Dapagliflozin Efficacious, Safe in Type 2 Diabetes Regardless of Pre-Treatment Systolic BP

Close up of blood pressure monitor screen reading 100 over 156

SGLT2 inhibitors like dapagliflozin reduce hospitalization for heart failure and progression of diabetic nephropathy in patients with type 2 diabetes, but decrease systolic and diastolic blood pressure only minimally. Brigham researchers investigated whether their efficacy might depend on pre-treatment blood pressure.


Frequent Use of Over-the-Counter Analgesics Linked to Persistent Tinnitus

Rendering of blue head with red radiating from ear, tinnitus concept

Researchers at Brigham and Women’s Hospital have determined aspirin and other over-the-counter analgesics are associated with the risk of persistent tinnitus, although the direction and magnitude differ for individual agents.


Mepivacaine Has Advantages Over Bupivacaine for Outpatient Total Joint Arthroplasty

Close up of vertical scar on knee and a bandaged knee after Total Knee Arthroplasty

Antonia F. Chen, MD, MBA, of the Department of Orthopaedic Surgery at the Brigham, Ahmed Siddiqi, DO, MBA, of the Orthopedic Institute of Central Jersey, and colleagues performed a systematic review and meta-analysis comparing bupivacaine with a shorter-acting spinal anesthetic, mepivacaine, during elective TJA.


Review: Diagnostic Approach to Lower Gastrointestinal Bleeding

Surgeons holding endoscopic tools preparing for gastrointestinal evaluation

Daniel J. Stein, MD, MPH, in the Department of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital, Joseph D. Feuerstein, MD, and a colleague recently reviewed for hospitalists the first-line diagnostic and treatment options when acute lower gastrointestinal bleeding is suspected.


Survey of Preeclampsia Survivors Reveals Need for Better Patient Education, Postpartum Counseling

Doctor shows information on clipboard to pregnant patient seated on table

Ellen W. Seely, MD, and colleagues used a structured survey to ascertain the experience of preeclampsia from the patient’s point of view. The responses demonstrate a need for routine, thorough patient education about preeclampsia early in pregnancy, as well as better postpartum care.


Large-scale Collaborative Network Valuable for Research in Bipolar Disorder

Over the shoulder view of female psychiatrist writing on clipboard speaking with male patient

To examine the value of large-scale collaboration, researchers at Brigham and Women’s Hospital and colleagues worldwide recently determined core predictors of functional outcome in bipolar disorder, independent of treatment organization or societal differences.


Work Relative Value Units Correlate Well With Mean Operative Time in Multiple Specialties

Close up of three medical professionals operating on patient

Surgeons commonly voice the opinion that work relative value units (wRVUs) do not accurately quantify surgeon workload or determine appropriate reimbursement. Brigham researchers investigated and found wRVUs correlate well with mean operative time for the most common surgical procedures across various specialties.


Dupilumab Use Associated With Increased IL-4 and IL-18 Production

Asian woman pinches her brow, highlighted red for concept of rhinosinusitis pain

Stella E. Lee, MD, of the Division of Otolaryngology–Head & Neck Surgery at Brigham and Women’s Hospital, and colleagues speculate that global IL-4Rα inhibition could have immune consequences. In a research note, they report preliminary data on how targeting IL-4Rα with dupilumab changes the local inflammatory milieu.


New Tool Allows Early Prediction of Disease Course in Multiple Sclerosis

Rendering of orange microglia cells damaging the myelin sheath of neuron axons

Using machine learning, researchers in the Brigham Multiple Sclerosis Center and colleagues have developed a tool for predicting what the outcome of patients with recently diagnosed MS will be in 10 years.


Video Decision Aids Plus Remote Clinician Training Improved Advance Care Planning During COVID-19

Doctor on video call with older female patient

The need for advance care planning (ACP) was especially heightened for older, Black, and Latino/a/x patients at the onset of the COVID-19 pandemic. Brigham researchers tested an ACP intervention with video decision aids and remote clinician training, reporting improved ACP documentation rapidly and efficiently.