Latest Clinical & Research News
Mutations in human presenilin genes (PSEN1 and PSEN2) are the major cause of early-onset familial Alzheimer’s disease (FAD). Building on the previous work, Brigham reserachers have published preclinical evidence that using gene therapy to deliver a functional copy of PSEN1 may someday be able to treat FAD.
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Brigham researchers have developed a method for identifying hidden genetic contributors to disease by applying various stress tests to human blood cells. The evoked cellular response traits they observed pinpointed genes and pathways relevant to multiple cardiometabolic and inflammatory diseases.
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The American Academy of Neurology (AAN) will hosts its 2024 annual meeting on April 13 – 18 in Denver, CO and virtually. Faculty from the Department of Neurology at Brigham and Women’s Hospital will join thousands of international colleagues in presenting their latest research at AAN 2024.
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Brigham researchers conducted a first-of-its-kind retrospective study to better understand the subset of bariatric surgery patients who do not comply with recommended follow-ups that would help optimize long-term outcomes. Ali Tavakkoli, MD, chief of the Division of General and GI Surgery, discusses their findings.
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After analyzing data from pivotal trials, researchers at Brigham and Women’s Hospital believe treatment with a combination SGLT2i, GLP-1 RA, and nonsteroidal MRA has the potential to improve survival in patients with type 2 diabetes and at least moderately increased albuminuria.
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Brigham and Women’s Hospital cardiovascular experts will present their latest research at this year’s American College of Cardiology 2024 Scientific Session & Expo, held April 6–8 in Atlanta, GA.
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An independent association between urinary incontinence (UI) and depression has been established, but it’s unclear which individuals with UI are at greatest risk of depression. In a new analysis, Brigham and Women’s Hospital researchers report the risk is greatest among men and socioeconomically disadvantaged people.
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Richard Iorio, MD, in the Department of Orthopaedic Surgery at Brigham and Women’s Hospital, and team completed the first study to provide evidence that CT scans are not a useful adjunct to MRI when the Revised ARCO Staging System for osteonecrosis of the femoral head is used for diagnosis and treatment decisions.
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Rahul S. Dalal, MD, MPH, at Brigham and Women’s Hospital, and colleagues recently completed a nationwide study of the use of analgesics for IBD according to age at disease onset. They report individuals with older adult–onset of IBD were more commonly prescribed analgesic medications, compared with other age groups.
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Cerebral proliferative angiopathy (CPA) is a cerebral vascular malformation with distinctive features. Brigham and Women’s Hospital researchers present one of the few reports of long-term follow-up of a patient with hemorrhage in CPA: 32 years of data on a patient who had recurrent hemorrhage.
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