Fundamental Differences Detected Between National Databases in Outcomes of OAAA Repair

Close up of abdominal surgery

Wide variability has been reported in the administrative and quality improvement databases that are used to guide evidence-based decision-making in vascular surgery. A Brigham team detected numerous differences in patient populations and outcomes between three national data repositories using OAAA repair as a model.


Frailty Status Predicts Mortality After In-hospital CPR

Hands of senior woman resting on cane handle

Ariela Orkaby MD, MPH, of the Brigham’s Division of Aging, and colleagues report that increased frailty status as rated on the Clinical Frailty Scale is associated with increased mortality in older adults after in-hospital cardiopulmonary resuscitation.


No Increased Risk of VTE With Tofacitinib vs. TNF Inhibitors in Routine Care

3D Rendering of Tofacitinib Drug Molecule

The Brigham’s Seoyoung C. Kim, MD, ScD, Michael E. Weinblatt, MD, Rishi J. Desai, PhD, and colleagues have analyzed new data that shows no increased risk of venous thromboembolism (VTE) in patients with rheumatoid arthritis who use tofacitinib.


Patients Receiving Implanted Devices Need Better Education About Device Documentation, Tracking

X-ray of a permanent pacemaker implant in the chest

A Brigham and Women’s Hospital team reports most patients were unaware of the availability of unique device identifiers for documentation and tracking of their device, and they mistrust having it shared outside the health care system.


Phase 2a Trial: Monoclonal Antibody Increases Quantity of Functional HDL in Patients With CAD

Color rendering of High-Density Lipoprotein (HDL) particles

Marc S. Sabatine, MD, MPH, and colleagues recently reported the results of LEGACY, a double-blind phase 2a trial of MEDI5884. They observed an increased quantity of functional HDL particles and no adverse safety signal.


New Edition of ‘Braunwald’s Heart Disease’ Has Strong Brigham Imprint

stethoscope on a textbook

Brigham cardiovascular specialist Peter Libby, MD, was editor-in-chief of the 12th edition of the iconic textbook “Braunwald’s Heart Disease”, released late last year. He discusses the process of curating a new edition as well as the continued involvement of the founding editor, the Brigham’s Eugene Braunwald, MD.


Meta-analysis: Effect of EPA vs. EPA+DHA Omega-3 Fatty Acids on Cardiovascular Outcomes

Deepak L. Bhatt, MD, MPH, of the Interventional Cardiovascular Program at Brigham, and colleagues, recently performed a systematic review and meta-analysis and report that prescription EPA treatment, and not EPA+DHA supplementation, is associated with reductions in cardiovascular mortality and related outcomes.


Cardiac Risk Substantially Lower with Enzalutamide Than Abiraterone

Using the world’s largest pharmacovigilance database, Eugene B. Cone, MD, Quoc-Dien Trinh, MD, and colleagues determined the risk of cardiac adverse events is increased substantially with abiraterone and not at all with enzalutamide.


Myocardial Blood Flow Reserve Is an Early Marker of Myocardial Decompensation in Patients with Aortic Stenosis

Echocardiography image doppler of aortic stenosis

Marcelo F. DiCarli, MD, of the Cardiovascular Imaging Program at the Brigham, and Wunan Zhou, MD, MPH, at the NIH, and colleagues report that impaired myocardial blood flow reserve is an early marker of adverse myocardial characteristics and can identify patients who might benefit from aortic valve replacement.


Morbidity and Mortality from Mitral Valve Surgery After TEER: First CUTTING-EDGE Data

Team of cardiologists perform transcatheter closure treatment

Tsuyoshi Kaneko, MD, of the Heart & Vascular Center at Brigham, served as the first author of the initial analysis of CUTTING-EDGE data. Two key findings are that 93% of patients required MV replacement and one-year cumulative mortality for the entire cohort was 24%.