Researchers at the Brigham have demonstrated that mice with ovarian failure caused by chemotherapy can have their fertility restored using induced pluripotent stem cells (iPSCs). Not only were the mice able to make functional eggs from the iPSCs, but those eggs developed into pups that were able to reproduce.

U.S. News & World Report 2023-24 ranks Brigham and Women’s Hospital #1 in the nation for Obstetrics and Gynecology for the second consecutive year. Department Chair Nawal Nour, MD, MPH, celebrates this major accomplishment by reflecting on the team’s commitment to providing comprehensive, equitable OB/GYN care.

Mass General Brigham researchers have conducted the first study to evaluate pregnancy rates in intrauterine insemination according to both total motile count (TMC) and stimulation regimen. They report encouraging data for many patients with insemination TMC <10 million.

Brigham and Women’s Hospital and Boston Children’s Hospital have performed the first-ever in-utero cerebrovascular surgery in the U.S. They successfully treated an aggressive vascular malformation in an infant’s brain before birth, preventing potentially fatal symptoms after delivery.

There are no published guidelines that address oocyte retrieval techniques for assisted reproduction. Brigham and Women’s Hospital researchers surveyed physicians about their own techniques, and although no clear top-performing technique was evident, the team suggests some principles to follow.

Andrea Lanes, MSc, PhD, of the Department of Obstetrics and Gynecology at Brigham and Women’s Hospital, and colleagues recently became the first to compare outcomes of ovarian stimulation and embryo transfer for oligoanovulatory patients with hypothalamic hypogonadism versus polycystic ovary syndrome.