Based on findings from a novel mouse model, researchers at Brigham and Women’s Hospital led by Ursula B. Kaiser, MD, suggest that genetic variants resulting in increased MKRN3 expression may be a previously unrecognized cause of delayed puberty.

Sylvia Kehlenbrink, MD, endocrinologist and director of Global Endocrinology at Brigham and Women’s Hospital, and colleagues outline challenges and possible solutions for providing diabetes care during acute and prolonged humanitarian crises.

Lead author Meryl S. LeBoff, MD, discusses the new Bone Health and Osteoporosis Foundation’s “Clinician’s Guide to Prevention and Treatment of Osteoporosis,” along with the urgency of enhancing the prevention, risk management, diagnosis, and treatment of osteoporosis in postmenopausal women and men aged 50+ years.

To address conflicting evidence, Meryl S. LeBoff, MD, JoAnn E. Manson, MD, PhD, MPH, and colleagues conducted an ancillary analysis of the Vitamin D and Omega-3 Trial (VITAL). They found vitamin D did not affect fracture risk in the general population.

Brigham researchers are looking at novel ways to boost natural mechanisms that the body uses to counteract the pathogenesis of obesity and its complications. An upcoming clinical trial led by Mehmet Furkan Burak, MD, explores the impact of dietary supplementation with palmitoleic acid in obese, prediabetic individuals.