Endoscopic Ultrasound–guided Gastroenterostomy Is a Viable Option for Palliation of Gastric Outlet Obstruction

Medical professional holding instrument for endoscopy with purple gloves

Ali Abbas, MD, MPH, Christopher C. Thompson, MD, MSc, and colleagues report similar technical success rates for endoscopic ultrasound–guided gastroenterostomy (EUS-GE) and surgical gastrojejunostomy, despite more advanced cancer stage and worse performance status in the EUS-GE cohort.


Novel Treatment May Improve Transplant Outcomes in Patients With Obesity

Bariatric surgery in operating room with surgeon looking at monitor

In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.


Working Outside of the Operating Room to Advance Surgical Care

Headshot of Douglas S. Smink, MD, MPH

Having dedicated his career to patient care, education and research, Douglas S. Smink, MD, MPH, embodies the classic tripartite mission of an academic medical center. He discusses his experience leading the Association of Program Directors in Surgery as well as his research on innovative gastrointestinal training.


Oral Drug Developed at the Brigham Replicates Metabolic Benefits of Gastric Bypass

3d Rendering of gastric bypass on red background

Since many patients with diabetes are ineligible for RYGB or decline it, researchers at Brigham and Women’s Hospital developed an orally administered gut barrier coating for improving glucose homeostasis.


One-stage Approach to Converting Laparoscopic Adjustable Gastric Band to Sleeve Gastrectomy Found Safe, Effective

3D rendering of stomach with a gastric band

Scott Shikora, MD, director of Metabolic and Bariatric Surgery in the Center for Weight Management and Wellness at the Brigham, and colleagues conclude one-stage laparoscopic adjustable gastric band to sleeve gastrectomy conversion is safe and effective when performed by experienced surgeons.


Lower Steroid Dose for Initial Management of Hepatitis Secondary to Immune Checkpoint Inhibitors

3D concept of a human liver with hepatitus virus

Researchers at Brigham and Women’s Hospital conducted the first study to compare the outcomes of different steroid dosing regimens prescribed for patients with high-grade ICI hepatitis. Stephen D. Zucker, MD, Shilpa Grover, MD, MPH, Michael Li, MD, MPH, and colleagues present evidence for starting with the lower dose.


Home Hospital for Surgery: An Emerging Option for Perioperative Care

Headshot of Thomas C. Tsai, MD, MPH on black background

Home hospital programs are a safer, cheaper and more efficacious alternative to inpatient hospital admission for many medical conditions. The Brigham is at the forefront of efforts to extend this delivery model to perioperative care, including for GI and bariatric surgery. Thomas C. Tsai, MD, MPH, discusses this work.


Laparoscopic Sleeve Gastrectomy Has Profound Effects on Immune Cells

3D rendering of laparoscopic sleeve gastrectomy

Research at Brigham and Women’s Hospital explored how laparoscopic sleeve gastrectomy improves the systemic inflammatory profile and found pronounced improvement in immune cell composition, function and metabolism, as measured by both biomarkers and gene expression, as soon as three months after the procedure.


Anorectal Dysfunction Can Have a Role in Chronic Opioid-induced Constipation

Walter Chan, MD, MPH, director of the Center for Gastrointestinal Motility at the Brigham, Nayna Lodhia, MD, associate physician in the Division of Gastroenterology, Hepatology and Endoscopy, and colleagues have documented anorectal dysfunction in patients with chronic constipation who used opioids.


“Self-tunable” Engineered Yeast Probiotics May Allow Precision Treatment of IBD

Francisco J. Quintana, PhD, Cristina Gutiérrez-Vázquez, PhD, and colleagues engineered yeasts that generate an immunosuppressive molecule in direct proportion to the amount of a pro-inflammatory metabolite produced in the inflamed gut. They describe their new treatment platform and the results.