Digestive Disease Week 2022

Woman presenting slides at a conference

Brigham and Women’s Hospital is honored to be participating in this year’s Digestive Disease Week (DDW) annual meeting.

This prestigious event offers digestive health experts from across the globe an opportunity to network and expand their knowledge in gastroenterology, hepatology, endoscopy and gastrointestinal surgery. DDW 2022 takes place May 21 – 24 in San Diego, CA, and is also being held virtually.

Dozens of gastrointestinal and endoscopic experts from the Brigham will present groundbreaking research and innovative lectures at the event. 100 research abstracts from the Division of Gastroenterology, Hepatology and Endoscopy have been accepted, including 37 lecture presentations and 63 posters—eight of which will receive a Poster of Distinction award. The Brigham will also present 17 invited lectures on a variety of topics, including interventional endoscopy, hepatology, fecal transplantation, medical informatics, and more.

Highlighted presentations are noted below. Please see the full schedule of Brigham presenters here.

Saturday, May 21, 2022

Assessment of a Multidisciplinary Weight Management Center at a Tertiary Academic Medical Center

Presenters: Thomas R. McCarty, MD; Christopher C. Thompson, MD

At 11:18 am, Dr. McCarty will be presenting the results of our study demonstrating an increase in clinic and procedure volume following complete integration of our multidisciplinary team at the Center for Weight Management and Wellness.

Endoscopic Gastric Plication Reduces Portosystemic Pressure Gradients in Patients With Nonalcoholic Steatohepatitis and Advanced Fibrosis

Presenter: Pichamol Jirapinyo, MD, MPH

At 4:00 pm, Dr. Jirapinyo will be presenting the results of a novel study combining bariatric endoscopy with endo-hepatology demonstrating an improvement in portosystemic pressure gradients (PPG) following endoscopic therapy in patients with advanced hepatic fibrosis.

EUS Guided Portosystemic Pressure Gradient (PPG) Measurements Are Safe and Feasible to Perform in Patients With FONTAN-associated Liver Disease

Presenters: Thomas J. Wang, MD; Marvin Ryou, MD

At 5:00 pm, Dr. Wang reports on the use of a novel EUS-based method of measuring portal pressure gradients in patients with Fontan-associated liver disease. This technology may help to elucidate liver disease in these patients with unique cardiopulmonary physiology.

A Multicenter Randomized Sham-controlled Trial of a Duodenal Jejunal Bypass Liner for the Treatment of Type 2 Diabetes Mellitus

Presenter: Christopher C. Thompson, MD

At 4:00 pm, Professor Thompson will be presenting the results of a multicenter randomized trial demonstrating that the duodenal jejunal bypass liner met glycemic control and weight loss endpoints while showing meaningful improvements in comorbidities.

Mechanisms of Action of Intestinal Procedures

Presenter: Pichamol Jirapinyo, MD, MPH

At 2:35 pm, Dr. Jirapinyo will be summarizing mechanisms of action of small bowel endoscopic bariatric and metabolic therapies (EBMTs) including foregut and hindgut mechanisms and their effect on the neurohormonal enteric axis.

Full Spectrum vs. Defined Consortia. Does it Matter?

Presenter: Jessica R. Allegretti, MD, MPH

At 5:06 pm, Dr. Allegretti will review whole spectrum versus defined consortia microbiome therapeutics during the Frances and Don W. Powerll, MD Lecture on New Views in C. difficile Infection.

State-of-the-Art Presentation: The Making of a Bariatric Endoscopist

Presenter: Christopher C. Thompson, MD

At 4:20 pm, Professor Thompson will be giving a state-of-the-art lecture on the technical and cognitive aspects of training in bariatric endoscopy and the importance of a multidisciplinary weight center.

NASH: Mechanistic Insights from Bench to Population Based Studies: Genes and the Environment

Presenter: David E. Cohen, MD, PhD

At 4:00 pm, Dr. Cohen will provide an overview on the current understanding of the mechanism of non-alcoholic steatohepatitis (NASH), with insights from bench to bedside to population-based research.

