Transoral Outlet Reduction Plus Pharmacotherapy Superior to Either Alone for Treating Weight Regain After RYGB

Brigham and Women’s Hospital researchers, and colleagues investigated the effect of combining pharmacotherapy with transoral outlet reduction. They demonstrate the combination is superior to either therapy alone and provides similar efficacy to surgical revision for weight gain after Roux-en-Y gastric bypass.


Improved Ingestible Sensor for Wireless Monitoring of the GI Tract Is Location-Aware

Doctor pointing to outline of gastrointestinal tract, GI

Researchers at Brigham and Women’s Hospital, MIT, and California Institute of Technology have devised a system for localizing and tracking wireless microdevices inside the GI tract in real-time and in non-clinical settings, with millimeter-scale spatial resolution and no need for X-ray radiation.


Clinic Screens High-Risk Patients to Reduce Incidence of Anal Cancer

HSIL pathology slide

A Brigham clinic offers high-resolution anoscopy to screen for anal dysplasia in people at increased risk of anal cancer due to HPV infection, HIV status, and other factors. Co-founders James Yoo, MD, and Jennifer A. Johnson, MD, explain their mission to reduce the incidence of anal cancer in high-risk populations.


Brigham Team Discovers Mechanism of Th17 Cell Production in the Gut

Rendering of Interleukin 17, a cytokine produced by T-helper cells, on black background

Brigham and Women’s Hospital recently determined how epithelial cells promote Th17 cell generation in response to bacterial colonization as a step toward better understanding the treatment—and even prevention—of chronic inflammatory diseases.


How Can Surgeons Contribute Once Their Operating Days Are Over?

Headshot of Pardon R. Kenney, MD, MS

After decades as a practicing surgeon, Pardon R. Kenney, MD, MS, was ready to step away from the operating room—but not from medicine or his love of teaching. In the Brigham’s new Section of Surgical Educators, he now shares the knowledge he has amassed with new medical students, residents, and attending physicians.


The Brigham at Digestive Disease Week 2023

Speaker at Business Conference and Presentation. Audience at the conference hall.

Brigham and Women’s Hospital is honored to participate in the 2023 Digestive Disease Week (DDW) annual meeting on May 6-9 in Chicago, IL. This is the world’s premier meeting for physicians, researchers, and industry in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.


Endoscopic Gastric Plication Reduces Fibrosis in Patients With Obesity and NAFLD

Close up Doctor point out the computer screen, report of gastrointestinal endoscopy, medical imaging EGD looking for structures in the esophagus.Medical image concept.

Researchers at Brigham and Women’s Hospital have linked endoscopic gastric plication (also called distal primary obesity surgery endoluminal, or POSE) to significant improvement in liver-related outcomes in patients with obesity, nonalcoholic fatty liver disease, and clinically significant hepatic fibrosis.


Clinical and Allergy Profiles of Eosinophilic Esophagitis Differ From GERD

Walter Chan, MD, PhD, of Brigham and Women’s Hospital, and colleagues have reported supporting evidence that proton pump inhibitor (PPI)–responsive eosinophilic esophagitis (EoE) is clinically similar to PPI-nonresponsive EoE and significantly different from erosive esophagitis.


Durable Diabetes Remission More Likely After Bariatric Surgery Than Medical/Lifestyle Therapy

Team of surgeons in operating room

Few surgeons perform metabolic surgery for type 2 diabetes treatment, citing inadequate evidence, and for the same reason, many health insurance plans don’t cover it. Long-term supportive efficacy data from the largest randomized cohort has been published.