About one-third of epilepsy patients have a disease that is considered drug-resistant, meaning they have failed at least two medications. For these individuals, neurosurgical procedures offer the best chance of bringing their disease under control. Remarkably, the average time it takes for someone with…

Although current surgical approaches for treating drug-resistant epilepsy are already good, researchers at the Brigham are focused on developing treatments that are even more effective and less invasive. John David Rolston, MD, PhD, director of Epilepsy Surgery, highlights some of these promising efforts.

Brigham and Women’s Hospital researchers have confirmed in a large cohort what previous research suggested: a lack of correlation between subjective dysautonomia and standardized objective testing.

Using deep brain stimulation (DBS) as a research tool, Brigham and Women’s Hospital scientists have identified distinct neural circuits for Parkinson’s disease, dystonia, obsessive-compulsive disorder (OCD), and Tourette’s syndrome.

Researchers at Brigham and Women’s Hospital are using neurons derived from induced pluripotent stem cells (iNs) as a highly controlled, reproducible model system for understanding cellular pathways that mediate neuropathogenesis directly downstream of genetic risk factors.

Mutations in human presenilin genes (PSEN1 and PSEN2) are the major cause of early-onset familial Alzheimer’s disease (FAD). Building on the previous work, Brigham reserachers have published preclinical evidence that using gene therapy to deliver a functional copy of PSEN1 may someday be able to treat FAD.

The American Academy of Neurology (AAN) will hosts its 2024 annual meeting on April 13 – 18 in Denver, CO and virtually. Faculty from the Department of Neurology at Brigham and Women’s Hospital will join thousands of international colleagues in presenting their latest research at AAN 2024.

Cerebral proliferative angiopathy (CPA) is a cerebral vascular malformation with distinctive features. Brigham and Women’s Hospital researchers present one of the few reports of long-term follow-up of a patient with hemorrhage in CPA: 32 years of data on a patient who had recurrent hemorrhage.

Timothy Smith, MD, PhD, MPH, a neurosurgeon-scientist in the Brigham’s Department of Neurosurgery, is exploring how to utilize artificial intelligence and machine learning to optimize neurosurgical patient care. He is co-author of three papers that offer a glimpse into how these technologies are transforming the field.