Genetic Mutation in Black Americans Boosts Risk of Transthyretin Amyloidosis
The V142I variant of the TTR gene, common among Black Americans, increases risks of cardiac amyloidosis, heart failure, and early mortality.
Read More... Study Finds 90% of Adults Have Stage 1 or Higher CKM Syndrome
A Brigham and Women’s Hospital research team established baseline epidemiological information about a new paradigm called cardiovascular, kidney, and metabolic (CKM) syndrome.
Read More...Novel Polygenic Risk Score Validated for Aortic Stenosis
Researchers at Brigham and Women’s Hospital developed a novel aortic stenosis polygenic risk score (PRS) that incorporates more than five million genetic variants. They verified it was associated with aortic stenosis in two independent, very large populations.
Read More...Mock Code Program Goes Beyond CPR to Test Brigham’s Emergency Response Systems
The Brigham and Women’s Hospital mock code program plans and conducts high-fidelity in situ simulations that not only allow participants to practice critical resuscitations but also test hospital systems for emergency response. Paul Jansson, MD, MS, and Andrew Eyre, MD, MS, elaborate on what distinguishes the program.
Read More...Nasal Tuft Cells Direct the Olfactory Mucosal Response to Allergens
Researchers at Brigham and Women’s Hospital report that TRPM5+ MVCs in the olfactory neuroepithelium not only are tuft cells but also have a role beyond triggering inflammation: they regulate olfactory stem cell proliferation.
Read More...Certain Blood Markers Linked to Premature Coronary Events in U.S. Women
By reviewing data from a long-term prospective study of U.S. women, researchers at Brigham and Women’s Hospital identified 12 biomarkers associated with premature CHD. They discuss the potential implications of biomarker screening and therapeutic strategies.
Read More...Commentary: Equitable Abortion Care for Patients With Non-English Language Preference
In this commentary, Brigham and Women’s Hospital physicians draw on their knowledge of drivers of language-related inequities to suggest best clinical practices for patients with language barriers who need abortion care. They propose ways to advance abortion equity at the clinician, health system, and societal levels.
Read More...GLP-1RA Use Linked to Reduced COPD Exacerbation Rates Compared With Other Diabetes Therapies
Brigham and Women’s Hospital researchers report that patients with type 2 diabetes and chronic obstructive pulmonary disease (COPD) who initiate GLP-1RA have a decreased risk of both moderate and severe COPD exacerbations compared to users of sulfonylureas or dipeptidyl peptidase 4 inhibitors.
Read More...Extracorporeal Cardiopulmonary Resuscitation Protocol on Preventing Sudden Cardiac Arrest Deaths
Conventional CPR, which combines rescue breathing with chest compressions, has been the primary treatment for cardiac arrest for nearly 60 years. Survival, however, remains frustratingly low. Brigham and Women’s Hospital is part of a collaborative effort to explore a promising new alternative: extracorporeal…
Read More...Brigham OB/GYN Ranks #1 in the Nation for Third Consecutive Year
Department Chair Nawal Nour, MD, MPH, MBA, reflects on U.S. News & World Report 2024-25 ranking Brigham and Women’s Hospital #1 in the nation for Obstetrics and Gynecology. She celebrates how the Department’s commitment to collaboration and transparency helps provide high quality, equitable OB/GYN care to patients.
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