How Can Doctors Predict Patient Response to Weight Loss Surgery?

Diagram of digestive anatomy on white background, showing Roux-en-Y gastric bypass procedure

Brigham researchers found that patients with higher pre-operative levels of the hunger hormone ghrelin respond better to gastric bypass surgery than those with lower levels. Minimally invasive and bariatric surgeon Ali Tavakkoli, MD, says this suggests a crucial role for ghrelin in driving postoperative outcomes.


Editorial: GI Testing in Patients With Limited English Proficiency

Older male patient speaks to young female doctor with clipboard, both sitting at desk

A study at the Mayo Clinic is the first to examine broadly and systematically the impact of patients’ limited English proficiency (LEP) on procedure-related gastroenterology care. In an editorial, Mass General Brigham clinicians comment on the study results, its limitations, and directions for additional research.


Brigham Hosts Country’s First High-Resolution Anoscopy Course for Colorectal Surgery Fellows

Five researchers standing in a line inside a lab smiling at camera

High-resolution anoscopy can be a helpful tool for identifying precancerous lesions in the anal canal. Colon and rectal surgeon James Yoo, MD, and infectious disease specialist Jennifer A. Johnson, MD, both of the Brigham, developed and recently hosted a course to educate colorectal fellows on the technique.


Roux-en-Y Gastric Bypass May Not Be As Safe As Sleeve Gastrectomy for Black and Latino/a/x Patients

Black male patient sitting in hospital bed speaking to female doctor

Caroline M. Apovian, MD, and team determined that the variability of weight loss and hemoglobin A1C across racial/ethnic groups was small after Roux-en-Y gastric bypass (RYGB) compared with sleeve gastrectomy (SG). However, safety concerns were greater for Black and Latino patients after RYGB than SG.


Botox Injections Aid in Surgery to Repair Hernias in Abdominal Wall

CT scan of abdominal wall with blue arrows indicating position of needle injections

Select patients with complex ventral hernias may benefit from a technique that employs Botox injections to relax the abdominal muscles before surgery, enabling the surgeon to complete the hernia repair less invasively. The Brigham’s Eric G. Sheu, MD, PhD, and Daniel I. Glazer, MD, discuss the benefits of this approach.


Transoral Incisionless Fundoplication Cost-Effective for Treatment of GERD

Blue outline of human anatomy showing GERD highlighted red, acid reflux in stomach

Thomas R. McCarty, MD, MPH, Christopher C. Thompson, MD, and colleagues recently constructed a computer model to evaluate the cost-effectiveness of various strategies for treating gastroesophageal reflux disease (GERD) that is refractory to standard-dose proton pump inhibitor (PPI) therapy.


Pilot Study: Gastroplasty With Endoscopic Myotomy for Treatment of Obesity

Gastroenterologist holds black endoscope device in hospital setting

Christopher C. Thompson, MD, director of endoscopy and co-director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital, and colleagues are studying a novel bariatric and metabolic procedure to weaken the antral pump, a major physiologic component of gastric emptying.


Brigham Researchers Create COVID-19 Genome Catalog of the Human Microbiome

3D rendering of the human gut microbiome, with different gut species

Researchers at Brigham and Women’s Hospital analyzed whole-metagenome shotgun (WMS) sequencing data by reconstructing microbial population genomes directly from microbiome samples of COVID-19 patients and controls. They report the creation of the first high-quality COVID-19–related genome catalog of the gut microbiome.


Symptoms of Suspected Laryngopharyngeal Reflux Correlate Poorly With Hypopharyngeal–Esophageal Multichannel Intraluminal Impedance–pH

Woman sitting holding chest and stomach, red highlight on upper chest for reflux discomfort

Sanjay Salgado, MD, Walter W. Chan, MD, PhD, and colleagues recently found no correlation between suspected laryngopharyngeal reflux symptoms and hypopharyngeal–esophageal multichannel intraluminal impedance–pH (HEMII-pH) results.


Novel Method of Delivering Therapeutic CO Fights Inflammation

Medically accurate rendering of inside an inflammed colon

Giovanni Traverso, MD, PhD, MBBCH, of Brigham and Women’s Hospital and MIT, and colleagues have incorporated CO into gas-entrapping materials (GEMs) that can be delivered safely to the digestive tract.