Implant Survival After TKA at Age 40 or Younger Is Comparable to Rates in Older Adults

Department of Orthopaedic Surgery researchers at Brigham and Women’s Hospital and colleagues recently completed a retrospective study of patients who underwent total knee arthroplasty (TKA) at age 40 or younger. They report that 15-year revision-free implant survival was comparable to rates in studies of older adults.

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Centrally Distributed Adiposity Linked to Higher Risk of Fecal Incontinence

Brigham and Women’s Hospital researchers and colleagues hypothesized that central adiposity, not elevated BMI alone, may have a role in fecal incontinence (FI). They report that waist circumference-to-height ratio (WtHR) is a stronger predictor of FI than BMI.

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Lipidomics Team Receives Ammodo Science Award for Tuberculosis Research

A multi-institutional research group co-led by D. Branch Moody, MD, of Brigham and Women’s Hospital, received an Ammodo Science Award for their groundbreaking research on lipid molecules. Their goal is to develop effective diagnostic tests and vaccines against tuberculosis and other infectious diseases.

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Driving Innovation in Abdominal Wall Reconstruction

Throughout his career, new Brigham gastrointestinal surgeon O. Yusef Kudsi, MD, MBA, has embodied an entrepreneurial spirit most often seen in the business world. That characteristic helped him develop an international reputation as a hernia surgeon and a pioneer in robotic procedures for abdominal wall reconstruction.

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Noninvasive Prenatal Test Detects Fetal Antigens

Researchers have validated a next generation sequencing (NGS)-based noninvasive prenatal test that uses quantitative counting template technology to detect RhD, C, c, E, K (Kell), and Fya (Dufy) fetal antigengenotypes from maternal blood samples in the ethnically-diverse U.S. population.

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Certain Plasma Metabolites and Metabolite Classes Linked to Persistent Tinnitus

Mass General Brigham researchers recently completed the first human study that examined links between metabolites and persistent tinnitus. They say metabolomic profiling is a promising approach to pinpointing tinnitus biomarkers and should provide valuable insights into the pathophysiology of the disorder.

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Immunoprofiling Can Identify Immune Cell Abnormalities, Guide Care for Patients With Unusual Inflammatory Disease Presentations

Histology of skin human tissue , show epithelium tissue and connective tissue with microscope view

Alisa Mueller, MD, PhD, Takanori Sasaki, MD, PhD, Deepak Rao, MD, PhD, and colleagues have demonstrated that for patients with unusual autoimmune or inflammatory conditions, cellular and transcriptomic immunophenotyping can serve as complementary diagnostic tools and guide treatment decisions.

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Heart Rhythm 2024: Brigham Presents Electrophysiology Research

On May 16 – 19, 2024, faculty from the Heart & Vascular Center at Brigham and Women’s Hospital will join the international electrophysiology community and present their latest research at the Heart Rhythm 2024 annual meeting.

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Bariatric Surgery Provides Long-Term Blood Glucose Control in Patients With Type 2 Diabetes

A recent pooled analysis of randomized trials co-led by Brigham and Women’s Hospital researchers indicates that patients with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to patients who received medical management plus lifestyle interventions.

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Pushing the Boundaries of Research and Clinical Care in Pancreatic Cancer

From novel laboratory research that enables scientists to define pancreatic cancer cells better to new clinical approaches that expedite postsurgical recovery, Dana-Farber Brigham Cancer Center is steadily advancing the diagnosis and management of pancreatic cancers. Sahar Nissim, MD, PhD, and Thomas E. Clancy, MD, FACS, elaborate.

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