Predictors of Healthcare Spending Identified in Patients With Gout Using Urate-lowering Therapy

Female patient in office signing paperwork across from doctor

Researchers at Brigham and Women’s Hospital identified three distinct groups of gout patients according to their patterns of total spending on health care. The team provides information on identifying patients with gout who could benefit from interventions to reduce long-term spending.


Operative Time Influences Rate of Complications After Radical Cystectomy

Blue rendering with urinary system anatomy highlighted including kidneys and bladder

Radical cystectomy (RC) is a complex procedure requiring the urinary system’s reconstruction. Brigham and Women’s Hospital researchers, including Lorine Haeuser, MD, and Matthew Mossanen, MD, MPH, report higher complication rates after both extremely short and extremely long RC procedures.


Work Relative Value Units Correlate Well With Mean Operative Time in Multiple Specialties

Close up of three medical professionals operating on patient

Surgeons commonly voice the opinion that work relative value units (wRVUs) do not accurately quantify surgeon workload or determine appropriate reimbursement. Brigham researchers investigated and found wRVUs correlate well with mean operative time for the most common surgical procedures across various specialties.


Tiny Devices, Big Insights: A New Way to Predict Drug Response in Prostate Tumors

Researcher looking at microscope

Brigham researchers are closer to being able to predict a patient’s response to multiple prostate cancer therapies at once, with an implantable and retrievable device about the size of a grain of rice. Oliver Jonas, PhD, the inventor of the device, discusses its development and path to regulatory approval.


Some U.S. Labs Do Not Systematically Report Globozoospermia

Close up of microscope with petri dish for in vitro fertilization

In a nationwide survey sent to in vitro fertilization and andrology clinic laboratory directors, Brigham researchers identified a gap between the ability of U.S. laboratories to recognize globozoospermia, a rare cause of male factor infertility, and the extent to which they report it to the clinician.


New Brigham Center for Transgender Health Aims to Lead the Field

Progress pride flag on flagpole flying in sky

The Brigham has launched an academic center for the healthcare needs of transgender and gender-diverse people. Devin O’Brien-Coon, MD, MS, clinical director and surgical co-director, discusses the impetus for founding the Center for Transgender Health and what he expects its multidisciplinary team will accomplish.


New Tool Assists in the Evaluation of Abdominal Pain After Robotic-assisted Laparoscopic Prostatectomy

Close up of doctors' hands holding a laparoscopic instrument in surgical setting

The Brigham’s Venkat M. Ramakrishnan, MD, PhD, and colleagues are the first to systematically assess residual gas (RPP) with CT after laparoscopy. They presenta tableto help clinicians determine whether RPP at a particular time point after robotic-assisted laparoscopic prostatectomy (RALP) is in the expected range.


Inquire About Lower Urinary Tract Symptoms in Patients With Endometriosis

Woman sitting on bed and holding abdomen, suffering from endometriosis pain

In the first study of its kind, Iwona Gabriel, MD, PhD, and Vatche A. Minassian, MD, MPH, of the Urogynecology Group, and colleagues found women and adolescents with surgically confirmed endometriosis are at substantially greater risk than others of having multiple lower urinary tract symptoms.


Role of DNA Damage Response Genes in Prostate Cancer Similar for African Americans, European Americans

Representation of the <em>BRCA2</em> gene

Adam S. Kibel, MD, and Anna Plym, PhD, of the Division of Urology, and colleagues conducted the most comprehensive study to date on the role of inherited DNA damage response (DDR) genes in aggressive prostate cancer. They report high carrier frequency of DDR gene alterations in lethal cases irrespective of ancestry.