Durable Diabetes Remission More Likely After Bariatric Surgery Than Medical/Lifestyle Therapy

Team of surgeons in operating room

Few surgeons perform metabolic surgery for type 2 diabetes treatment, citing inadequate evidence, and for the same reason, many health insurance plans don’t cover it. Long-term supportive efficacy data from the largest randomized cohort has been published.


Second-generation Transoral Incisionless Fundoplication Reduces Symptoms of Atypical GERD

A systematic review and meta-analysis by researchers at Brigham and Women’s Hospital indicates second-generation transoral incisionless fundoplication (TIF 2.0) is effective for atypical GERD (laryngopharyngeal reflux) and improves patient-centered outcomes.


Multisystems Approach Identifies Environmental Chemicals That Promote Intestinal Inflammation

Researchers at Brigham and Women’s Hospital are using an integrated systems approach—a publicly available database, zebrafish chemical screens, machine learning and mouse models—to identify environmental chemicals that promote intestinal inflammation.


Enhanced Recovery Pathway Boosting Postsurgical Outcomes in Peritoneal Metastasis Patients

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve clinical outcomes and prognosis in patients with peritoneal metastasis. However, it is associated with a significant complication rate and a long postsurgical recovery in the hospital.
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Updated Guidelines: Enhanced Recovery Protocols for Colon and Rectal Surgery

Patient in hospital bed with doctor holding their hand, recovery after surgery

The American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons published revised joint guidelines for developing enhanced recovery protocols for elective colon and rectal resection. Jennifer L. Irani, MD, at Brigham and Women’s Hospital, served as co–first author.


Gastroenterology Fellowship Leaders Perceive Multiple Benefits of GI Hospitalists

Doctor standing next to patient recovering in bed at hospital, inpatient

Clinicians in the Department of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital and colleagues explored the prevalence and perceptions of the GI hospitalist model in academic GI departments across the United States. They report GI hospitalists are relatively common and geographically diverse.


Transcriptional Profile Overlaps in PPI-Responsive and -Nonresponsive Eosinophilic Esophagitis

Esophagram or Barium swallow front view showing esophagus for diagnosis

Researchers at Brigham and Women’s Hospital hypothesized that differences in mucosal gene transcript expression might explain the differences in PPI treatment response. Instead, they found the transcriptional profiles in patients with PPI-responsive and -nonresponsive eosinophilic esophagitis are remarkably similar.


Actively Triggerable Aluminum for Gastrointestinal Applications

Gallium, a silvery, soft metal, melting on palm of outstretched hand

Researchers in the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and MIT address limitations of metals in medical devices by using liquid metal embrittlement, long viewed as a failure mechanism to be avoided, to stimulate on-demand breakdown of solid aluminum.


Intelectin-1 Contributes to the Severity of Ulcerative Colitis

Molecular model of human intelectin-1 on green and purple background

Researchers at Brigham and Women’s Hospital recently presented evidence of novel mechanisms by which intelectin-1 may affect an individual’s susceptibility to inflammation in the colon.