Biologic Therapies Shifting the Paradigm for Treating Chronic Rhinosinusitis

CT scan of patient after dupilumab treatment for chronic rhinosinusitis

For years, patients with chronic rhinosinusitis (CRS) and nasal polyps had few treatment options beyond topical corticosteroids and surgery. Stella Lee, MD, director of the Brigham Sinus Center, conducted trials of three biologic therapies showing signs of addressing CRS symptoms and improving patient quality of life.


Angled Fiber Tips Improve Anatomic Access in Models of In-Office Laser Treatment of the Larynx

3D rendering of larynx anatomy in throat of human being, highlighted orange

In two high-definition larynx models, Chan and colleagues recently demonstrated that side-firing laser fibers may substantially increase endoscopic access to difficult lesions. Now, researchers at Brigham and Women’s Hospital have built on that work, corroborating the results in additional, more varied anatomic models.


Delphi Process Determines Best Practices for Laryngopharyngeal Reflux Disease Treatment

Woman standing holding chest highlighted in red for laryngopharyngeal reflux disease discomfort

Thomas L. Carroll, MD, section chief of Laryngology and director of the Voice Program at Brigham and Women’s Hospital, and colleagues recently completed a Delphi process to develop guidance about treating laryngopharyngeal reflux disease (LPR). They report their consensus.


VESPA Scale Identifies Head and Neck Surgical Patients at Risk for Delayed or Complex Discharge

Empty hospital bed for recovery after surgery with heart monitor, wheelchair

Ashley L. Miller, MD, a resident in the Division of Otolaryngology–Head and Neck Surgery at Brigham and Women’s Hospital, and colleagues demonstrated that VESPA can identify patients scheduled for major otolaryngologic head and neck surgery who are at risk of delayed or complex discharge.


Frequent Use of Over-the-Counter Analgesics Linked to Persistent Tinnitus

Rendering of blue head with red radiating from ear, tinnitus concept

Researchers at Brigham and Women’s Hospital have determined aspirin and other over-the-counter analgesics are associated with the risk of persistent tinnitus, although the direction and magnitude differ for individual agents.


Dupilumab Use Associated With Increased IL-4 and IL-18 Production

Asian woman pinches her brow, highlighted red for concept of rhinosinusitis pain

Stella E. Lee, MD, of the Division of Otolaryngology–Head & Neck Surgery at Brigham and Women’s Hospital, and colleagues speculate that global IL-4Rα inhibition could have immune consequences. In a research note, they report preliminary data on how targeting IL-4Rα with dupilumab changes the local inflammatory milieu.


Menopausal Hormone Therapy Linked to Increased Risk of Pituitary Adenoma

Woman sitting down holding a pack of menopausal hormone therapy pills

David J. Cote, MD, PhD, and Meir J. Stampfer, MD, DrPH, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, and colleagues have conducted the first prospective study of associations between pituitary adenoma and the use of oral contraceptives or menopausal hormone therapy.


Socioeconomic Disparities Evident in Access to Ambulatory Otolaryngologic Surgery

Male patient in hospital bed recovering

A new study of otolaryngologic procedures by Shekhar K. Gadkaree, MD, Regan W. Bergmark, MD, and colleagues shows socioeconomic factors—including race/ethnicity and type of insurance—are associated with surgical settings independent of comorbidity status.


Respiratory Tract Diseases May Increase Risk of RA Years Before Onset

Close up of hands affected by rheumatoid arthritis

There is growing evidence that rheumatoid arthritis (RA) originates in mucosal surfaces and several respiratory tract diseases are associated with RA. Now, researchers have demonstrated that the timing of respiratory tract disease significantly affects the strength of each disease’s association with RA.


Cranial Nerve Imaging Abnormalities in Patients With Hereditary Neuropathies Can Mimic Otolaryngologic Problems

Doctor points to brain scan images to detect abnormalities

C. Eduardo Corrales, MD, Ryan A. Bartholomew, MD, and colleagues detected a 21% prevalence of radiologic cranial nerves abnormalities in patients with hereditary neuropathies who underwent MRI. They caution physicians not to assume these findings represent pathologies requiring intervention by an otolaryngologist.