Latest Clinical & Research News
Various demyelinating diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis (ADEM), and cerebral cortical encephalitis, are now recognized as a spectrum of diseases associated with high titers of autoantibodies that target myelin oligodendrocyte glycoprotein (MOG).
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Brigham and Women’s Hospital researchers recently conducted the first study of patient-reported data on the economic burden of neuromyelitis optica spectrum disorders (NMOSD). Specifically, they characterized the direct and indirect costs of relapse events (ED visits and hospitalizations).
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Brigham and Women’s Hospital recently determined how epithelial cells promote Th17 cell generation in response to bacterial colonization as a step toward better understanding the treatment—and even prevention—of chronic inflammatory diseases.
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On April 22–27, 2023, the American Academy of Neurology hosts its 75th annual meeting in Boston, MA and virtually. Leaders from the Department of Neurology at Brigham and Women’s Hospital will present their latest research at the meeting alongside international colleagues.
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Researchers at Brigham and Women’s Hospital recently demonstrated that lesions causing depression in patients with stroke or penetrating head trauma were functionally connected to a common brain circuit.
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Members of the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital presented over 120 lectures and poster presentations at the 2022 American College of Rheumatology’s annual convergence conference. Learn more about a few of their cutting-edge presentations.
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Giovanna S. Manzano, MD, of the Department of Neurology at Brigham and Women’s Hospital, Marcelo Matiello, MD, of Massachusetts General Hospital, and colleagues determined positive predictive values of a live cell–based serum assay that detects the diagnostic biomarker for MOG-AD in a real-world cohort.
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A groundbreaking intranasal vaccine for Alzheimer’s disease (AD) developed at Brigham shows tremendous promise in its first phase of human trials. Study leader Howard L. Weiner, MD, discusses the trial’s progress to date, planned future phases, and how the vaccine could shape the future of AD care.
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Obesity is linked to an increased risk of many diseases, but much remains unknown about the molecular mechanisms underlying this connection. In a new study from Brigham and Women’s Hospital and Harvard Medical School, investigators have found an unexpected role for cholesterol and its effects on the immune system in driving some of these obesity-linked diseases — in particular, with conditions characterized by autoimmunity.
From 7T MRI performed at Brigham and Women’s Hospital in Study Patient 1. This is a T2* gradient-echo sequence (0.8 mm isotropic voxels) showing a typical MS lesion (arrow) as oval, and bright, containing a central (dark) vessel.
During the COVID-19 pandemic, patients with multiple sclerosis (MS) and their clinicians have had questions and concerns about whether immunotherapies for MS could influence risk for infection or lead to an unfavorable outcome.