Traumatic cerebrovascular injury (TCVI)—blunt or penetrating injury to the carotid arteries, vertebral arteries, venous structures or a combination—can be a serious sequela of traumatic brain injury. TCVI may be obscured by nearby neurological injury and go undetected for weeks or even years after the initial injury.

Joshua D. Bernstock, MD, PhD, G. Rees Cosgrove, MD, and colleagues described unsuccessful thalamotomy in a patient who displayed hyperostosis calvariae diffusa—expansion of the frontal endocranium in addition to the bones within the skull—as well as tricortical osseous anatomy.

Brigham and Women’s Hospital investigators helped lead a multicenter, randomized, double-blind, sham-controlled trial of unilateral MRgFUS thalamotomy performed with the Exablate 4000 system (InSightec).

Propranolol, the current standard of care for essential tremor (ET), has significant shortcomings in efficacy and safety. As medicinal chemist Kevin Hodgetts, PhD, explains, Brigham investigators are developing novel therapies for ET patients by applying innovative drug design concepts to validated disease targets.

The Brigham’s AVM Program aims to provide the best possible nonsurgical and surgical treatment options for people with brain arteriovenous malformations (AVMs). Director Nirav J. Patel, MD, discusses his team’s use of an innovative surgical technique to treat AVM and efforts to set up similar programs internationally.

Researchers at Brigham and Women’s Hospital are investigating therapeutic focused ultrasound to enhance antibody delivery to the brain when treating Alzheimer’s disease.