Review: Diagnosis and Management of Lumbar Spinal Stenosis

Female clinician physical therapist working on spine of male patient

Brigham and Women’s Hospital’s Jeffrey N. Katz, MD, MS, of the Orthopaedic and Arthritis Center for Outcomes Research, Melvin C. Makhni, MD, of the Department of Orthopaedic Surgery, and colleagues review the current evidence about managing acquired, degenerative lumbar spinal stenosis (LSS).

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“Off-the-Shelf” Engineered Stem Cell Therapy for Glioblastoma Prolongs Survival in Animal Model

Glioblastoma brain cancer cells under microscope

Researchers at Brigham and Women’s Hospital have designed a biologic agent, dubbed EnMSCBif, to bind to death receptor 5 (DR5) on the surface of glioblastoma cells and trigger extrinsic programmed cell death. They report on the high potential of EnMSCBif to be translated into clinical use.

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Consensus Report: Appropriate Use of Telemedicine in Spine Surgery

Over the shoulder of doctor speaking to patient via video chat on laptop, taking notes on clipboard

The Telemedicine Working Group of AO Spine, a global academic community, convened an expert panel to attempt to reach a consensus on practical aspects of telemedicine related to spine care. Melvin C. Makhni, MD, in the Department of Orthopaedic Surgery, served as senior author of the report.

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Novel Low-Cost and Disposable GI Manometry Devices to Broaden Use in Low-Resource Settings

Standard digital manometer for GI diagnosis.

Working with scientists at MIT, Brigham and Women’s Hospital researchers have developed a much simpler alternative to GI manometers called quipu-inspired, liquid metal–enabled pressure transducers (QUILT).

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Atlas of Migraine Cell Types Expected to Lead to Better Treatments

Migraine and related headache disorders activate peripheral sensory neurons in the trigeminal ganglion (TG). Researchers at Brigham and Women’s Hospital have now mapped the TG cell types in both humans and mice and the genes they express.

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Novel POSE Techniques Developed at the Brigham Are Safe and Effective

Close up of doctor holding endoscopic examination tool before surgery

In 2018, Pichamol Jirapinyo, MD, MPH, and Christopher C. Thompson, MD, developed a modified technique they call distal POSE—which involves placing plications primarily in the gastric body, sparing the fundus. They have published a one-year study, concluding distal POSE appears safe and effective for treating obesity.

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Treatment Persistence Greater With First-line Vedolizumab Than TNFα Inhibitors for Ulcerative Colitis

Rendering of digestive system with inflammed large intestine from ulcerative colitis

The only head-to-head trial that compared biologics for treating ulcerative colitis (UC) found superiority of vedolizumab to adalimumab for clinical remission. Now, a retrospective study shows that biologic-naïve adults with UC stay on vedolizumab longer than either of the two tumor necrosis factor-α (TNFα) inhibitors.

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Pre-TKA Expectations About Pain, Functional Limitation Influence One-Year Outcomes

X-ray of total knee arthroplasty, highlighted in red

Robert R. Edwards, PhD, and colleagues explored the impact of expectancies on outcomes at three time points after total knee arthroplasty. They report that presurgical expectancies about pain reduction and functional improvement significantly predicted those outcomes only at the one-year follow-up.

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Extended Use of Apixaban Tied to Reduced Risk of Hospitalization for Recurrent VTE

3D structure of apixaban on white background

Researchers at Brigham and Women’s Hospital recently published a nationwide U.S. study of patients who received more than 90 days of oral anticoagulation after hospitalization for VTE. They found dispensing of apixaban, versus warfarin, was associated with a modestly lower hospitalization rate for recurrent VTE.

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Brigham Leaders Present at PAS 2022

Over the shoulder view of woman standing at a podium with laptop, presenting to a seated audience

Leaders from the Brigham’s Department of Pediatric Newborn Medicine presented their latest research to thousands of attendees at the 2022 Pediatric Academic Societies’ meeting. The department had a strong presence at this event, which took place April 21 – 25, 2022, in Denver, CO.

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