Total Motile Count of 2 Million Proposed As Threshold for Intrauterine Insemination

Patient at consultation with doctor, intrauterine insemination concept

Mass General Brigham researchers have conducted the first study to evaluate pregnancy rates in intrauterine insemination according to both total motile count (TMC) and stimulation regimen. They report encouraging data for many patients with insemination TMC <10 million.


First-ever In Utero Cerebrovascular Surgery for Vascular Malformation a Success

Ultrasound image of baby's head during hospital visit

Brigham and Women’s Hospital and Boston Children’s Hospital have performed the first-ever in-utero cerebrovascular surgery in the U.S. They successfully treated an aggressive vascular malformation in an infant’s brain before birth, preventing potentially fatal symptoms after delivery.


No Optimal Technique Identified for Oocyte Retrieval But Certain Principles Apply

In vitro fertilization of a human female cell on a blue background. Microscopic view, 3d rendering

There are no published guidelines that address oocyte retrieval techniques for assisted reproduction. Brigham and Women’s Hospital researchers surveyed physicians about their own techniques, and although no clear top-performing technique was evident, the team suggests some principles to follow.


Both Cervical and Systemic Innate Immunity Predictors of HIV Risk Are Associated With HSV-2 Acquisition

3D illustration of herpes simplex virus (HSV) on plain blue background

Building on previous findings, Brigham and Women’s Hospital researchers report that the immunity imbalance predisposing to herpes simplex virus-2 (HSV-2) isn’t limited to the cervix but rather extends to the systemic circulation. HSV-2 may alter both mucosal and peripheral innate immunity to contribute to HIV-1 risk.


Anxiety Among Perinatal Women During COVID-19 More Likely for Those Without Prior GAD

A pregnant woman in deep thought looking out a window, anxiety during COVID-19 concept

Researchers at Brigham and Women’s Hospital investigated whether pre-existing anxiety exacerbated COVID-19–related health concerns among women who entered perinatal status early in the pandemic. They found the opposite: levels of COVID-19–related worry were greater among women without a pre-existing anxiety diagnosis.


Novel Text Messaging Program Encourages Women With Gestational Diabetes to Self-Monitor Their Glucose

Over the shoulder view of woman outside texting on smartphone

Brigham and Women’s Hospital team has developed an automated two-way text messaging program designed to encourage self-monitoring of blood glucose in women with gestational diabetes mellitus.


Counseling About Assisted Reproduction for Oligoanovulation Should Be Tailored to Specific Diagnosis

Close up of hand pulling out liquid nitrogen straws with frozen embryos and egg cells from dewar

Andrea Lanes, MSc, PhD, of the Department of Obstetrics and Gynecology at Brigham and Women’s Hospital, and colleagues recently became the first to compare outcomes of ovarian stimulation and embryo transfer for oligoanovulatory patients with hypothalamic hypogonadism versus polycystic ovary syndrome.


Perioperative Use of Pain Medications Similar for Vaginal and Laparoscopic Repair of Pelvic Organ Prolapse

Female patient in hospital bed recovering after surgery, holding mug and looking out bright window

Minimally invasive surgery is often promoted as a way to reduce postoperative pain after benign gynecological surgery. However, Brigham researchers found vaginal and laparoscopic hysterectomy for treatment of pelvic organ prolapse appear to be similar with regard to postoperative pain medication requirements.


Sleep Discontinuity in Perimenopausal Women Linked to Female Reproductive Hormone Patterns

Woman in bed covering face, unable to sleep. Alarm clock on bed reads 3:41

The Brigham’s Jamie Coborn, PhD, Hadine Joffe, MD, and colleagues have published empirical evidence that changing hormone dynamics underlie awakenings in perimenopausal women, independent of vasomotor symptoms.


Elevated Estradiol on Day of Progesterone Initiation Is Detrimental After Frozen Embryo Transfer

Close up of green tray with researcher removing embryo frozen in liquid nitrogen for IVF procedure

Many IVF programs freeze embryos to mitigate risk of elevated estradiol levels that can negatively affect conception and live birth. However, Brigham researchers determined elevated estradiol levels at the time of progesterone initiation have similarly negative effects on outcomes after frozen embryo transfer cycles.