Latest Clinical & Research News
Specialty: Endocrinology
Endoscopists at Brigham and Women’s Hospital have conducted the first study in which plication endoscopic transoral gastric outlet reduction was combined with argon plasma coagulation to treat weight gain after Roux-en-Y gastric bypass.
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Researchers have shown that a novel molecular signature from a single blood sample can identify women at risk of preeclampsia months before presentation. They also report that molecular signatures accurately track gestational age, independently of clinical factors, and could advance the study of other complications.
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When the COVID-19 lockdown began, the Brigham’s Diabetes Management Program developed a protocol for reaching out to patients whose routine clinic visits were abruptly canceled. A study led by Marie E. McDonnell, MD, revealed two-way communication was necessary to re-engage patients in diabetes care after disruption.
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In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.
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Brianne A. Kent, PhD, Steven W. Lockley, PhD, and colleagues hypothesize that peripheral clocks exist in humans. They report that the circadian rhythms of certain peripheral metabolic markers—lipids and liver proteins—differ from that of melatonin, a principal marker of central pacemaker activity.
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The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.
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An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.
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In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.
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Since many patients with diabetes are ineligible for RYGB or decline it, researchers at Brigham and Women’s Hospital developed an orally administered gut barrier coating for improving glucose homeostasis.
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Researchers in the Brigham’s Division of Pharmacoepidemiology and Pharmacoeconomics, led by Elisabetta Patorno, MD, DrPH, have determined obesity-related International Classification of Disease (ICD) codes accurately identify patients with obesity in claims-based data.
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