Mineralocorticoid Receptor Antagonists Have No Meaningful Role in Treating Primary Hyperparathyroidism

Aldosterone scientific molecular model, 3D rendering

Colleagues from the Brigham’s Center for Adrenal Disorders assessed the efficacy of aldosterone antagonism with a mineralocorticoid receptor (MR) antagonist versus placebo in patients with primary hyperparathyroidism (P-HPT). They provide evidence that MR antagonists have no meaningful role in P‐HPT treatment.

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MKRN3 Gene Linked to Delayed Puberty

3D rendering of colorful DNA sequences in and out of frame, gene concept

Based on findings from a novel mouse model, researchers at Brigham and Women’s Hospital led by Ursula B. Kaiser, MD, suggest that genetic variants resulting in increased MKRN3 expression may be a previously unrecognized cause of delayed puberty.

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Review: Strengthening Diabetes Care in Humanitarian Crises in Low- and Middle-income Countries

Woman using syringe to extract insulin from bottle, diabetes care concept

Sylvia Kehlenbrink, MD, endocrinologist and director of Global Endocrinology at Brigham and Women’s Hospital, and colleagues outline challenges and possible solutions for providing diabetes care during acute and prolonged humanitarian crises.

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Brigham Endocrinologist Is Lead Author of Updated Clinician’s Guide on Osteoporosis

Headshot of female doctor in white coat, smiling and standing in hallway

Lead author Meryl S. LeBoff, MD, discusses the new Bone Health and Osteoporosis Foundation’s “Clinician’s Guide to Prevention and Treatment of Osteoporosis,” along with the urgency of enhancing the prevention, risk management, diagnosis, and treatment of osteoporosis in postmenopausal women and men aged 50+ years.

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Relative Hyperglycemia Is a Marker of Disease Severity in COVID-19

Patient in hospital bed with COVID, two nurses in PPE stand beside bed writing on clipboard

The “glycemic gap” has previously been validated as a predictor of severe acute illness. Now, Brigham and Women’s Hospital researchers have extended the glycemic index’s utility to COVID-19.

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Vitamin D Supplementation Does Not Influence Fracture Risk in the General Population

Hand holding a vitamin d supplement pill up to the sky, with bright sun

To address conflicting evidence, Meryl S. LeBoff, MD, JoAnn E. Manson, MD, PhD, MPH, and colleagues conducted an ancillary analysis of the Vitamin D and Omega-3 Trial (VITAL). They found vitamin D did not affect fracture risk in the general population.

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Roux-en-Y Gastric Bypass May Not Be As Safe As Sleeve Gastrectomy for Black and Latino/a/x Patients

Black male patient sitting in hospital bed speaking to female doctor

Caroline M. Apovian, MD, and team determined that the variability of weight loss and hemoglobin A1C across racial/ethnic groups was small after Roux-en-Y gastric bypass (RYGB) compared with sleeve gastrectomy (SG). However, safety concerns were greater for Black and Latino patients after RYGB than SG.

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Can a Fatty Acid Supplement Improve Outcomes in People With Obesity and Prediabetes?

Yellow oil capsules spilling out of brown bottle onto table

Brigham researchers are looking at novel ways to boost natural mechanisms that the body uses to counteract the pathogenesis of obesity and its complications. An upcoming clinical trial led by Mehmet Furkan Burak, MD, explores the impact of dietary supplementation with palmitoleic acid in obese, prediabetic individuals.

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Dapagliflozin Efficacious, Safe in Type 2 Diabetes Regardless of Pre-Treatment Systolic BP

Close up of blood pressure monitor screen reading 100 over 156

SGLT2 inhibitors like dapagliflozin reduce hospitalization for heart failure and progression of diabetic nephropathy in patients with type 2 diabetes, but decrease systolic and diastolic blood pressure only minimally. Brigham researchers investigated whether their efficacy might depend on pre-treatment blood pressure.

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