain injury (TBI), regardless of age and injury severity, are at higher risk of certain cardiovascular, endocrine, neurologic, and psychiatric disorders.


Brigham Researchers Take a Closer Look at Lithium’s Effects on the Brain

Close up of a pile of pink lithium tablets with "223" imprinted on one side

Through brain imaging and laboratory research, Brigham investigators are examining how lithium affects the brain at the individual neuron and brain-circuit levels. Psychiatrist Amit Anand, MD, explains how it may increase the growth of certain areas of the brain and influence the organ functionally and structurally.


Sensitive Cognitive Outcomes Preclinical Alzheimer’s Disease Trials

3D rendering of Beta-amyloid found in Alzheimer's disease.

Kathryn V. Papp, PhD, and Reisa A. Sperling, MD, at Brigham and Women’s Hospital, and colleagues recently determined that very early Alzheimer’s disease is associated with a decline in existing measures of processing speed and memory retrieval.


Black Elders Show Greater Posttraumatic Growth During COVID-19 Than White Elders

Black older man sitting at edge of bed wearing COVID-19 mask

Patrizia Vannini, PhD, of the Department of Neurology, and colleagues conducted the first study of posttraumatic growth and other mental health factors related to COVID-19 among older adults. They describe how the pandemic affected Black and white older adults differently and name ways to foster posttraumatic growth.


Presurgical Physical, Psychosocial and Sensory Factors All Influence Total Knee Arthroplasty Outcomes

Doctor evaluates patient knee suture scar after total knee arthroplasty

Robert R. Edwards, PhD, of the Center for Pain Management at Brigham and Women’s Hospital, and colleagues conducted the first multicenter study that comprehensively examined clinical, functional, psychosocial and sensory factors as predictors of pain and functional outcomes after total knee arthroplasty.


Inside the NICU: When the Parent Becomes the Patient

Close up of doctor's hands holding a newborn in the NICU

The Brigham’s new multidisciplinary Parent Mental Health Program, created by Cindy H. Liu, PhD, and Leena P. Mittal, MD, is designed to provide timely and consistent mental health services for parents and caregivers of infants hospitalized in the neonatal intensive care unit.