Remote Physician Visits for Hospital-level Care at Home Generally Noninferior to In-Home Visits

Female patient speaking to doctor via virtual telehealth appointment on laptop

David M. Levine, MD, MPH, MA, and Jeffrey L. Schnipper, MD, MPH, of the Division of General Internal Medicine & Primary Care, and colleagues found patients who received predominantly remote physician care via videoconference had a noninferior number of adverse events compared with those who had only in-home care.


Novel Approach Protects Animal Model Against Bacterial Pneumonia After Influenza A Infection

3D rendering of human lung anatomy, showing rod-shaped bacteria inside lung aveoli

Brigham researchers believe a new host-directed treatment approach to secondary bacterial pneumonia, a serious and common complication of infection with the influenza A virus (IAV) that can also occur after SARS-CoV-2 infection, might complement antibiotic therapy.


Brigham-Spaulding Collaborative Enhances Care of Complex Thoracic Surgical Patients in Rehab

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The Brigham’s Division of Thoracic Surgery launched a care continuum collaborative in 2011 to monitor the progress of patients discharged to Spaulding Rehabilitation Hospital after thoracic surgery. Namrata Patil, MD, MPH, details why she founded the collaboration and its beneficial impact on patient care.


Perioperative Use of Pain Medications Similar for Vaginal and Laparoscopic Repair of Pelvic Organ Prolapse

Female patient in hospital bed recovering after surgery, holding mug and looking out bright window

Minimally invasive surgery is often promoted as a way to reduce postoperative pain after benign gynecological surgery. However, Brigham researchers found vaginal and laparoscopic hysterectomy for treatment of pelvic organ prolapse appear to be similar with regard to postoperative pain medication requirements.


Sleep Discontinuity in Perimenopausal Women Linked to Female Reproductive Hormone Patterns

Woman in bed covering face, unable to sleep. Alarm clock on bed reads 3:41

The Brigham’s Jamie Coborn, PhD, Hadine Joffe, MD, and colleagues have published empirical evidence that changing hormone dynamics underlie awakenings in perimenopausal women, independent of vasomotor symptoms.


Cognitive Deficits Present Across Domains in Schizophrenia and Relate to Positive Symptoms

Young woman on couch, emotional, talking with female researcher or doctor who holds a clipboard

Johanna Seitz-Holland, PhD, Marek Kubicki, MD, PhD, of the Department of Psychiatry at the Brigham, and colleagues recently became the first to investigate cognitive deficits in schizophrenia in a large-scale, thoroughly harmonized sample.


Brigham Hosts Country’s First High-Resolution Anoscopy Course for Colorectal Surgery Fellows

Five researchers standing in a line inside a lab smiling at camera

High-resolution anoscopy can be a helpful tool for identifying precancerous lesions in the anal canal. Colon and rectal surgeon James Yoo, MD, and infectious disease specialist Jennifer A. Johnson, MD, both of the Brigham, developed and recently hosted a course to educate colorectal fellows on the technique.


Penetrating the Blood-Brain Barrier to Improve Efficiency of Gene Therapy Delivery

3D illustration of adeno-associated viruses, used in gene cell therapy

The Brigham’s Fengfeng Bei, PhD, and team have reported on a new adeno-associated virus variant that delivers gene therapy across the blood-brain barrier in non-human primates more efficiently than previously developed vehicles. It could have implications for treating neurodegenerative diseases including Alzheimer’s.


Proteomics Data Suggest Diagnostic, Therapeutic Targets for RA Patients With Interstitial Lung Disease

Doctor examing ct scan images of lungs at desk, lung disease concept

Brigham researchers recently completed the first proteomic analysis in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD). They identify molecular signatures strongly associated with the presence and severity of RA-ILD and provide insight into unexplored disease pathways.


Vitamin D Supplementation Does Not Influence Fracture Risk in the General Population

Hand holding a vitamin d supplement pill up to the sky, with bright sun

To address conflicting evidence, Meryl S. LeBoff, MD, JoAnn E. Manson, MD, PhD, MPH, and colleagues conducted an ancillary analysis of the Vitamin D and Omega-3 Trial (VITAL). They found vitamin D did not affect fracture risk in the general population.