Brigham Researchers Take a Closer Look at Lithium’s Effects on the Brain

Close up of a pile of pink lithium tablets with "223" imprinted on one side

Through brain imaging and laboratory research, Brigham investigators are examining how lithium affects the brain at the individual neuron and brain-circuit levels. Psychiatrist Amit Anand, MD, explains how it may increase the growth of certain areas of the brain and influence the organ functionally and structurally.


New Brigham Center for Transgender Health Aims to Lead the Field

Progress pride flag on flagpole flying in sky

The Brigham has launched an academic center for the healthcare needs of transgender and gender-diverse people. Devin O’Brien-Coon, MD, MS, clinical director and surgical co-director, discusses the impetus for founding the Center for Transgender Health and what he expects its multidisciplinary team will accomplish.


New Tool Assists in the Evaluation of Abdominal Pain After Robotic-assisted Laparoscopic Prostatectomy

Close up of doctors' hands holding a laparoscopic instrument in surgical setting

The Brigham’s Venkat M. Ramakrishnan, MD, PhD, and colleagues are the first to systematically assess residual gas (RPP) with CT after laparoscopy. They presenta tableto help clinicians determine whether RPP at a particular time point after robotic-assisted laparoscopic prostatectomy (RALP) is in the expected range.


The Prevention Sweet Spot: Optimizing Treatment for Type 2 Diabetes

A group of colleagues standing together at a conference

Vanita Aroda, MD, associate physician in the Division of Endocrinology, Diabetes and Hypertension, has served as a clinical researcher and clinical trialist for countless studies focused on preventing and treating type 2 diabetes. She discusses her involvement in the SELECT, PIONEER 1, REVITALIZE 1, and other trials.


Flipping the Tubercle for Knee Cartilage Repair Increases Risk of Arthrofibrosis

Color rendering of a human knee joint on black background

Gergo Merkely, MD, and colleagues wondered whether extensive trauma and greater traction on the patella tendon might induce an inflammatory response that increases the risk of postoperative stiffness. They report evidence that, indeed, TTO-HD is an independent risk factor for postoperative arthrofibrosis.


Dronedarone Safely Treats Concomitant AF and HF With Preserved or Mildly Reduced Ejection Fraction

ECG with supraventricular extrasystole and short paroxysm of atrial fibrillation

A post hoc analysis of the ATHENA trial has determined that dronedarone has benefits in patients whose atrial fibrillation or atrial flutter is complicated by heart failure with preserved ejection fraction or heart failure with mildly reduced ejection fraction.


Novel Therapeutic Target Identified for Multiple Sclerosis

Blue 3D rendering of microRNA strands

Researchers at the Ann Romney Center for Neurologic Diseases at the Brigham, and colleagues have affirmed miR-92a as a powerful, clinically relevant target in multiple sclerosis and give preliminary information about the effects of inhibiting miR-92a in central nervous system autoimmune disease.


Vitamin D With or Without Omega 3 Fatty Acids Reduces Risk of Autoimmune Disease

Brown bottle of vitamin D and fish oil capsules spilling onto wooden surface

In the first randomized, controlled trial to investigate whether supplementation with vitamin D and/or fatty acids can reduce the risk of autoimmune disease, Brigham researchers report that fatty acids alone did not reduce risk, but vitamin D or a combination of vitamin D and fatty acids was protective.


Making Headway in Targeting Glioblastoma Multiforme

Brain MRI showing a needle inserted into a glioblastoma multiforme tumor highlighted in purple

Break Through Cancer is a foundation that brings together elite cancer research centers to collaborate on and accelerate research, clinical trials and cures for deadly cancers, including glioblastoma multiforme. The Brigham’s Nathalie Y. R. Agar, PhD, and E. Antonio Chiocca, MD, PhD, discuss this ambitious undertaking.