Endoscopic Gastric Plication Reduces Fibrosis in Patients With Obesity and NAFLD

Close up Doctor point out the computer screen, report of gastrointestinal endoscopy, medical imaging EGD looking for structures in the esophagus.Medical image concept.

Researchers at Brigham and Women’s Hospital have linked endoscopic gastric plication (also called distal primary obesity surgery endoluminal, or POSE) to significant improvement in liver-related outcomes in patients with obesity, nonalcoholic fatty liver disease, and clinically significant hepatic fibrosis.

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Clinical and Allergy Profiles of Eosinophilic Esophagitis Differ From GERD

Walter Chan, MD, PhD, of Brigham and Women’s Hospital, and colleagues have reported supporting evidence that proton pump inhibitor (PPI)–responsive eosinophilic esophagitis (EoE) is clinically similar to PPI-nonresponsive EoE and significantly different from erosive esophagitis.

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Durable Diabetes Remission More Likely After Bariatric Surgery Than Medical/Lifestyle Therapy

Team of surgeons in operating room

Few surgeons perform metabolic surgery for type 2 diabetes treatment, citing inadequate evidence, and for the same reason, many health insurance plans don’t cover it. Long-term supportive efficacy data from the largest randomized cohort has been published.

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Second-generation Transoral Incisionless Fundoplication Reduces Symptoms of Atypical GERD

A systematic review and meta-analysis by researchers at Brigham and Women’s Hospital indicates second-generation transoral incisionless fundoplication (TIF 2.0) is effective for atypical GERD (laryngopharyngeal reflux) and improves patient-centered outcomes.

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Multisystems Approach Identifies Environmental Chemicals That Promote Intestinal Inflammation

Researchers at Brigham and Women’s Hospital are using an integrated systems approach—a publicly available database, zebrafish chemical screens, machine learning and mouse models—to identify environmental chemicals that promote intestinal inflammation.

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Enhanced Recovery Pathway Boosting Postsurgical Outcomes in Peritoneal Metastasis Patients

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve clinical outcomes and prognosis in patients with peritoneal metastasis. However, it is associated with a significant complication rate and a long postsurgical recovery in the hospital.
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Updated Guidelines: Enhanced Recovery Protocols for Colon and Rectal Surgery

Patient in hospital bed with doctor holding their hand, recovery after surgery

The American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons published revised joint guidelines for developing enhanced recovery protocols for elective colon and rectal resection. Jennifer L. Irani, MD, at Brigham and Women’s Hospital, served as co–first author.

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Gastroenterology Fellowship Leaders Perceive Multiple Benefits of GI Hospitalists

Doctor standing next to patient recovering in bed at hospital, inpatient

Clinicians in the Department of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital and colleagues explored the prevalence and perceptions of the GI hospitalist model in academic GI departments across the United States. They report GI hospitalists are relatively common and geographically diverse.

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Transcriptional Profile Overlaps in PPI-Responsive and -Nonresponsive Eosinophilic Esophagitis

Esophagram or Barium swallow front view showing esophagus for diagnosis

Researchers at Brigham and Women’s Hospital hypothesized that differences in mucosal gene transcript expression might explain the differences in PPI treatment response. Instead, they found the transcriptional profiles in patients with PPI-responsive and -nonresponsive eosinophilic esophagitis are remarkably similar.

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