Latest Clinical & Research News
Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.
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Researchers at the Brigham have demonstrated that mice with ovarian failure caused by chemotherapy can have their fertility restored using induced pluripotent stem cells (iPSCs). Not only were the mice able to make functional eggs from the iPSCs, but those eggs developed into pups that were able to reproduce.
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Researchers used an approach to generate oxidative stress in the vascular endothelium, planning to explore diseases such as hypertension and aortic aneurysms. Surprisingly, the transgenic mice developed neurodegeneration, mitochondrial dysfunction, and cardiac hypertrophy caused by neurovascular oxidative stress.
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Brigham orthopedist Christian Lattermann, MD, was the principal investigator of a study examining a possible connection between dysregulated inflammatory response and effusion synovitis after an ACL injury. He says risk stratification may help clinicians determine the appropriate treatment approach for each patient.
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Brigham and Women’s Hospital researchers constructed a computer model for financial decision analysis of surgical approaches to testicular sperm extraction, which most U.S. residents must pay for out-of-pocket but is the only option for men with non-obstructive azoospermia who want to conceive a biological child.
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In a retrospective real-world study, Brigham and Women’s Hospital researchers demonstrated that tofacitinib and ustekinumab are equally effective for achieving steroid-free clinical remission of ulcerative colitis at 12 and 52 weeks.
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U.S. News & World Report 2023-24 ranks Brigham and Women’s Hospital #1 in the nation for Obstetrics and Gynecology for the second consecutive year. Department Chair Nawal Nour, MD, MPH, celebrates this major accomplishment by reflecting on the team’s commitment to providing comprehensive, equitable OB/GYN care.
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A study led by Brigham and Women’s Hospital researchers suggests occupational factors are linked to male fertility. Men who reported more physical activity at work had higher sperm concentrations and testosterone levels.
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In this video recorded by Healio at the American Academy of Orthopaedic Surgeons Annual Meeting, Richard Iorio, MD, FAAOS, spoke about the state of physical therapy after total joint replacement.
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Brigham and Women’s Hospital researchers, and colleagues investigated the effect of combining pharmacotherapy with transoral outlet reduction. They demonstrate the combination is superior to either therapy alone and provides similar efficacy to surgical revision for weight gain after Roux-en-Y gastric bypass.
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