Wide variability has been reported in the administrative and quality improvement databases that are used to guide evidence-based decision-making in vascular surgery. A Brigham team detected numerous differences in patient populations and outcomes between three national data repositories using OAAA repair as a model.

A Brigham and Women’s Hospital team reports most patients were unaware of the availability of unique device identifiers for documentation and tracking of their device, and they mistrust having it shared outside the health care system.

Marc S. Sabatine, MD, MPH, and colleagues recently reported the results of LEGACY, a double-blind phase 2a trial of MEDI5884. They observed an increased quantity of functional HDL particles and no adverse safety signal.

Brigham cardiovascular specialist Peter Libby, MD, was editor-in-chief of the 12th edition of the iconic textbook “Braunwald’s Heart Disease”, released late last year. He discusses the process of curating a new edition as well as the continued involvement of the founding editor, the Brigham’s Eugene Braunwald, MD.

Deepak L. Bhatt, MD, MPH, of the Interventional Cardiovascular Program at Brigham, and colleagues, recently performed a systematic review and meta-analysis and report that prescription EPA treatment, and not EPA+DHA supplementation, is associated with reductions in cardiovascular mortality and related outcomes.

Marcelo F. DiCarli, MD, of the Cardiovascular Imaging Program at the Brigham, and Wunan Zhou, MD, MPH, at the NIH, and colleagues report that impaired myocardial blood flow reserve is an early marker of adverse myocardial characteristics and can identify patients who might benefit from aortic valve replacement.

Tsuyoshi Kaneko, MD, of the Heart & Vascular Center at Brigham, served as the first author of the initial analysis of CUTTING-EDGE data. Two key findings are that 93% of patients required MV replacement and one-year cumulative mortality for the entire cohort was 24%.