A recent study co-led by Guo-Ping Shi, ScD, and Zhaojie Meng, PhD, of the Division of Cardiovascular Medicine at Brigham and Women’s Hospital, is the first to identify a receptor for eosinophil cationic protein and define its pathogenic role in atherosclerosis.

Researchers used an approach to generate oxidative stress in the vascular endothelium, planning to explore diseases such as hypertension and aortic aneurysms. Surprisingly, the transgenic mice developed neurodegeneration, mitochondrial dysfunction, and cardiac hypertrophy caused by neurovascular oxidative stress.

A collaborative analysis of 31,245 participants in three recent randomized trials suggests residual inflammatory risk is more strongly associated with future cardiovascular events than residual cholesterol risk.

A multicenter quality improvement study, IMPLEMENT-HF, shows that a centralized virtual team make suggestions to treating clinicians about caring for hospitalized patients with HFrEF improved the use of guideline-concordant medical therapy.

Rani Zierath, Amil Shah, MD, MPH, and colleagues have published a novel finding that economic food insecurity is a risk factor for new-onset coronary heart disease and new-onset heart failure with reduced ejection fraction.

Researchers at Brigham and Women’s Hospital are the first to study the long-term trajectory of lung ultrasound findings after acute myocardial infarction (AMI). They conclude that quantification of B-lines could facilitate early detection, quantification, and monitoring of pulmonary congestion in AMI patients.