Review: Efficacy and Safety of Testosterone for Older Adults With Functional Limitations

Close up of old man's hands holding wooden cane, seated

Testosterone is a leading candidate for preventing and treating age-related loss of muscle mass, strength, power, and physical function. In this review, Brigham and Women’s Hospital researchers critically appraise several suppositions about using testosterone in older adults with functional limitations.


ENDO 2023: Brigham Leaders Present Latest Endocrinology Advancements

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Leaders from the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital are honored to join international colleagues at the world’s premier event in endocrinology research and clinical care: the Endocrine Society Annual Meeting. ENDO 2023 takes place June 15–18 in Chicago, IL.


Embedding Diabetes Care in the Latino Community

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The Brigham’s new approach to providing diabetes care for Latino/Hispanic patients involves embedding diabetes specialists in community clinics and offering culturally and linguistically appropriate services to help patients control their disease and its complications, as A. Enrique Caballero, MD, explains.


Endoscopic Gastric Plication Reduces Fibrosis in Patients With Obesity and NAFLD

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Researchers at Brigham and Women’s Hospital have linked endoscopic gastric plication (also called distal primary obesity surgery endoluminal, or POSE) to significant improvement in liver-related outcomes in patients with obesity, nonalcoholic fatty liver disease, and clinically significant hepatic fibrosis.


Durable Diabetes Remission More Likely After Bariatric Surgery Than Medical/Lifestyle Therapy

Team of surgeons in operating room

Few surgeons perform metabolic surgery for type 2 diabetes treatment, citing inadequate evidence, and for the same reason, many health insurance plans don’t cover it. Long-term supportive efficacy data from the largest randomized cohort has been published.


Stark Differences Found in Hospital-level Patterns of Nonoperative Management for Low-risk Thyroid and Kidney Cancers

A growing set of low-risk cancers, including early-stage thyroid and kidney cancers, is associated with excellent outcomes regardless of management strategy. Given the risks associated with overtreatment of these cancers, it follows that many patients should be treated nonoperatively. Read More

Women Substantially More Likely Than Men to Decline Statin Therapy

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In the first large, population-based cohort study of the issue, researchers at Brigham and Women’s Hospital found 22% of eligible patients declined statin therapy initially and 6% never accepted the recommendation. Results on both measures were significantly higher for women than men.


Primary Aldosteronism: A Prevalent, Yet Grossly Underrecognized Cause of Hypertension

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The Brigham’s Anand Vaidya, MD, MMSc, and Jenifer Michelle Brown, MD, have led studies showing that primary aldosteronism (PA) is much more prevalent than assumed—and may be a causative mechanism for 15%–24% of primary hypertension cases. Now, they are expanding PA screening among high-risk patient populations.


Benefits of Electronic Health Records in the Management of Hypogonadal Men

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Electronic health records (EHRs) have multiple benefits for both clinicians and patients, but can lead to clinician burnout. Martin Kathrins, MD, and Anna Goldman, MD, of Brigham and Women’s Hospital, discuss how EHRs can optimize the treatment of hypogonadal men.


LSD1 Modifies Aldosterone Synthesis in a Sex-specific Manner

3d rendered medical illustration of a woman's adrenal glands highlighted orange

Brigham researchers reinforce previous studies showing LSD1 heterozygote knockout mice displayed altered aldosterone secretion/MR activation in an age- and sex-dependent manner, and for the first time, they report that even at the level of aldosterone biosynthesis, there is an effect of biological sex.