Latest Clinical & Research News
Brigham and Women’s Hospital’s Jeffrey N. Katz, MD, MS, of the Orthopaedic and Arthritis Center for Outcomes Research, Melvin C. Makhni, MD, of the Department of Orthopaedic Surgery, and colleagues review the current evidence about managing acquired, degenerative lumbar spinal stenosis (LSS).
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Researchers at Brigham and Women’s Hospital have designed a biologic agent, dubbed EnMSCBif, to bind to death receptor 5 (DR5) on the surface of glioblastoma cells and trigger extrinsic programmed cell death. They report on the high potential of EnMSCBif to be translated into clinical use.
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The Telemedicine Working Group of AO Spine, a global academic community, convened an expert panel to attempt to reach a consensus on practical aspects of telemedicine related to spine care. Melvin C. Makhni, MD, in the Department of Orthopaedic Surgery, served as senior author of the report.
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Working with scientists at MIT, Brigham and Women’s Hospital researchers have developed a much simpler alternative to GI manometers called quipu-inspired, liquid metal–enabled pressure transducers (QUILT).
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Migraine and related headache disorders activate peripheral sensory neurons in the trigeminal ganglion (TG). Researchers at Brigham and Women’s Hospital have now mapped the TG cell types in both humans and mice and the genes they express.
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In 2018, Pichamol Jirapinyo, MD, MPH, and Christopher C. Thompson, MD, developed a modified technique they call distal POSE—which involves placing plications primarily in the gastric body, sparing the fundus. They have published a one-year study, concluding distal POSE appears safe and effective for treating obesity.
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The only head-to-head trial that compared biologics for treating ulcerative colitis (UC) found superiority of vedolizumab to adalimumab for clinical remission. Now, a retrospective study shows that biologic-naïve adults with UC stay on vedolizumab longer than either of the two tumor necrosis factor-α (TNFα) inhibitors.
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Robert R. Edwards, PhD, and colleagues explored the impact of expectancies on outcomes at three time points after total knee arthroplasty. They report that presurgical expectancies about pain reduction and functional improvement significantly predicted those outcomes only at the one-year follow-up.
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Researchers at Brigham and Women’s Hospital recently published a nationwide U.S. study of patients who received more than 90 days of oral anticoagulation after hospitalization for VTE. They found dispensing of apixaban, versus warfarin, was associated with a modestly lower hospitalization rate for recurrent VTE.
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Leaders from the Brigham’s Department of Pediatric Newborn Medicine presented their latest research to thousands of attendees at the 2022 Pediatric Academic Societies’ meeting. The department had a strong presence at this event, which took place April 21 – 25, 2022, in Denver, CO.
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