Study Reveals Pathogenic Role of Eosinophils in Atherosclerosis

3d rendered medically accurate illustration of an eosinophil

A recent study co-led by Guo-Ping Shi, ScD, and Zhaojie Meng, PhD, of the Division of Cardiovascular Medicine at Brigham and Women’s Hospital, is the first to identify a receptor for eosinophil cationic protein and define its pathogenic role in atherosclerosis.


Transgenic Mouse Model Uncovers Connections Between Peripheral Nerves and the Heart

Researchers used an approach to generate oxidative stress in the vascular endothelium, planning to explore diseases such as hypertension and aortic aneurysms. Surprisingly, the transgenic mice developed neurodegeneration, mitochondrial dysfunction, and cardiac hypertrophy caused by neurovascular oxidative stress.


Safety and Tolerability of Semaglutide: Pooled Phase 3 Data

Close up of woman injecting insulin into stomach

Brigham and Women’s Hospital researchers report an integrated analysis of 18 randomized, controlled trials of semaglutide (17,639 patients), concluding its safety and tolerability are now well characterized—and similar for the subcutaneous and oral formulations.


Hyperkalemia During Renin–Angiotensin–Aldosterone System Inhibitor Therapy Linked To Poorer Outcomes

A photograph of a tall peak T type cardiac electrodes that can tell if a patient has Hyperkalemia.

Hyperkalemia is one of the most common adverse reactions to renin–angiotensin–aldosterone system inhibitor (RAASi) therapy. In a recent study, Brigham and Women’s Hospital researchers found that patients who develop hyperkalemia while receiving RAASi therapy have a higher risk of poor outcomes.


Inflammation Versus LDL Cholesterol As Predictor of CV Events in Patients Using Statins

Young female doctor consults with senior male patient at hospital, in front of laptop

A collaborative analysis of 31,245 participants in three recent randomized trials suggests residual inflammatory risk is more strongly associated with future cardiovascular events than residual cholesterol risk.


Centralized Protocol Improves Optimization of Guideline-Concordant Medical Therapy for HFrEF Patients Hospitalized for Any Reason

Doctor on laptop with stethoscope on table, electronic health record concept

A multicenter quality improvement study, IMPLEMENT-HF, shows that a centralized virtual team make suggestions to treating clinicians about caring for hospitalized patients with HFrEF improved the use of guideline-concordant medical therapy.


Applying Engineering Expertise to Enrich Diagnostics, Therapy Planning, and Decision-making

Virtual surgery through numerical simulation of thoracic endovascular aortic repair implantation

Farhad R. Nezami, PhD, lead investigator in the Division of Cardiac Surgery at Brigham and Women’s Hospital, is a mechanical and aerospace engineer by training. His lab pulls from engineering, computer science, and bioinformatics to uncover better diagnostic tools and predictors of clinical events.


Case Report: Hypertrophic Cardiomyopathy As an Unexpected Mimic of Inducible Laryngeal Obstruction

Close up of older man touching throat, discomfort, inducible laryngeal obstruction concept

Physicians at Brigham and Women’s Hospital recently encountered a patient with exertional dyspnea and inducible laryngeal obstruction at rest who was ultimately diagnosed with hypertrophic cardiomyopathy as the cause of his symptoms.


Economic Food Insecurity Tied to Greater Risk of Incident CHD and HFrEF

Word cloud

Rani Zierath, Amil Shah, MD, MPH, and colleagues have published a novel finding that economic food insecurity is a risk factor for new-onset coronary heart disease and new-onset heart failure with reduced ejection fraction.


Sonographic B-lines Facilitate Detection of Pulmonary Congestion After Acute MI

Doctor performs chest ultrasound on man in hospital closeup

Researchers at Brigham and Women’s Hospital are the first to study the long-term trajectory of lung ultrasound findings after acute myocardial infarction (AMI). They conclude that quantification of B-lines could facilitate early detection, quantification, and monitoring of pulmonary congestion in AMI patients.