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For couples with recurrent miscarriage (RM), the condition remains unexplained in about 40 to 60 percent, even after costly testing. Chromosomal abnormalities—rearrangements of large chunks of DNA—in the genomes of one or both individuals trying to conceive are thought to be among the major genetic causes of RM. But routine chromosome analysis (karyotyping) can currently detect these abnormalities in only about 1 in 50 couples.

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Vesela Kovacheva, MD, PhD, was not thinking about her work as an obstetric anesthesiologist when she opened an article about artificial intelligence (AI) in 2017, expecting to learn about self-driving cars and the algorithms behind online shopping.
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Strong evidence that now connects preeclampsia with long-term maternal cardiovascular risks raises new questions for obstetricians (OBs):  What is the best way to care for women after preeclampsia? And, what postpartum care and support might help women minimize immediate and long-term risks?
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Jon I. Einarsson, MD, MPH, didn’t set out to be an inventor. Chief of the Division of Minimally Invasive Gynecologic Surgery at Brigham and Women’s Hospital, Einarsson is a champion of minimally invasive approaches for their benefits to patients. But as a teacher and mentor, he knows that some techniques that benefit patients are slightly more challenging technically for trainees and others to master.
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For women who want their own biological children, a diagnosis of infertility due to a lack of viable eggs can be devastating. Ovarian failure in women can have many causes, including aging, autoimmune disease and exposure to radiation therapy and certain chemotherapy drugs.
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An online intervention program for women who recently had preeclampsia has produced insight into how to reduce their future risks of cardiovascular disease.

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As genetic and genomic sequencing become incorporated into newborn screening for hearing loss, patients may look to obstetricians for guidance on genetic testing decisions.

Auditory screening of newborns, mandated by most states in recent decades, now reaches an estimated 98 percent of newborns in the United States and has significantly reduced the average age for identifying congenital deafness. But adding genetic testing could drive more accurate diagnosis and personalized management during infancy’s critical window when the brain’s speech and language center is developing rapidly.
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Predicting which IVF embryos are most likely to produce a healthy pregnancy is an ongoing challenge in the field. For embryologist Catherine Racowsky, PhD, it is a theme across her varied work as director of the IVF Lab at Brigham and Women’s Hospital, as a researcher of new techniques to find the healthiest embryos and as incoming president of the American Society of Reproductive Medicine.

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With placenta accreta contributing to rising rates of severe maternal morbidity nationwide, the Program for Surgical Obstetrics and Placental Abnormalities at Brigham and Women’s Hospital is zeroing in on antepartum risk stratification as a tool for preserving maternal health.
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