Review: Diagnostic Approach to Lower Gastrointestinal Bleeding

Surgeons holding endoscopic tools preparing for gastrointestinal evaluation

Daniel J. Stein, MD, MPH, in the Department of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital, Joseph D. Feuerstein, MD, and a colleague recently reviewed for hospitalists the first-line diagnostic and treatment options when acute lower gastrointestinal bleeding is suspected.


Survey of Preeclampsia Survivors Reveals Need for Better Patient Education, Postpartum Counseling

Doctor shows information on clipboard to pregnant patient seated on table

Ellen W. Seely, MD, and colleagues used a structured survey to ascertain the experience of preeclampsia from the patient’s point of view. The responses demonstrate a need for routine, thorough patient education about preeclampsia early in pregnancy, as well as better postpartum care.


Large-scale Collaborative Network Valuable for Research in Bipolar Disorder

Over the shoulder view of female psychiatrist writing on clipboard speaking with male patient

To examine the value of large-scale collaboration, researchers at Brigham and Women’s Hospital and colleagues worldwide recently determined core predictors of functional outcome in bipolar disorder, independent of treatment organization or societal differences.


Work Relative Value Units Correlate Well With Mean Operative Time in Multiple Specialties

Close up of three medical professionals operating on patient

Surgeons commonly voice the opinion that work relative value units (wRVUs) do not accurately quantify surgeon workload or determine appropriate reimbursement. Brigham researchers investigated and found wRVUs correlate well with mean operative time for the most common surgical procedures across various specialties.


Dupilumab Use Associated With Increased IL-4 and IL-18 Production

Asian woman pinches her brow, highlighted red for concept of rhinosinusitis pain

Stella E. Lee, MD, of the Division of Otolaryngology–Head & Neck Surgery at Brigham and Women’s Hospital, and colleagues speculate that global IL-4Rα inhibition could have immune consequences. In a research note, they report preliminary data on how targeting IL-4Rα with dupilumab changes the local inflammatory milieu.


New Tool Allows Early Prediction of Disease Course in Multiple Sclerosis

Rendering of orange microglia cells damaging the myelin sheath of neuron axons

Using machine learning, researchers in the Brigham Multiple Sclerosis Center and colleagues have developed a tool for predicting what the outcome of patients with recently diagnosed MS will be in 10 years.


Video Decision Aids Plus Remote Clinician Training Improved Advance Care Planning During COVID-19

Doctor on video call with older female patient

The need for advance care planning (ACP) was especially heightened for older, Black, and Latino/a/x patients at the onset of the COVID-19 pandemic. Brigham researchers tested an ACP intervention with video decision aids and remote clinician training, reporting improved ACP documentation rapidly and efficiently.


Women, People With Low Incomes Still Have Worse Outcomes After Cardiac Surgery

Close up of female patient lying on hospital bed with ID bracelet, recovering from surgery

Over the past decade in cardiac surgery, health policy initiatives have been implemented to reduce sex and socioeconomic status disparities. To evaluate progress in the U.S., researchers at Brigham and Women’s Hospital recently conducted the largest nationally representative study to date.


Women With IBD Are Vulnerable to Postpartum Infections

Close up of woman holding newborn infant in hospital after giving birth

Brigham and Women’s Hospital conducted the first study that examined a wide spectrum of infectious complications and included a non-IBD control group. They report a higher risk of postpartum infections in women with IBD regardless of the mode of delivery.


New Tool Predicts Success of Direct Endoscopic Necrosectomy With LAMS for Pancreatic Walled-Off Necrosis

Rendering of blue human body concept with pancreas highlighted in red

Marvin Ryou, MD, director of endoscopic innovation, and Christopher C. Thompson, MD, MSc, director of endoscopy, recently conducted the first study of which patients are most likely to respond to direct endoscopic necrosectomy with lumen-apposing metal stent (LAMS) for pancreatic walled-off necrosis.