Analgesics for IBD Most Often Prescribed to Patients With Older Adult–Onset

Rahul S. Dalal, MD, MPH, at Brigham and Women’s Hospital, and colleagues recently completed a nationwide study of the use of analgesics for IBD according to age at disease onset. They report individuals with older adult–onset of IBD were more commonly prescribed analgesic medications, compared with other age groups.

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Case Report: Recurrent Intraventricular Hemorrhage in Cerebral Proliferative Angiopathy With Very Long-term Follow-up

Cerebral proliferative angiopathy (CPA) is a cerebral vascular malformation with distinctive features. Brigham and Women’s Hospital researchers present one of the few reports of long-term follow-up of a patient with hemorrhage in CPA: 32 years of data on a patient who had recurrent hemorrhage.

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Study Shows Semaglutide Reduces Cardiovascular Events in People With Overweight or Obesity but Not Diabetes

The Brigham was part of a trial that shows for the first time that the weight loss drug semaglutide lowers the incidence of death from cardiovascular causes in those with overweight or obesity but not diabetes. Jorge Plutzky, MD, discusses the findings and implications for clinical care.

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Inflammation At Least As Important As Cholesterol for Predicting CV Risk in Statin-intolerant Patients

Paul M. Ridker, MD, MPH, of the Center for Cardiovascular Disease Prevention at Brigham and Women’s Hospital, and colleagues found inflammation assessed by hsCRP predicted cardiovascular events and death at least as strongly as LDLC when comparing bempedoic acid with placebo in statin-intolerant patients.

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Artificial Intelligence, Machine Learning, and the Future of Neurosurgical Care

Timothy Smith, MD, PhD, MPH, a neurosurgeon-scientist in the Brigham’s Department of Neurosurgery, is exploring how to utilize artificial intelligence and machine learning to optimize neurosurgical patient care. He is co-author of three papers that offer a glimpse into how these technologies are transforming the field.

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AI Model Detects Atrial Septal Defects From Electrocardiograms

Shinichi Goto, PhD, at Brigham and Women’s Hospital, and colleagues have developed a deep learning–based model that detects subtle changes in standard 12-lead electrocardiography data to flag patients who should undergo echocardiography to evaluate possible atrial septal defect.

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Neuroimaging Abnormalities Across Substance Use Disorders Map to a Common Brain Network

Researchers have found that multiple substance use disorders (SUDs) map to their own common brain network, a finding that has therapeutic implications of its own.

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Gene Therapy Approach Shows Encouraging Survival Results in Some Patients With Glioblastoma

In a first-in-human, phase 1 trial, Brigham researchers sought to address challenges associated with treating glioblastoma multiforme by using an injected, engineered oncolytic virus that activated immune cells in the tumor. E. Antonio Chiocca, MD, PhD, senior author of the paper, recently presented the study findings.

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Long-term Symptom Severity, Quality of Life Comparable Across Uterine-sparing Procedures for Fibroids

Brigham researchers report long-term outcomes of COMPARE-UF, a study of women who underwent procedural treatment of uterine fibroids. They say symptom severity and quality of life were comparable with surgical and nonsurgical uterine-sparing procedures, but only hysterectomy patients showed sustained relief at year 3.

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Ketamine Is Noninferior to ECT for Nonpsychotic Treatment-resistant Major Depression

Amit Anand, MD, director of Psychiatry Translational Clinical Trials at Brigham and Women’s Hospital, conducted ELEKT-D, a pragmatic comparative-effectiveness trial of ketamine and ECT for nonpsychotic treatment-resistant major depression.

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