Acid Suppression Therapy Is Independently Associated With Reduced Risk of 1-Year Mortality Following Lung Transplantation

Presenter: Wai-Kit Lo, MD, MPH

At 12:30 pm, Dr. Lo will present this Poster of Distinction. While gastroesophageal reflux disease has been linked to lung transplant rejection, the role of medical antireflux therapy has been unclear. Dr. Lo will discuss the results from a large cohort of over 450 lung transplant recipients at BWH that demonstrates the potential benefits of acid suppression therapy in reducing mortality post-transplant.

Sunday, May 22, 2022

The Effect of Endoscopic Gastric Plication on Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis

Presenter: Pichamol Jirapinyo, MD, MPH

At 3:10 pm, Dr. Jirapinyo will be presenting the results from the first study that demonstrates an improvement and reversal in hepatic fibrosis following endoscopic sleeve gastroplasty in patients with NAFLD/NASH and advanced fibrosis.

Feasibility of Hospital-Level Care at Home for Non-Severe Acute Pancreatitis

Presenter: David X. Jin, MD, MPH

At 2:24 pm, Dr. Jin will be discussing the feasibility and the BWH experience in providing hospital-level care at home through the “Home Hospital” program for non-severe acute pancreatitis.

Endoscopic Management of Subepithelial Lesion

Presenter: Linda S. Lee, MD

At 10:43 am, Dr. Lee will provide an overview and share insights in the endoscopic management of subepithelial lesions.

Monday, May 23, 2022

Endoscopic Ultrasound-Guided Coil Injection Therapy in the Management of Gastric Varices: The First U.S. Multicenter Experience

Presenters: Ahmad Bazarbashi, MD; Marvin Ryou, MD

At 9:00 am, Dr Bazarbashi reports on the first US multicenter experience of EUS guided coil injection for the treatment of gastric varices. The technique is shown to be safe with excellent hemostatic efficacy.

Endoscopy in the COVID-19 Era: Impact on Disparities in Ambulatory Endoscopic Care

Presenters: Nicolette J. Rodriguez, MD (AGA Fellow Abstract Prize); Walter W. Chan, MD, MPH

At 11:00 am, Dr. Rodriguez will discuss the impact of the COVID-19 pandemic on ambulatory endoscopic care delivery and how it may widen existing disparities in care to racial/ethnic minorities and underserved populations.

One- and Two-Year Outcomes After Ustekinumab Dose Intensification for Inflammatory Bowel Disease

Presenters: Rahul Dalal, MD; Jessica R. Allegretti, MD, MPH

At 12:30 pm, Dr. Dalal will present the one- and two- year outcome of a cohort of 163 patients with IBD (123 Crohn’s disease, 40 ulcerative colitis) who had dose intensification of ustekinumab. The study demonstrated >50% and >40% of patients were in steroid-free clinical remission after 12 and 24 months, respectively.

Tuesday, May 24, 2022

Anorectal Manometry Findings per London Classification Independently Predicted Patient-Reported Clinical Outcomes Using GI-PROMIS Symptom Scales

Presenters: Catherine Wang, MD; Walter W. Chan, MD, MPH

At 11:15 am, Dr. Wang will present the results of a large cohort of patients undergoing high-resolution anorectal manometry and how the findings as defined by the expert-consensus London Classification predicted patient-reported clinical outcomes.

Comparative Assessment of Esophageal Proteomics in Eosinophilic Esophagitis Using Somascan

Presenter: Walter W. Chan, MD, MPH

At 10:30 am, Dr. Chan will discuss findings from a proteomic study of patients with eosinophilic esophagitis (EoE) using Somascan on prospectively collected esophageal mucosal biopsy specimens, comparing patients with PPI-responsive and those with PPI-non-responsive disease. Identifying unique protein candidates for PPI-responsive EoE may allow future development of testing target to direct therapy and potentially identify new therapeutic targets for EoE.

Gastroplasty With Endoscopic Myotomy (GEM) for the Treatment of Obesity

Presenter: Christopher C. Thompson, MD

At 11:56 am, Professor Thompson will be presenting the first report of a novel physiology-based endoscopic bariatric procedure employing a pylorus-sparing antral myotomy in combination with endoscopic sleeve gastroplasty to further delay gastric emptying and promote weight loss.

Magical Thinking: What Patients and Physicians Want Versus the Black Box

Presenter: Lin Shen, MD

The promise of AI in medicine faces real world challenges in implementation. At 10:25 am, Dr. Shen explores practical considerations and looks under the hood at the innerworkings of using AI in the clinical setting.

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