Latest Clinical & Research News
Researchers from the Brigham, the Broad Institute, and Stanford Medicine combined multiple sequencing and experimental techniques to map the relationship between known coronary artery disease (CAD) variants and the biological pathways they impact.
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Teams across Brigham and Women’s Hospital have been working to elevate the quality and safety of geriatric surgical care for over a decade. Now, the Brigham has become the first hospital of its size nationwide to achieve Geriatric Surgery Verification (GSV) from the American College of Surgeons (ACS).
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C. Eduardo Corrales, MD, at Brigham and Women’s Hospital, Nir Ben-Shlomo, MD, of the University of Iowa Hospitals and Clinics, and colleagues recently undertook two related studies and present suggestions for avoiding iatrogenic inner ear dehiscence (IED) complications after surgery.
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Obstetrician Louise Wilkins-Haug, MD, PhD, and endocrinologist Ellen Seely, MD, are leaders at the Brigham’s Center for Connected Postpartum Care. The pair discusses the need for this center, its multidisciplinary approach to care, and its early successes in managing hypertensive patients postpartum.
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Brigham gynecologist and clinical oncologist Naoko Sasamoto, MD, PhD, MPH, is focused on developing novel therapeutics that target the underlying causes of endometriosis, a disease that affects up to 10% of women of reproductive age and causes pelvic pain that can severely impact a patient’s quality of life.
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Brigham researchers are challenging the trend of deprescribing statins in people over 75 years of age. Ariela Orkaby, MD, MPH, led a trio of studies of statin use in older adults with chronic kidney disease, older adults with and without frailty, and adults with heart failure with preserved ejection fraction.
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Brigham researchers suggest modafinil may have a positive impact on neurocognitive functioning and possibly daytime sleepiness, but it may also have a negative effect on sleep quality.
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Meet Anthony D’Amico, MD, PhD, Chief of Genitourinary Radiation Oncology at Dana-Farber Brigham Cancer Center, and Eleanor Theresa Walters Distinguished Chair in Radiation Oncology, renowned for his exceptional contributions to cancer care, particularly in genitourinary cancer.
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A recent retrospective, multicenter cohort study suggests osimertinib is more likely to benefit non-small cell lung cancer patients with EGFR mutations than alternative approaches, though prospective clinical trials are needed to confirm the findings. The Brigham’s Elio Adib, MD, a co-author of the study, discusses key takeaways.
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Mutations in human presenilin genes (PSEN1 and PSEN2) are the major cause of early-onset familial Alzheimer’s disease (FAD). Building on the previous work, Brigham reserachers have published preclinical evidence that using gene therapy to deliver a functional copy of PSEN1 may someday be able to treat FAD.
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