Latest Clinical & Research News
Specialty: Rheumatology
Alisa Mueller, MD, PhD, Takanori Sasaki, MD, PhD, Deepak Rao, MD, PhD, and colleagues have demonstrated that for patients with unusual autoimmune or inflammatory conditions, cellular and transcriptomic immunophenotyping can serve as complementary diagnostic tools and guide treatment decisions.
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Jeffrey Sparks, MD, MMSc, and colleagues recently completed the first study of risk factors for repeat COVID-19 in an immunocompromised population. They report that use of rituximab, use of methotrexate, and younger age increased the risk of repeat COVID-19 among patients with systemic autoimmune rheumatic diseases.
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Researchers at Brigham and Women’s Hospital used information from two large U.S. cohorts to derive and validate a risk score that predicts clinically meaningful midlife declines in physical health and function among women. Importantly, the score is based on variables that are easy to obtain in clinical practice.
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Leaders from the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital presented over 120 abstracts and received several awards at the American College of Rheumatology’s 2023 annual Convergence conference. Read about a select portion of their research shared at the meeting.
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Sara K. Tedeschi, MD, MPH, played a key role in developing the recently released American College of Rheumatology and European Alliance of Associations for Rheumatology classification criteria for symptomatic calcium pyrophosphate deposition disease. She discusses the collaboration that went into the work and more.
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New research from the Brigham is providing novel insights into rheumatoid arthritis pathology and helping to advance targeted drug development and predict treatment response. Michael Brenner, MD, and Soumya Raychaudhuri, MD, PhD, discuss the efforts of a consortium of members from academic medical centers worldwide.
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Axial spondyloarthritis (axSpA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD). Anti-TNF agents are often used to treat concomitant axSpA and IBD. Brigham researchers have presented evidence that TNF inhibitors are less effective for axSpA than for IBD within one year.
Read More...Brigham scientists developed a method to simultaneously detect more than 2,000 CD1 lipid molecules that are displayed to T cells in the human immune system. This resulted in the first integrated CD1 lipidomic map, guiding the investigation of lipid T cell antigens and cleft blockers in any cellular system or disease.
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Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.
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Brigham orthopedist Christian Lattermann, MD, was the principal investigator of a study examining a possible connection between dysregulated inflammatory response and effusion synovitis after an ACL injury. He says risk stratification may help clinicians determine the appropriate treatment approach for each patient.
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